Deciphering cellular and molecular mechanisms of synaptic function and impact on neuronal circuit output. Viral vector development and CNS gene therapy.

Iowa City, IA
Joined December 2018
For ~25 years Ad vectors had little to no ability to transduce Purkinje cells, until now! Excited to announce our paper in MTMCD @MolTherapy on the development of Ad vectors that transduce Purkinje cells in a humanized mouse model shorturl.at/wyBW5
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Wondered why different synapses have distinct presynaptic Cav2 subtype composition? Read our paper @JPhysiol by grad student @jianing59966408 doi.org/10.1113/JP284957 We define the motifs in Cav2 α1 subunit that control subtype and preference @UIowaResearch @UIowaNeuro
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Cake to celebrate Uchechi and Madhuri being awarded Post Comp Fellowships from the UI Grad College Uchechi is developing gene therapy approaches to treat A-T Madhuri is deciphering the molecular mechanisms for ultrafast synaptic transmission in hearing @UIGradCollege @UIowaACB
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CONGRATULATIONS to Madhuri Bendale who passed her comps on Aug 9 and is an official PhD candidate in the UI CDB Keep an eye on this budding superstar Madhuri's PhD will be on Molecular Mechanisms of ultrafast auditory synaptic transmission @UIowaACB @UIowaNeuro @UIGradCollege
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CONGRATULATIONS to Uchechi Okoroafor, who passed her comps on Friday and is an official PhD candidate in the UI CDB program Keep on eye on this budding superstar Uchechi's PhD will be on Developing Novel Gene Therapy approaches to treat A-T @UIowaNeuro @UIowaACB @UIGradCollege
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Giant Synapse 2023 Nov 10/11 Georgetown University Synapses reign supreme Meeting is free will be multiple trainee talks too please RT @KateOCG @NChanaday @CAndrewFrank @SynapsesInSight @mossy_fibers @JasonSynaptic @JMC_Scientist @KLabGPCR @KT_Kindt @TedAbelneuro @BlackInNeuro
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Giant Synapse update 18 speakers confirmed We have short talk slots for grad students/post docs Meeting is free Nov 10-11 Synapses reign supreme Webpage to come Please RT @KateOCG @JasonSynaptic @SynapsesInSight @CAndrewFrank @HTB_soFLY @TedAbelneuro @PeriKurshan @NeuroBender
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Meet lab member graduate student Uchechi Okoroafor. She was featured on the Noon News at Uiowa tinyurl.com/4k4ststx Uchechi's thesis project is centered on developing gene therapy approaches to treat A-T @UIowaNeuro @uiowabiomed @UIowaACB
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CONGRATULATIONS to Jianing Li @jianing59966408 for being awarded an AHA Predoctoral Fellowship Jianing is solving decades old questions about the mechanisms controlling presynaptic Cav2 channel subtype abundance and organization @AHA_Research @UIGradCollege @UIowaNeuro @UIowaACB
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Interested in deciphering the fundamental questions in cell biology in health and diesease? Come to today's ACB seminar featuring Dr. Joerg Bewersdorf at 11:00 am Dr. Bewersdorf is a leader and pioneer in SMLM and their application in cell biology @UIowaACB @UIowaNeuro @IowaMed
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