Mom, Scientist. Vaccine/infection immunology, Forever fascinated by antibodies. views are my own.
Stockholm, Sweden
Joined October 2012
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Check out our paper showing how IGHV1-69 polymorphisms can affect SARS-CoV-2 antibody functions. Amazing supervision from @NillaKH Martin Corcoran.
Great collaboration with @BenjMurrell @DannySheward @das_hrishikesh1 @BMartinHallberg out @ImmunityCP
cell.com/immunity/fulltext/S…
Antibodies with shared structure and CDR H3 sequence features from 3 recent publications take center stage in our Trends in Microbiology Spotlight.
A classic example of how mAbs help guide vaccine design.
sciencedirect.com/science/ar…
Pradeepa Pushparaj retweeted
It's an absolute scandal and tragedy that India is forced to spend $250m/year to provide access to the latest science to its people. A complete and total failure of global science leadership and of science writ large.
By reintroducing somatic hypermutations into a germline-reverted mAb, we delineate the role of affinity maturation in the development of cross-neutralization in a public class of antibodies.
As always, antibodies are fascinating.
Thanks to @NillaKH and everyone involved 🤍
Finally out! Structural insights into antibody affinity-maturation. Thanks to @DannySheward @Pradee05 @das_hrishikesh1 @BenjMurrell @mcinerney_gerry
@Jan_Albert_ @_LeoHanke @AllieGreaney @jbloom_lab @NillaKH cell.com/cell-reports-medici…
Pradeepa Pushparaj retweeted
Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem dlvr.it/Sz4Cs3
Very well deserved! :)
BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Pradeepa Pushparaj retweeted
Real-time data update: we've got our first BA.2.86 (see red arrow) neutralization results. Short 🧵with much credit to @DannySheward and the rest of the team.
Pradeepa Pushparaj retweeted
Sharing some new experimental data on BA.2.86:
1) BA.2.86 is antigenically distinct compared to XBB.1.5.
2) BA.2.86 can significantly escape XBB-infection/vaccination induced antibodies.
3) However, the infectivity of BA.2.86 may be much lower than XBB.1.5 and EG.5. (1/n)
Pradeepa Pushparaj retweeted
Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites biorxiv.org/cgi/content/shor… #biorxiv_immuno
Pradeepa Pushparaj retweeted
Our paper now out in @ImmunityCP authors.elsevier.com/sd/arti… doubles the number of known expressed TCR alleles, providing new possibilities in T cell immunology research. Thank you @Vetenskapsradet, @ERC_Research and @karolinskainst for supporting our team.
“Understanding antibody germline gene variation is important as it can help explain why we differ in our abilities to control infections or respond to vaccination”
full interview here
news.ki.se/new-publication-o…
Pradeepa Pushparaj retweeted
I wanted to summarize what is known about the new XBB.1.5 variant of SARS-CoV-2, which is starting to generate a lot of interest.
(There are no new scientific results in this thread, it simply aggregates previously reported results for those not following topic closely.)
Pradeepa Pushparaj retweeted
"When I first came here, I'm a bit ashamed to admit this, but I was trying to hide the fact that I came from Lebanon."
2021 medicine laureate Ardem Patapoutian on the importance of inclusion and learning to love his immigrant background.
#NobelPrize
Pradeepa Pushparaj retweeted
Outstanding work by talented doctoral student @Pradee05 with great support from Andrea Nicoletto and several others in the group + dedicated collaborators. IgDiscover helps us understand why we respond differently to infections.
Check out our paper showing how IGHV1-69 polymorphisms can affect SARS-CoV-2 antibody functions. Amazing supervision from @NillaKH Martin Corcoran.
Great collaboration with @BenjMurrell @DannySheward @das_hrishikesh1 @BMartinHallberg out @ImmunityCP
cell.com/immunity/fulltext/S…
Pradeepa Pushparaj retweeted
”Med rådande migrationshantering går Sverige miste om kompetens inom forskning” - läs hela min debattartikel om hur migrationspolitiken och lagstiftningen drabbar forskarsamhället i @FoFramsteg fof.se/artikel/absurda-beslu…
We are a fun bunch of antibody geeks ♥️
Gunilla Karlsson Hedestam group at Karolinska Institute, Sweden 😊 @NillaKH
Ridiculous.
Hej @Migrationsverk,
Den här utländska forskaren har just disputerat på @karolinskainst och fått ett 3-årigt internationellt postdoc-anslag fr @Vetenskapsradet (VR), men i och med att VR kräver! att hon tillbringar delar av de 3 åren utomlands så utvisar ni henne? Hur tänker ni?
Pradeepa Pushparaj retweeted
A study by @benjmurrell et al shows that #SARSCoV2 #Omicron sublineage BA.2.75.2 largely evades neutralizing antibodies in the blood and is resistant to several monoclonal antibody antiviral treatments. Now published in @TheLancetInfDis.
news.ki.se/new-omicron-subva…
ALT Illustration by Getty Images.