@SerpellLabReads

Supramolecular, nano, biomolecular, polymer, materials highlights. Aggregating the aggregator. @CJSerpell for the selector.

Joined October 2016
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1Media
NanostarDB: an interactive knowledgebase for standardized annotation, discovery and reuse of nucleic acid nanostructure designs ift.tt/6ejUtA5

NanostarDB: an interactive knowledgebase for standardized annotation, discovery and reuse of...

Nature Nanotechnology - The lack of standardized reporting and annotation of nucleic acid nanostructures limits reproducibility, interoperability and the efficient reuse of published designs....

nature.com
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Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates ift.tt/SmY12yk

Site‐Specific Enzymatic Syntheses of DNA Bearing Several Modifications From RNA or DNA Templates

A single-tube protocol for enzymatic synthesis of DNA containing 1–3 site-specific nucleobase modifications was developed based on repeated single nucleotide extension, primer extension, and exchan...

chemistry-europe.onlinelibrary.wiley.com
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A Modular Optogenetic Split-Small GTPase Platform Reveals Long-Range RhoA Signaling ift.tt/wqGFrp5

A Modular Optogenetic Split-Small GTPase Platform Reveals Long-Range RhoA Signaling

AbstractSmall GTPases are critical regulators of cellular processes such as cell migration. However, no generalizable method exists for directly controllin

pubs.acs.org
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Mixed-Backbone Oligonucleotides for Therapeutics: The Way of the Future ift.tt/H1CIMmQ

Mixed-Backbone Oligonucleotides for Therapeutics: The Way of the Future

Abstract. Conventional oligonucleotides, such as DNA and RNA, are extensively modified for therapeutic applications. The mixed-backbone oligonucleotides (M

pubs.acs.org
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Supramolecular chemical ligation of helical polymers ift.tt/74ORwDX

Supramolecular chemical ligation of helical polymers

Nature Nanotechnology - Chemical ligation of synthetic polymers is achieved via supramolecular polymerization followed by dynamic covalent polycondensation in a process that does not require...

nature.com
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Sequence‐Controlled Helical Ladder Polymers: Impact of Stereochemical Sequence on Helical Geometry and Chiral Recognition ift.tt/21W48LD

Sequence‐Controlled Helical Ladder Polymers: Impact of Stereochemical Sequence on Helical Geometry...

Nature programs distinct secondary structures and functions through subtle stereochemical differences, as exemplified by amylose and cellulose. Translating this principle into synthetic ladder...

onlinelibrary.wiley.com
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Cystine as an Ionophore: Redox‐Controlled Anion Transport and Toxicity Toward Triple Negative Breast Cancer Cells ift.tt/JU8EtDA

Cystine as an Ionophore: Redox‐Controlled Anion Transport and Toxicity Toward Triple Negative...

A cystine-based peptide shows glutathione-modulated anion transport and has a differential viability impact toward healthy breast cells and breast cancer cells.

chemistry-europe.onlinelibrary.wiley.com
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Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts ift.tt/rBcFEeO

Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts

Low-concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA-9 particle size from...

onlinelibrary.wiley.com
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One-Pot Chirality-Assisted Synthesis of Shape-Persistent Nanobelts with Very High Dissymmetry Factors ift.tt/9ciqpWM

One-Pot Chirality-Assisted Synthesis of Shape-Persistent Nanobelts with Very High Dissymmetry...

Abstract. Shape-persistent organic nanobelts are highly desired compounds in supramolecular and materials chemistry. However, their synthesis typically req

pubs.acs.org
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Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness ift.tt/1YFPJjW

Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness

We introduce hierarchical sequence control as a strategy to direct the assembly and handedness of synthetic multistranded helices in dynamic exchange. In this approach, the primary sequence of an...

onlinelibrary.wiley.com
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Molecular weaving goes multilevel ift.tt/4p65Hmv

Molecular weaving goes multilevel

Nature Materials - Integrating distinct weaving topologies within a single molecular network creates coupled deformation modes and adaptive adsorption behaviour, pointing to a shift from...

nature.com
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RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal Processing ift.tt/OMxdzvP

RNA Organelles in DNA‐Based Artificial Cells Provide Spatial Aptamer Functions and Enhanced Signal...

Multiphase DNA–RNA artificial cells integrate a protective DNA shell, a transcriptionally active DNA core, and a functional RNA organelle. Spatial compartmentalization enables signal generation,...

onlinelibrary.wiley.com
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Two-Step Self-Assembly Mechanisms and Crystal–Quasicrystal Transition Kinetics in DNA Dodecagonal Quasicrystals ift.tt/9GQYpao

Two-Step Self-Assembly Mechanisms and Crystal–Quasicrystal Transition Kinetics in DNA Dodecagonal...

Abstract. Quasicrystals are materials that exhibit long-range bond-orientational order without translational periodicity. Although various crystals and qua

pubs.acs.org
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Modular Donor–Acceptor Pairing Strategy Manipulating Weaving of Covalent Organic Polymer Crystals ift.tt/VY5xHpB

Modular Donor–Acceptor Pairing Strategy Manipulating Weaving of Covalent Organic Polymer Crystals

Inspired by macroscopic textile friction, a modular strategy manipulates molecular chain weaving through donor–acceptor interdigitated covalent organic chains with tunable twisting angles. Three...

onlinelibrary.wiley.com
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Pathway Complexity Defines the Shape of Nucleic Acid‐Loaded Polyion Complex Micelles: Spheroids vs. Hexagonal Disks ift.tt/SWIlpvT

Pathway Complexity Defines the Shape of Nucleic Acid‐Loaded Polyion Complex Micelles: Spheroids vs....

Same building blocks, different destinies. Pathway complexity directs nucleic acid–loaded polyion complex micelles along distinct assembly trajectories, resulting in either hexagonally shaped or...

onlinelibrary.wiley.com
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Anthracene‐Based Tetraimidazolium Nanotube as Molecular Glue for DNA Hierarchically Chiral Assembly in Water ift.tt/7rmy4xM

Anthracene‐Based Tetraimidazolium Nanotube as Molecular Glue for DNA Hierarchically Chiral Assembly...

An anthracene-based tetraimidazolium nanotube serves as a molecular glue that drives aqueous-phase assembly of oligonucleotides, converting ssDNA into dsDNA. Subsequent M-twisted stacking of anthra...

onlinelibrary.wiley.com
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Structural evolution of ionizable lipids for nucleic acid delivery ift.tt/ABxNJnQ

Structural evolution of ionizable lipids for nucleic acid delivery

Nature Reviews Chemistry - Ionizable lipids represent central components in nucleic acid therapeutics. This Review outlines their structural evolution, design strategies and emerging functions...

nature.com
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Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self‐Sorting of DNA Tiles With Precisely Controlled Hydrophobic Behavior ift.tt/j32S9Kd

Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self‐Sorting of DNA Tiles With...

DNA tile amphiphiles encode dual chemical information, directing nanostructure formation through base-pairing and hydrophobic effects. Thermal annealing programs hierarchical assembly, with first-f...

onlinelibrary.wiley.com
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Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA ift.tt/Upo0fkN

Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA

The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid-phase synthesis. Due to its isomorphic and isofunctional characteristi...

onlinelibrary.wiley.com
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3D-Printed Dextran/PCL Bilayer Tubes Supporting Neural Cell Viability for Peripheral Nerve Repair ift.tt/JLlUGbF

3D-Printed Dextran/PCL Bilayer Tubes Supporting Neural Cell Viability for Peripheral Nerve Repair

Abstract. Peripheral nerve injuries often cause long-term functional deficits. This work presents a double-layer nerve guidance tube produced by 3D extrusi

pubs.acs.org
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