Psychedelics align brain activity with context “Our findings extend prevailing accounts that characterize the psychedelic state as desynchronized or entropically disordered by revealing structured, context-aligned organization in BOLD signal dynamics—a latent order harboured within temporal dynamics that time-averaging obscures—which emerges in proportion to the depth of self-dissolving and boundary-dissolving experience. This organization is distributed across networks but depends on the joint alteration of DMN and visual systems: the gradient end points that ordinarily segregate internal from external processing. When both are altered, that functional boundary dissolves, setting the conditions for brain activity to align with context, an integration that provides a neurobiological rationale for how structured settings can shape outcomes under psychedelics. That the felt boundary between self and world reorganizes when these dynamics shift implies that the boundary is not a fixed datum of conscious experience but a construction actively maintained by neural activity. Embeddedness—the continuity that emerges when this construction relaxes—may thus reveal less about what psychedelics add to consciousness than about what ordinary neural dynamics keep apart.” nature.com/articles/s41586-0…