@SteensmaLab

Laboratory of Musculoskeletal Oncology at @VAInstitute studying NF1 tumor progression, sarcomas, breast cancer, and translational therapies. #EndNF

 Grand Rapids, MI
steensmalab.vai.org
Joined November 2019
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  • Followers226
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Congratulations to our newest graduate, Dr. Rae House! 🎓All the best for your postdoctoral research with the Lien Lab @eclien
Van Andel Institute (VAI)@VAInstitute18 Jun 2024
Congratulations to Alix Booms, Ph.D; Shelby Compton, Ph.D; and Rae House, Ph.D, who recently received their Ph.D. in molecular and cellular biology from Van Andel Institute Graduate School!
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To learn more about the role of Nf1 in pretumorigenic mammary stromal cells, check out our newest publication in @FrontCellDevBio 🐁 frontiersin.org/articles/10.… Congrats to first author @amenusha , @VAInstitute cores, & collaborators that contributed to this study 💐 #EndNF
Menusha Arumugam@amenusha13 May 2024
🎉 Excited to share part of my PhD work with @SteensmaLab is now published in @FrontCellDevBio 🧬 We showed that germline Nf1 mutation in rats disrupts mammary adipocyte differentiation & increases collagen deposition prior to breast cancer formation 🐁 frontiersin.org/articles/10.…
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Registration closes May 10 for the VAI Epigenomics Workshop. This 3-day, hands-on, problem-based experience will immerse PhD students in the latest epigenomics research and techniques. Please share with anyone who might be interested! vai.org/event/vai-epigenomic…
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A new doctor in the house 🎉 Congratulations to Dr. House for successfully defending her dissertation today🥂
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Excited to share our newest publication in @oncogenejournal 🎉 “p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs” Highlights below 🧵 Read full paper here: nature.com/articles/s41388-0…

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

Oncogene - p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

nature.com
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p53 loss drives a selective clonal advantage in MPNST by promoting acquired resistance to targeted kinase inhibition and modulating lineage plasticity pathways.
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Congratulations to first author @jamie_grit , @sydney51605 + other coauthors, and collaborators! 💐 #EndNF
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Steensma Lab retweeted
JamieGrit@jamie_grit8 Mar 2024
Replying to @SteensmaLab
authors.elsevier.com/a/1ijZa… Read the full article for free here!
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In our latest publication in @theJIDJournal, we developed a patient-derived explant model for cutaneous neurofibromas that can be leveraged for mechanistic studies and preclinical drug testing.
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As proof of principle, we employed our novel explant model to extend our prior findings regarding differences between downstream RAS-mediated inflammation in CNFs. We found that ex vivo glucocorticoid treatment was able reduced inflammation in these explants.
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Congratulations to first author @jamie_grit and coauthors! 🎉 Read more here: pubmed.ncbi.nlm.nih.gov/3839…

Ex Vivo Patient-Derived Explant Model for Neurofibromatosis Type 1-Related Cutaneous Neurofibromas...

Cutaneous neurofibromas (CNFs) are benign tumors that occur in the dermis of individuals with the inherited tumor predisposition disorder, neurofibromatosis type 1. CNFs cause disfigurement, pain,...

pubmed.ncbi.nlm.nih.gov
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Excited to share a new publication from our lab - NF1 deficiency drives metabolic reprogramming in ER+ breast cancer. Read more here; sciencedirect.com/science/ar… Highlights below 🧵
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Highlights: - NF1 deficiency -> metabolic reprogramming in ER+ BC - NF1-driven metabolic reprogramming = OXPHOS constraints, glutamine TCA influx, & lipid pool expansion - NF1-deficient ER+ BC cells have increased sensitivity to combined RAS + triglyceride synthesis inhibitors
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Congratulations to graduate student, Rae House, on her first first author publication! 🎉 Thank you to our funding sources, coauthors, collaborators, and @VAInstitute cores for all their contributions to this project.
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Welcoming our newest cohort! Welcome to our 12 newest students in our PhD program! #PhDinMolecularandCellularBiology @VAInstitute #biomedicalsciences #futurebiomedicalleaders 🧬🧫🔬🧪
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How we feel about getting the official Notice of Award for @pat_dischi’s successful F99/K00 🎉 congratulations Patrick!
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Congratulations to our two new graduates - Dr Lauren McGee and Dr Menusha Arumugam! 🎓🎓 Both are moving on to postdoc positions; Lauren @sydney51605 with the LeBlanc Lab at NIH and Menusha @amenusha with the @Hilgendorf_Lab at U of Utah. We will always be rooting for you 💙
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All the love and support I had through the past 6 years was condensed into such a special graduation day! Officially a @SteensmaLab and @VAInstitute Graduate School alumni! 💙🤍 Excited to move out west this summer and start the next stage of my journey with the @Hilgendorf_Lab
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Having a great time talking science and meeting cool people at the Mammary Gland GRC! @Mammary_journal @GordonConf #MGBGRC2023
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