🚨 New preprint! 🚨
Wnt/Ror2 signaling stabilizes basal identity. Using lineage tracing, we show that Ror2 loss disrupts mechanotransduction (RhoA-ROCK1-YAP1) & chromatin accessibility, driving a basal-to-luminal transition in the mammary gland.
🔗:biorxiv.org/content/10.1101/…
A new study reveals how mammary tissue limits oncogenic mutations through multiple layers of protection. Self-renewing cells create barriers to mutation spread, while local tissue remodeling and duct geometry help eliminate most mutant clones. A must-read!🔖
Super happy to share that our paper is published in @Nature today! We've discovered how the breast is protected against tumor initiation—though it comes at a cost. 📰Read all about it here: bit.ly/3MSxoa1 🏥@vib_ccb @Onco_KULeuven @NKI_nl @vanRheenen_Lab @BenSimons_Lab
Kevin Roarty retweeted
What do cancer patients actually die from? The precise causes of mortality and patient deterioration before death in patients with cancer remains poorly understood | → rdcu.be/dLgsZ ← | 🧵(1/5)
So excited to share that my graduate student Maddie won 1st place oral presentation at the @bcmhouston Breast Center's Breast Cancer Research Retreat. The competition was tough, with so many great talks from other trainees. So proud! #BCM #BreastCancerResearch #FirstPlace
Kevin Roarty retweeted
⏰ The MRS Advocate Researcher Program (MetARP) for the upcoming Meeting in London is open until April the 15th. The goal of MeTARP is to build relationships between researchers and advocates 🙏, and offers awardees a generous travel fund ✈️. Apply now! bit.ly/3TjR8pv
Kevin Roarty retweeted
The April issue of @CD_AACR is online and features a series of commentaries on how to move the field of cancer research forward. Enjoy!
aacrjournals.org/cancerdisco…
Kevin Roarty retweeted
I am pleased to share the final version of our Human Breast Cell Atlas with @MarioniLab now out @NatureGenet. There are important new additions, which I will leave to @Dr_SaraPensa and @AustinDReed to mention👇 . Couple of points i want to highlight 👇:
nature.com/articles/s41588-0…
I am very pleased to share our second and largest contribution to “The Human Breast Cell Atlas” (HBCA) project. Buckle up a longish thread ahead!
biorxiv.org/content/10.1101/…
Meet my wife, the real MVP 🌟. From mastering the secrets of the universe at Auburn to outsmarting cancer at MD Anderson Cancer Center, she proves that behind every great scientist is an even greater woman. Proud husband alert! #ScienceMeetsSuperhero #ProudHusband"
Kevin Roarty retweeted
Have you ever wondered what happens to mammary tissue when a mouse gets UTI? No? So check out the work of Sam Henry, @stevenmlewis7 @SamanthaCyrill!!!
Check out our work on how local infection can impact a distal tissue - with the amazing dos Santos team @SamanthaCyrill @mKate588 @DeeptimanChatt2 @caoresco @CicconeMichael @amritha92 biorxiv.org/content/10.1101/…
Kevin Roarty retweeted
Places are filing up for the 2024 Mammary Gland Biology GRC @GordonConf . We have an exciting line up of speakers 👇 and 12-14 spots for talks selected from abstracts. If you have an exciting new study submit your abstracts soon!
RT please.
grc.org/mammary-gland-biolog…
B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling: Cancer Cell cell.com/cancer-cell/fulltex…
Kevin Roarty retweeted
MD Anderson is hosting our annual Leading Edge of Cancer Research Symposium on Nov. 16-17, when researchers from around the world discuss emerging topics driving the next cancer breakthroughs.
Learn about this in-person symposium: bit.ly/3RVLVFs @DraettaG #EndCancer
Kevin Roarty retweeted
We are honored to post @HillStirSci @CancerResrch @bobriter @CancerCornell blog focused on a history of #breastcancer advocacy. #BCAM #CancerResearch theresasresearch.org/marp/20… – at The Woodlands, TX
🔬🌟Join us @BCMhouston! Seeking Faculty in the Dept. of Molecular & Cellular Biology at Baylor College of Medicine! #CancerResearch & #CellBiology! 📅 Apply by Nov 1! 🌐 nature.com/naturecareers/job… Experience vibrant Houston and great science within @TXMedCenter! #AcademicTwitter👇
Recruiting faculty to the Dept of Molecular and Cellular Biology at Baylor College of Medicine in Houston! Recruiting broadly in cancer and cell biology. Apply by Nov 1, 2023. @BCMhouston
nature.com/naturecareers/job…
bcm.edu/departments/molecula…
Kevin Roarty retweeted
Well written story featuring our @DanaFarber colleagues @TariKingMD and Leticia Varella @DFCI_BreastOnc
More young women are getting breast cancer. They want answers. washingtonpost.com/wellness/…
👏 A big shout-out to Hongjiang Si from our @RoartyLab at @bcmhouston for being honored with the @MBoCjournal Early Career Paper Award. His insightful work on Wnt/Ror2 signaling is making valuable contributions to breast cancer research. Keep up the excellent work, Hongjiang!
Hongjiang Si, @bcmhouston, has won a @MBoCjournal Early Career Paper Award for “Noncanonical Wnt/Ror2 signaling regulates cell–matrix adhesion to prompt directional tumor cell invasion in breast cancer.”
molbiolcell.org/doi/10.1091/…
Now out: Our review on the complexities of #BreastCancerMetastasis. The interplay of cells, molecules, & physical factors that drive metastasis is as fascinating as it is daunting. By understanding more, we hope to contribute to the discovery of future treatments.@FrontCellDevBio
Kevin Roarty retweeted
The Metastatic Breast Cancer Research Conference is now accepting abstracts from all areas of metastasis research. #MetastaticOdds
Deadline: June 7
Registration and abstract submission: na.eventscloud.com/ehome/mbc…
Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal cell.com/cell-stem-cell/full…



















