Putting the FUN into T cell dysFUNction; unleashing the power of T cells to fight cancer!
New York, NY
Joined September 2015
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Congratulations on this amazing piece of work @philiplabvandy @MRudloffMSTP & team @VUMC_VCI 🎉👏. Paradigm-shifting findings! Lots to think about...BRAVO!!!
We are excited to share our work published today in @NatImmunol by @MRudloffMSTP, the whole @PhilipLabVandy team @VUMCDiscoveries, and in collaboration with our fantastic computational biology collaborators @dbetel and his group @WeillCornell. 1/7
nature.com/articles/s41590-0…
The SchietiLab retweeted
Enhancers are known to increase mRNA level. It is often assumed that this happens through increased transcript production. We deleted an endogenous enhancer of PTEN. We found that they also regulate poly(A) site cleavage activity and change expression of alternative 3′UTRs.
They did it again...another brilliant new paper from our colleagues @MingLiLab and collaborators! Congrats!!! @MSKCancerCenter
Repurpose T cell self-reactivity for #cancer #immunosurveillance . Check out our new study @Nature by brilliant @CancerResearch fellows Chun Chou and @XianZhang2016 with help from @chirag_msk @JoshSmithMDPhD and other @MSKCancerCenter colleagues. rdcu.be/cLLaG
Great opportunity! Terrific lab & amazing science 👇
Are you a soon-to-be college grad excited by tumor immunology? @philiplabvandy has an open Research Assistant position @VUMC_Cancer @VUMC_VCI @VUMCResearch in #Nashville! #researchjobs #PleaseRT tinyurl.com/4juvns9v
What are you doing on Friday 3/11 @ 2:30 ET?
👇
Tune in for @TheScientistLLC live webinar this Friday 3/11 2:30-4:00 pm ET with @Philiplabvandy @VUMC_VCI @VUMC_Cancer and Dr. Ben Youngblood @StJudeResearch to hear all about T cell dysfunction/exhaustion in cancer!
A Spotlight on T Cell Exhaustion the-scientist.com/sponsored-…
A must read: Oncogenes and Immune Evasion. Congrats to @jjroetman and @philiplabvandy !
1/ Excited to share our review: Viral and Cellular Oncogenes Promote Immune Evasion @oncogenejournal @jjroetman @VUGradSchool and MKI Apostolova @VanderbiltU
@VUMC_VCI @VUMC_Cancer @VUMC_Medicine
doi.org/10.1038/s41388-021-0…
ALT Viral and cellular oncoproteins inhibit the cGAS/STING pathway: (A) HPV E6 binds to STING to inhibit TBK1 and IRF3 binding, and (B) HPV E7 binds to IRF3 to prevent phosphorylation. (C) HBV polymerase prevents K63 ubiquitination of STING to block STING activation. (D) In non-viral cancers such as CRC and melanoma, the promoters of both cGAS and STING are methylated to prevent expression of these proteins. (E) HER2 associates with STING and recruits AKT to phosphorylate TBK1, which prevents the kinase from binding to STING and facilitating downstream signaling. Viral proteins are depicted in gold, and cellular proteins in purple, blue, and green.
Great opportunity! @MSKEducation @sloan_kettering
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What terrific news!!! Congratulations @MingLiLab - our very own 16th floor AAAS fellow!!!
Yes @tmhohl71 : handsome celebration preparations are in the works! 🎊🎉🍾🥂
Congratulations to @sloan_kettering immunologist and colleague Ming Li @MingLiLab on his election to AAAS Fellow! Richly, richly deserved - This calls for a handsome celebration. Paging @SchietingerLab ...
@JustinPerryPhD @huselab @MichaelGlickma1 @DiehlLab_MSK
The SchietiLab retweeted
A great way to start the new year is with a new paper! Was a lot of fun to write this piece in @ScienceMagazine with Ton Schumacher @NKI_nl and to discuss what we know and -more importantly- what we don't know yet about TLS in cancer bit.ly/Sci_abf9419
Happy holidays to all of you from the
@SchietingerLab @sloan_kettering
and all the best for 2022 🎄🎄🎄!!
Wow - what a terrific SKI talk from our very own @AgnelSfeir today. @sloan_kettering
Thanks CRI @CancerResearch for your support!
Thanks @sloan_kettering for supporting basic science wherever it leads! Thanks to all the terrific colleagues and collaborators @sloan_kettering and @WeillCornell @dbetel
@NIH #NIHHighRisk @CancerResearch
Published in @Nature and the result of research funded by the @NIH Director's New Innovator Award, SKI's @SchietingerLab found a stem-like T cell in type 1 #diabetes that could improve treatment of both autoimmune diseases, like #T1D, as well as #cancer. bit.ly/3E5vRam
The SchietiLab retweeted
Nature research paper: An autoimmune stem-like CD8 T cell population drives type 1 diabetes rdcu.be/cCmcK
The Schieti-Lab is excited to share our recent work by our graduate student @sofia_vgearty on autoimmune T cell programming in type 1 diabetes. Thanks to all our collaborators, especially @dbetel and team who made this work possible. @sloan_kettering disq.us/t/439lp6p
The competition is on... @DiehlLab_MSK @huselab @SunLab_Official @tmhohl71 @chaudhuj @MingLiLab @FlowMskcc @philiplabvandy
The SchietiLab retweeted
An awesome opportunity for URM students to gain invaluable research experience at our great institution! Let’s aim to make science as diverse as our city 🔬🧫🏙
🚨 Start your path to the PhD with MSK Bridge!
Calling recent grad students from underrepresented & underserved groups who are interested in biomedical careers to apply to our 2yr post-baccalaureate research program @sloan_kettering.
Lear more & apply: mskcc.org/education-training…
Thanks to #MSKfunfund @UshmaNeill @MSKEducation @sloan_kettering for a great night out. The Schieti-lab appreciates you!
