Official account Section Translational Cancer Epigenomics @TMO_Heidelberg @NCT_HD @DKFZ, #epigenomics, #hematopoiesis, #JMML, #singleCell, #precisiononcology
Heidelberg, Deutschland
Joined June 2022
- Tweets228
- Following1.3K
- Followers668
- Likes465
Pinned Tweet
🧵 NEW PAPER in @BloodJournal!
Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? #AML #Epigenetics
Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇
Translational Cancer Epigenomics retweeted
‼️ Pre-print alert from the Lipka lab ‼️
Our latest work “Hierarchical classification of hematologic malignancies using epigenetic and genetic information” is now online!
biorxiv.org/content/10.64898…
Thanks to all colleagues who contributed to this work! 🙏
Translational Cancer Epigenomics retweeted
Decades of research have revealed the intricacies of how dendritic cells (DCs) function, but fundamental questions remain about how this group of cells develops in humans and how this process goes awry in disease. A thread on our new work! (1/9)
biorxiv.org/content/10.64898…
Translational Cancer Epigenomics retweeted
📢Another exciting seminar on CCEC, scheduled on Friday 6thJun@3PM,UKtime with Alvaro Rada Iglesias @IBBTEC Cantabria.
Alvaro will discuss: Enhancer-Promoter contact, a key feature in gene regulation, how and why?? link2join us06web.zoom.us/webinar/regi…
@ShuchiChromaBio
@activemotif
12/ To summarise:
→ IDH1 is highly expressed in myeloid progenitors (unlike IDH2)
→ Mutant IDH1 epigenetically silences Cebpe → neutrophil block
→ The block persists after IDH1 inhibition alone
→ IDH1i + hypomethylating agent fully rescues the defect
13/ Huge congratulations to first author @MariamHakobya20 and all collaborators and a big THANK YOU for all your efforts and support throughout the project! 🎉
📄 Paper link 👇
doi.org/10.1182/blood.202503…
#AML #Leukemia #IDH1 #Epigenetics #Hematology #BloodCancer @DKFZ @NCT_HD
Translational Cancer Epigenomics retweeted
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
Translational Cancer Epigenomics retweeted
I can only agree with that!
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
Translational Cancer Epigenomics retweeted
Now online: Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…
Translational Cancer Epigenomics retweeted
Check out our latest story science.org/doi/10.1126/scie…! Huge thanks to @GauravA_UK and the @bloodgenes lab for driving this work forward together with us. This was a great team effort with outstanding collaborators @_ruslansoldatov, @AbdelWahablab, and @AlexBickMDPhD.
