Study into the Reversal of Septic Shock with Beta Blockade (Landiolol)
NIHR EME funded trial
Joined December 2018
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STRESS-L trial results published today in JAMA and also presented at ESICM #LIVES2023 by @Whitehouse_ICU. Thank you to all who contributed to the research.
Among patients with septic shock with tachycardia treated with norepinephrine for more than 24 hours, an infusion of the β-blocker landiolol did not reduce organ failure as measured by the SOFA score in the 14 days from randomization.
ja.ma/3s3V2t4
#ESICM #LIVES2023
STRESS-L Trial retweeted
Second paper in a week!
Results of Cytokines measured during the @StressLTrial
link.springer.com/article/10…
STRESS-L Trial retweeted
Really interesting and balanced editorial from JAMA about @StressLTrial
(Although Para 4; sentence 2 "Whitehead" should read Whitehouse 😭)
From the editorial by Steven M. Hollenberg on The STRESS-L RCT
“β-Blockade may have beneficial effects in some areas, such as inflammation and metabolism, but potentially deleterious effects in others.”
Published w/#LIVES2023 ja.ma/3Qu3hYV
STRESS-L Trial retweeted
I'm pleased to say that there will be some news on @StressLTrial soon
Delayed announcement here - live announcement on critcare.social
Watch those spaces!
#icu #septicshock #betablocker
A warm welcome back to Addenbrookes Hospital @CUH_NHS who restarted recruitment to STRESS-L today! Thanks for all your hard work in getting the trial back up and running at your site @PPolgarova @jamvar 😀#septicshock #whywedoresearch #teamwork #nihr
New @StressLTrial database training taking place:
Today 10:00 - 10:30
Tues 28 Sept 14:00 - 14:30
Sessions will be recorded for sites unable to attend. Please contact @WarwickCTU trial team for joining details.
Many thanks!
📢 The @StressLTrial database and IVR line will be temporarily unavailable TODAY between 18:00 - 19:00 because of updates to the system. Sorry for any inconvenience caused. All sites have been alerted via email. Please share with relevant team members. Thank you in advance.
STRESS-L Trial retweeted
TODAY is #WorldSepsisDay - join the global movement to raise awareness for #sepsis, a silent killer hiding in the #covid19 pandemic.
Awareness save lives – and it's not too late to become involved 👇👇👇
worldsepsisday.org/news/2021…
STRESS-L Trial retweeted
1 in 5 deaths globally is associated with #sepsis. Do you know the symptoms, sources, and risk groups of sepsis? This #WorldSepsisDay, share this video with a loved one - it could save their lives! youtu.be/NsPDjOX8QHA
STRESS-L Trial retweeted
Delighted to link our advanced clinical practitioners with research delivery through the API scheme @StressLTrial @NIHR70at70 well done Andy !
A big thank you and congratulations to Andy Simmons, ACP at Heartlands Hospital, who has recently been accepted on to the STRESS-L Associate PI Scheme! Andy brings valuable critical care research nurse experience to the role @teresamelody1 @yeung_joyce @UHBCriticalCare @uhbtrust
STRESS-L Trial retweeted
Welcome Andy!
Are there any other sites out there?
#AssocPI
A big thank you and congratulations to Andy Simmons, ACP at Heartlands Hospital, who has recently been accepted on to the STRESS-L Associate PI Scheme! Andy brings valuable critical care research nurse experience to the role @teresamelody1 @yeung_joyce @UHBCriticalCare @uhbtrust
A big thank you and congratulations to Andy Simmons, ACP at Heartlands Hospital, who has recently been accepted on to the STRESS-L Associate PI Scheme! Andy brings valuable critical care research nurse experience to the role @teresamelody1 @yeung_joyce @UHBCriticalCare @uhbtrust
*NEW*👉STRESS-L Publication Policy allows your site to propose 1 author for the writing committee for the published STRESS-L paper at the end of the trial if you have recruited 10 patients. If you manage to recruit 20 patients, you can propose 2 authors @Whitehouse_ICU @CRN_WMid
122 total patients recruited. Thank you to all involved for your continued hard work. Check below if a patient is eligible for STRESS-L👇Randomisation Line: 02476 932036
#septicshock #icuresearch #managedrecovery
@Whitehouse_ICU @CRN_WMid @WarwickCTU @NIHRresearch @EPPiC_Warwick
📢NIHR Associate PI scheme now available @StressLTrial - please consider & encourage trainees to take part at your centre to gain valuable experience in trial delivery: nihr.ac.uk/documents/associa…
Applicants can register after approval from their local PI docs.google.com/forms/d/e/1F…👇
A warm welcome back to @HullHospitals who restarted recruitment today. We look forward to working with the team again to help us deliver this important septic shock trial #whywedoresearch #NIHRmanagedrecovery #septicshock #ICUresearch #clinicaltrials
A total of 1⃣2⃣1⃣ patients recruited to STRESS-L. Thank you to our patients, families and sites for your continued support.
As a reminder we are part of the NIHR Managed Recovery Programme. Get in touch today to discuss the support available 👉@CRN_WMid @WarwickCTU
STRESS-L Trial retweeted
That's great to hear! Welcome back to @StressLTrial
Good luck with screening and get in touch if you have any questions
Warm welcome back to @YorkResearch @icu_portsmouth @uhbwNHS who recently restarted screening.
Check below if a patient is eligible for STRESS-L?👇
☎️Randomisation Line: 02476 932036
#septicshock #icuresearch
@Whitehouse_ICU @CRN_WMid @WarwickCTU @NIHRresearch @EPPiC_Warwick
Warm welcome back to @YorkResearch @icu_portsmouth @uhbwNHS who recently restarted screening.
Check below if a patient is eligible for STRESS-L?👇
☎️Randomisation Line: 02476 932036
#septicshock #icuresearch
@Whitehouse_ICU @CRN_WMid @WarwickCTU @NIHRresearch @EPPiC_Warwick
STRESS-L Trial retweeted
Thanks for all of you work on this Paul @DarkNatter .
@StressLTrial is grateful for all the support it is getting. We have also become part of the Associate PI Scheme.
Update on NIHR Managed Recovery. For Critical Care as Managing Specialty, 3 multi-centre RCTs have been selected for delivery support to date: @StressLTrial @CRN_WMid @HAP_Diagnostics @NIHRCRN_nthames and @AdaptSepsis @NIHRCRN_gman . Please support these trials for delivery