➡️ https://xitter.cf/t.co/0x051fans3 🦋 https://xitter.cf/t.co/3HwHCi2MKF 🦋 comp. biologist, species-specific antibiotics. (he/him)
Joined January 2013
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Happy to share my 1st 1st-author publication!
Our experiments reveal mismatch-position dependency of antisense-PNA #antibiotics. We Included this in MASON, a web-based PNA design tool. Big thanks for the support of the co-authors/helpers from @LBarquist @JoergLab @Helmholtz_HIRI
The MASON webserver offers improved design of RNA-targeting antisense antibiotics, taking account of position-dependent effects of mismatches on target bacteria bit.ly/40P05dx
ALT The MASON webserver offers improved design of RNA-targeting antisense antibiotics, taking account of position-dependent effects of mismatches on target bacteria
Jakob Jung retweeted
#WorldHealthDay highlights the urgent need for new antibiotics. From microbes to mammoths, scientists are uncovering antimicrobial compounds in unexpected places, including ancient DNA.
Read how past & present biology shapes infection treatment: buff.ly/PZoYtvy
Jakob Jung retweeted
How do airway cells react to microbes 🫁🦠🧬?
van Woudenbergh et al. show how nasal, nasopharyngeal & bronchial epithelia mount distinct immune responses to viruses and bacteria—helping explain disease outcomes #PathogDis
Read the full paper here👉 buff.ly/1czVtK8
Jakob Jung retweeted
Turning E. coli into a comic-book hero or villain🦸♀️🦹♂️🦠
Gozzi et al. show how the Adopt-a-Bacterium method lets biomed students craft memes, games & comics to teach microbiology—boosting engagement, teamwork and #SciComm. #FEMSMicrobiolLett
buff.ly/Iw6TncN
Jakob Jung retweeted
Wir stellen unsere Aktivitäten auf X ein. 👋
Updates zu unserer Forschung und der Welt der Infektionsforschung findet ihr weiterhin hier:
LinkedIn: linkedin.com/company/helmhol…
Bluesky: bsky.app/profile/helmholtzhz…
Mastodon: helmholtz.social/@Helmholtz_…
Instagram: instagram.com/helmholtz_hzi/
Jakob Jung retweeted
Die Rede von Kevin Kühnert müssen alle Menschen hören.
Eine Rede mit historischer Bedeutung.
Jakob Jung retweeted
Now, more than ever, we must embrace #diversity, #equity, and #inclusion in education.
A #FEMSMicrobiolLett article explores approaches that empower learners, foster belonging, and spark lifelong learning. #InclusiveEducation #DEI
academic.oup.com/femsle/arti…
Jakob Jung retweeted
Der #Wahlomat ist da. Die Bundestagswahl steht vor der Tür und gerade mit den Ereignissen der letzten Woche hat mich die Übereinstimmungen der Parteien interessiert. Daher habe ich das mal ausgewertet.
Jakob Jung retweeted
Interested in multiplexing samples for nanopore dRNA sequencing with the new chemistry? Check out our newly released RNA4 model!
4 barcode model available here:
github.com/KleistLab/WarpDem…
1/6 🎉 Excited to announce WarpDemuX v0.4.4 with RNA004 support! Our (@PatrickBohnPB ) WDX4 model achieves 99.5% target accuracy with 95% yield on the latest RNA sequencing kit from @nanopore. Release notes at: github.com/KleistLab/WarpDem…
Jakob Jung retweeted
Emergency bulletin! 14 journals have co-published an urgent call for the deployment of microbial solutions against climate catastrophe, by @peixotors et al.
nature.com/articles/s41564-0…
Jakob Jung retweeted
We used in-vitro laboratory evolution to "stress test" the next generation class of antibiotics based on antisense oligos ("asobiotics"). Head over to our new preprint to find out more!
(links in the next tweets)
ALT Panel A from figure 1 of the preprint showing the strains and asobiotics used, as well as the in-vitro laboratory evolution assay
Jakob Jung retweeted
I am excited to finally share this preprint from @JoergLab.
We've developed a reporter assay to enable high throughput discovery of carriers for ASOs into bacteria.
This was a challenging and exciting journey for me, from MedChem/ChemBio into Mol/SynBio.
RNA toehold switch-based reporter assay to assess bacterial uptake of antisense oligomers biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Jakob Jung retweeted
How do you distill #microbiome complexity into ecologically meaningful units?
Clear away the confusion with MICROBIOME FOR DUMMIES: journals.asm.org/doi/10.1128…
Jakob Jung retweeted
This is big!
Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
Fresh out in @TheLancet including age- and geo-resolved data and predictions.
thelancet.com/journals/lance…
Jakob Jung retweeted
Happy #InternationalMicroorganismDay to everyone celebrating across the world! 🌐
It's only with such a devoted community that this day has become such a special celebration.😁
Cheers to the #microbes! 🦠
internationalmicroorganismda…
Jakob Jung retweeted
Shall we start calling them „asobiotics“? Probably easier than „antisense-based antibiotics“ or „antibacterial peptide-delivered antisense drugs“, to name just a few of the current names. To be discussed. Anyway, ASOBIOTICS 2024 was a big success. Big thanks to everyone involved.
Jakob Jung retweeted
🚨 New paper alert! 🚨 Check out the latest publication from @LBarquist's lab in @mbiojournal! Huge congratulations to all authors on this exciting work. Learn more in the thread below! 🧵⬇️
We determined gene essentiality in 13 Enterobacteriaceae including E. coli, Salmonella and Klebsiella strains, and find ~1/3 of the essential genome is variable -- but! there's no evidence for genus-specific essential genes, implying rapid turnover journals.asm.org/doi/10.1128…
Jakob Jung retweeted
High-throughput transposon mutagenesis in the family Enterobacteriaceae reveals core essential genes and rapid turnover of essentiality
@mbiojournal from @LBarquist
journals.asm.org/doi/10.1128…
Jakob Jung retweeted
We determined gene essentiality in 13 Enterobacteriaceae including E. coli, Salmonella and Klebsiella strains, and find ~1/3 of the essential genome is variable -- but! there's no evidence for genus-specific essential genes, implying rapid turnover journals.asm.org/doi/10.1128…
Jakob Jung retweeted
The big consultants haven't just benefited from a weakened state - they've championed an ideology of short-termism and risk aversion in the public sector. Ending this 'consultancy cult' is crucial for transforming our economy.
Full article by me and @RosieCollingto for @NewStatesman ⬇️ newstatesman.com/comment/202…
Jakob Jung retweeted
ASO technology using exogenous delivery of antisense oligonucleotides offers many diverse applications, from killing pathogens to reprogramming genetically intractable microbes. Time to organize the first conference on ASOs & microbes! Register at helmholtz-hiri.de
