@TheFrankelLab

Frankel lab, Imperial College London. #microbiome #hostpathogen #t3ss - Tweets from lab members.

 Imperial College London
imperial.ac.uk/people/g.frankel
Joined October 2018
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  • Following214
  • Followers1.2K
Great visit to Tokyo University. Thank you Hideaki and Chiho for wonderful hospitality.
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We are happy to share our recent publication linking severe infectious colitis with reduced migration of neutrophils to the infection site, leading to their accumulation in the submucosa where they undergo NETosis causing tissue damage: sciencedirect.com/science/ar…
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Do you want to know more about the secrets of bacterial conjugation efficiency & specificity? Are you familiar with @wenwenlow 's previous work & cant wait to check out her latest? Have a look at our new publication on TraN-OMP pairs in conjugation! 🦠➡️🦠 pubmed.ncbi.nlm.nih.gov/3698…
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It was a great pleasure to talk on bacterial conjugation at IISc Bangalore, not to mention the fantastic hospitality of Sandhya Visweswariah and Varsha Singh. Many thanks to the Hamied Foundation for supporting this trip.
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Congratulations to Wen Wen for passing her PhD viva with flying colours; thanks to Gabriel and @thelowlab for interrogating her on bacterial conjugation, not to mention Josh's incredible chicken rice to celebrate after.
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Congratulations to Josh, who just passed his PhD viva! 🎉🥳 And it now goes full circle, with @GordonDougan1 doing his last PhD viva as an examiner in the centre he inaugurated & in the same office he occupied @CMBI_Imperial
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The face of happiness and relief on a student's face after PhD thesis submission! Congratulations @wenwenlow 🎉🥳
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These findings have many implications and, importantly, demonstrates how species specificity is mediated during conjugative transfer of an important group of plasmids. We liken these TraN-OMP interactions during MPS to different plugs and sockets that link bacteria together 9/
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By analysing more than 800 plasmids, their host distribution largely mirrored the in vitro data. Plasmids tend to be found in species which participate in MPS via their encoded TraNs. So, while MPS is not essential during conjugation, it certainly appears to be consequential 8/
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These interactions are so specific that they have a species-specific effect on conjugation. For eg, while OmpA homologues in E. coli and S. Typhimurium are recognized by TraNγ, homologues from K. pneumoniae and E. cloacae are not. 7/
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