@PostEra_AI

Medicinal Chemistry powered by Machine Learning

postera.ai
Joined March 2020
  • Tweets324
  • Following3
  • Followers1.3K
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'It began with a tweet.' Alpha Lee of @PostEra_AI reflects on the Covid Moonshot experiment – an open science effort to develop an antiviral drug – nearly 4 years on. chemistryworld.com/opinion/s…

Spearheading antiviral discovery with AI and open innovation

The Covid Moonshot experiment

chemistryworld.com
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The COVID Moonshot project has just been published in @ScienceMagazine! Take a read of our journey to develop patent free COVID antivirals. 🧵... Read the full article ➡️ science.org/doi/full/10.1126… #AI #OpenScience #Covid
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Moonshot has been a true global partnership since the start with over 400 scientists involved, and we're thankful to @SCIupdate for recognizing these efforts! @DNDi @PostEra_AI @UniofOxford @MedChemica @jchodera @EnamineLtd @DiamondLightSou
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📢 Moonshot preclinical update! We selected a fine chemicals provider to supply the key synthetic intermediate required to complete the final synthetic steps in the scale-up of our advanced lead, DNDI-6510, for Phase I studies... @DNDi @PostEra_AI @DiamondLightSou @jchodera
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👀🔥 New piece! "What to Watch in AI" highlights 10 promising companies transforming industries with AI. Jump into the full piece or keep scrolling for the tweet-sized summaries of each. thegeneralist.substack.com/p…
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Enjoying seeing so many great colleagues at #DiscoverBMB & chairing a session on AI & computation in drug discovery & design feat. @UWproteindesign @PostEra_AI @wpwalters 🤩🤓
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Replying to @matteo_aldeghi
Very sorry to hear! We've open positions in ML for chemistry and drug discovery @PostEra_AI. Feel free to dm.
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One week until the @bitsinbio teach-and-greet high above the Charles and streaming 🌎🌍🌏, featuring Ganymede, @Dyno_Tx, @PostEra_AI, and @manifoldbio, who get a raincheck if still celebrating last week’s $40M Series A! Register ASAP to attend or stream: eventbrite.com/e/38242964636…

Bits-In-Bio Lighting Talks (Brass Tacks of Running a SW Biz in Bio)

How do software- and ML-focused biotechs *actually work*? Join us (live in Boston, or via Zoom worldwide) for four chalk talks & discussion.

eventbrite.com
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Lots of buzz about SW and ML-focused biotechs; much less about how they work (what's *really* built; how that's differentiating). On 7/24, @bitsinbio @MorseCell & I go brass tacks w/ Ganymede @Dyno_Tx @manifoldbio @PostEra_AI. Attend in person, or stream: eventbrite.com/e/38242964636…
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If you haven't checked Manifold by @PostEra_AI Do it right away! #AI #drugdiscovery
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Our goal at @asap_discovery is to harness advances in AI/ML and computational chemistry technologies to accelerate the discovery of oral antivirals for current and future pandemics, with a focus on global, equitable, and affordable access to therapeutics: dndi.org/press-releases/2022…
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NIH awarded $68M to "ASAP" consortium co-led by Boston-based AI for drug discovery/medicinal chemistry startup @PostEra_AI, nonprofit @DNDi & @MSKCancerCenter w/goals 2 "discover dozens of lead compounds against key viruses of significant pandemic concern" prnewswire.com/news-releases…

PostEra spearheads AI-driven drug discovery collaboration to develop antiviral therapeutics with...

/PRNewswire/ -- PostEra, a biotechnology company specializing in machine learning for preclinical drug discovery, today announced a multi-year collaboration...

prnewswire.com
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The goal of small molecule drug discovery is to accelerate research of life saving drugs 🚀 This is what @PostEra_AI (the company where I work) is doing, using ML. Here is a short overview of the field: nature.com/articles/d43747-0…

Artificial intelligence makes a splash in small-molecule drug discovery

Biopharma Dealmakers - Companies applying artificial intelligence tools in small-molecule drug discovery have recently attracted substantial financing and a multitude of large pharma partners.

nature.com
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Thanks @endpts for reporting! Excited to help advance antiviral discovery with AI, working with friends @covid_moonshot and @asap_discovery! endpts.com/nih-grants-over-5…

NIH grants over $500M to create antivirals for future pandemics

As the US transitions away from Covid-19 vaccine science into more therapeutic work, the NIH has awarded $577 million to nine groups in an effort to drive antiviral development for ...

endpoints.news
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First flight in two years. Was great meeting in person *for the first time* some of my @covid_moonshot co-conspirators!
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Founder Spotlight 🔬: Aaron Morris @ PostEra Learn more about Aaron Morris & @PostEra_AI below... ow.ly/8rjY50Ij5gP
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Today I started a new job at @PostEra_AI, a company looking to accelerate drug discovery with ML! ⚗️ Computation is going to revolutionize bio. ✨
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An important interview with @griffen_ed just out in @medicine_maker on how key Moonshot partners like @EnamineLtd are being affected by the war in Ukraine and its broader impact on our industry. @AngusLikesWords themedicinemaker.com/discove…
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COVID Moonshot has shown our open science, structure-enabled AI-driven approach can go from fragment screen to preclinical phase in 18 months spending less than $1M. We think our model is capable of changing antiviral discovery for pandemics for good...
Timeline showing the COVID Moonshot’s progression from fragment screen in Mar 2020 to funding for the preclinical phase in July 2021

ALT Timeline showing the COVID Moonshot’s progression from fragment screen in Mar 2020 to funding for the preclinical phase in July 2021

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Today we're delighted to share a significant milestone in Moonshot’s journey towards an open-science COVID antiviral: We have identified compounds meeting our criteria for progression to preclinical evaluation!
Chemical structure of a key antiviral compound from the COVID Moonshot, showing excellent antiviral activity and enzymatic potency

ALT Chemical structure of a key antiviral compound from the COVID Moonshot, showing excellent antiviral activity and enzymatic potency

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