Joined August 2018
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2 is better than 1 – Our recent work in #mBio identifies a FoxJ as a 2nd σE-dependent #sRNA in #Fusobacterium. Not only does FoxJ act as negative regulator but also positively regulates some mRNA targets - offering a new trick for σE-dependent sRNAs. tinyurl.com/427rpkpj
Falk Ponath retweeted
Small RNA w/big roles in colonization
@MoualiYoussef @StrowigLab characterize RNA landscape of Segatella copri. ID small RNA regulator essential for colonization & whose expression is regulated by metabolism of dietary components by S. copri
cell.com/cell-host-microbe/f…
Check out the spectacular work led by @MoualiYoussef - giving insights into #sRNA regulation in the unexplored #Segatella/#Prevotella impacting metabolism and interactions with the host & commensals in the gut🦠
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Falk Ponath retweeted
New research from @BullmanLab /@CJohnstonLab1, with superstar 1st author @mzepedar, out now in
@Nature pinpoints “high-risk” subtype of Fusobacterium nucleatum that dominates the colorectal
cancer (CRC) niche in human patient's
Link : rdcu.be/dBUjH
Tweet🧵below:
Falk Ponath retweeted
A new study from Bullman and @CJohnstonLab1 @fredhutch out today @Nature. We identify a 'high-risk' clade of F. nucleatum that dominates the human CRC niche. Huge congrats to the amazing first author @mzepedar and the incredible team.
🧵 from Chris 👇
nature.com/articles/s41586-0…
New research from @BullmanLab /@CJohnstonLab1, with superstar 1st author @mzepedar, out now in
@Nature pinpoints “high-risk” subtype of Fusobacterium nucleatum that dominates the colorectal
cancer (CRC) niche in human patient's
Link : rdcu.be/dBUjH
Tweet🧵below:
Falk Ponath retweeted
1/5: Molecular intricacies of gut bacteria! 🧬 Our study in @NatureMicrobiol , with colleagues from @Helmholtz_HIRI, @DeutschbauerLab , & @LBarquist groups, unveils B. thetaiotaomicron's transcriptional landscape across 15 gut conditions. nature.com/articles/s41564-0…
Falk Ponath retweeted
Very excited to finally see our study of global RNA stability in Salmonella out today in
@PNASnews, where we use Bayesian statistical modeling to show bacterial transcripts have subminute half-lives, far shorter than previously thought. pnas.org/doi/10.1073/pnas.23… 1/n
Falk Ponath retweeted
Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Random forest trained with #organoid #colibactin mutations => identification of pks-linked mutations in every 8th #colorectal tumor genome! authors.elsevier.com/sd/arti….
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Also, a big shout-out to @SciGraphix for the amazing work on these beautiful figures.
And for additional information see our previous work identifying the sigma E regulon and the first sRNA FoxI alongside some genetic tools for #Fusobacterium : pnas.org/doi/abs/10.1073/pna…
Falk Ponath retweeted
Happy to share our latest work, spearheaded by @prezzag in collaboration with @BeiselLab @Helmholtz_HIRI and just out @PNASNews.
We set up a CRISPRi system in B. thetaiotaomicron and used it to screen sRNAs for their functions. [1/5]
pnas.org/doi/10.1073/pnas.23…
#Fusobacterium harboring KH-domain containing #RBP - have a look at this great work led by @yanzhu0329 putting great effort into establishing a broadly applicable pulldown method for RBP identification using #sRNAs & uncovering an ethanolamine-dependent phenotype for KhpB/A
So excited to share that our preprint discovering KhpA/KhpB as broad RBPs in fusobacteria are now out in @NAR_Open. Big thanks to my supervisor @JoergLab and @AnkeSparmann, TeamFuso @PonathF , as well as all supports from Vogel Lab @Helmholtz_HIRI!
academic.oup.com/nar/advance…
Falk Ponath retweeted
Proud to present SHIFTR, a novel platform for region-specific RNA interactome discovery developed by fantastic PhD student @jensaydin 👨🔬 in my group, now published in @NAR_Open:
1/8
academic.oup.com/nar/advance…
Falk Ponath retweeted
A new preprint of my PhD project @JoergLab working with TeamFuso @PonathF and Valentina Cosi, identifying two KH domain proteins-KhpA and KhpB as broad RBPs in Fusobacterium nucleatum.
A global survey of small RNA interactors identifies KhpA and KhpB as major RNA-binding proteins in Fusobacterium nucleatum biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Falk Ponath retweeted
Happy to share our latest work: Fusobacterium are naturally competent through Type IV pili. Great, concise study led by @blake_e_sanders and others not on twitter. We discovered it, now you go figure out what to do with it. sciencedirect.com/science/ar…
Falk Ponath retweeted
A conveyor belt of DCs: FLT3L regulates the spatiotemporal cascade of DC-development in LNs. Fascinating work from @Kamulab @ugur_milas out @ImmunityCP, great teamwork @Wue_SI @dominic_grun @AE_Saliba - open access cell.com/immunity/fulltext/S…
Falk Ponath retweeted
I ventured into the new world of RNA at @JoergLab with great support from @HoebartnerLab @LBarquist @jakobjung & the other co-authors!
Preprint:
A side-by-side comparison of peptide-delivered antisense antibiotics employing different nucleotide mimics biorxiv.org/content/10.1101/…
Falk Ponath retweeted
First paper from the Adams lab @NICHD_NIH is out @NatureComms!
We comprehensively mapped RNA and characterized transcription termination in the Lyme pathogen B. burgdorferi —
hundreds of truncated transcripts and potential regulators!
nature.com/articles/s41467-0… – at Bethesda, MD
Falk Ponath retweeted
Our latest work, from @prezzag and in collaboration with @BeiselLab: we constructed a CRISPRi library of the intergenic sRNAs of B. theta and used it to identify modulators of growth under bile. Presenting BatR, the third sRNA we have characterized so far! biorxiv.org/content/10.1101/…
