2025 put health systems under enormous pressure, from conflict and climate shocks to rising debt and unprecedented cuts to development assistance. Yet amid that historic uncertainty, countries continued to expand protection against preventable disease, reach more children and invest more of their own resources in immunisation. Gavi’s latest Annual Progress Report captures the scale of that progress, and the work that still lies ahead. Scroll down through eight numbers that help tell the story of 2025, and read more about what sustained investment in vaccines has made possible on VaccinesWork: bit.ly/4jJbqrh

Vaccines are often said to be victims of their own success because people forget how devastating these preventable diseases can be. But when vaccine rates fall, these forgotten diseases can return with a vengeance, with devastating consequences: bit.ly/482xuWU Via The Conversation

Malaria elimination can sound like an impossible goal, but in Ghana, it’s starting to look increasingly tangible. Sustained investment in vaccines, prevention, treatment and community engagement has led to a 98% reduction in deaths since 2011, putting elimination “within reach.” Read the full story: bit.ly/4e80yQg

Preparing to rollout next-generation #tuberculosis vaccines takes careful planning to shape policies, inform implementation strategies and decide who to prioritise. Two South African experts dive into the logistics of ensuring these new vaccines will have the maximum possible impact: bit.ly/47sZnr5

The XFG variant, AKA the ‘American COVID’ variant, has been circulating for more than a year and is currently the most common form of SARS-CoV-2 globally. Here's everything you need to know: bit.ly/4eHSl5w

More than 1,800 measles cases, one targeted response. Malawi’s Ministry of Health is bringing vaccines into schools and working with parent-teacher associations and religious leaders to close immunity gaps: bit.ly/4ySHdeh @health_malawi

As devastating flash floods wreaked havoc in Nepal, dedicated health workers stepped up to prevent a deadly cholera epidemic with an effective vaccination campaign: bit.ly/4BwbktQ

We’re delighted to be recognised as a “Very High Performer” for the sixth consecutive year in the latest Global Health 50/50 annual report. Thank you @GlobalHlth5050 for recognising our commitment to gender equity at both the programmatic and organisational levels: bit.ly/3VVxtkW

How can studying healthy gut bacteria uncover clues on how to tackle the growing threat of antibiotic resistance? Here’s what one disease ecologist discovered when studying residents of a densely populated urban informal settlement in Nairobi, Kenya: bit.ly/4jpPvFH Via The Conversation

Equity in health isn't just an ideal, it's actively happening. In 2025, DTP3 coverage reached 82% in Gavi-supported countries, closing the gap with the global average (85%) to a historic low. Read the full breakdown on this and other 2025 achievements in immunisation: gavi.org/progress-report

We know vaccinated children have better education outcomes, but could classrooms be the key to higher vaccination rates? In Malawi, school-based vaccinations supported by parent-teacher associations are proving effective in the battle against a measles resurgence: bit.ly/4ySHdeh

Trust in science is falling fastest among people facing financial insecurity. A new global survey from @wellcometrust spanning 140 countries found that people who feel left behind are also less likely to say they trust science, especially when healthcare and the benefits of research feel out of reach. Read the full story: bit.ly/4inkUaK via @scidevnet