@mp_hartmann

Scientist @DKFZ @NCT_HD @TMO_Heidelberg @TransCanEpi #epigenetics #stemcells #leukemia #multiomics #precisiononcology #oncofetal #reprogramming #plasticity

 Heidelberg, Germany
translational-cancer-epigenomics.de
Joined November 2020
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NEW PREPRINT: scIRES-seq brings simultaneous single-cell multi-omics to circulating tumour cells (CTCs): immunophenotype, genetics, DNA methylation and gene expression, linked within the same cells. doi.org/10.64898/2026.10.07.…
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...and to Maria-Veronica Teleanu, Wolf-Karsten Hofmann, Steffen Schmitt, Jan-Philipp Mallm, @StefanFrohling , Tobias Boch and @dblipka1 !
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Grateful to the patient, clinical teams, core facilities and funding who made this work possible. @TransCanEpi @TMO_Heidelberg @DKFZ @NCT_HD @unimedizinma @ResearchLifesci
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Check out our latest preprint on epigenetic classification of leukemias!
Daniel Lipka@dblipka1Jul 6
‼️ Pre-print alert from the Lipka lab ‼️ Our latest work “Hierarchical classification of hematologic malignancies using epigenetic and genetic information” is now online! biorxiv.org/content/10.64898… Thanks to all colleagues who contributed to this work! 🙏

Hierarchical classification of hematologic malignancies using epigenetic and genetic information

Molecular testing in hematology requires different assays for disease subgroup identification, risk stratification and selection of appropriate treatment regimens. Yet, molecular tests are not...

biorxiv.org
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Editors’ Pick by Cancer Research Catalyst @AACR RAS-driven plasticity and oncofetal reprogramming as a key mechanism and vulnerability in JMML. The article is freely available for a limited time: aacr.org/blog/2026/03/27/edi… #hematology #oncology #epigenetics #development

Editors’ Picks, March 2026: Pediatric Leukemia Development, Low-dose Tamoxifen Use, and More

In March, AACR's journals editors highlighted studies on the development of pediatric leukemia, the use of low-dose tamoxifen, and more.

aacr.org
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Excited to share our work at the 2026 #ISEH Mini Symposium! "Beyond the maturation block: oncofetal reprogramming & stem cell plasticity in pediatric leukemia" Great lineup incl. @beth_psaila, Simón Méndez-Ferrer & Jian Xu Join us April 16: iseh.org/Webinars-Events/Min… @ISEHSociety
ISEH@ISEHSocietyMar 26
We are excited to announce the full Mini Symposium program featuring the short talks selected from submitted abstracts! Don't miss the chance to view groundbreaking research and choose the top short talk. View the full program and register ➡️ iseh.org/Webinars-Events/Min…
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Read the March Editors' Pick: Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…

Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile...

Reconstruction of leukemic ontogeny reveals that JMML stem cells mature postnatally, then reactivate fetal gene expression, including elevated CD52—a druggable target in high-risk disease.

aacrjournals.org
AACR
@AACRMar 30
The March edition of Editors’ Picks from AACR journals includes studies on pediatric leukemia development, awareness of alcohol as a carcinogen, and more. Learn more on the #AACRBlog: brnw.ch/21x1aEw
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Mark Hartmann retweeted
AACR
@AACRMar 30
The March edition of Editors’ Picks from AACR journals includes studies on pediatric leukemia development, awareness of alcohol as a carcinogen, and more. Learn more on the #AACRBlog: brnw.ch/21x1aEw
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Mark Hartmann retweeted
Rhys Morgan@RhysMorganLabFeb 9
We're hiring a new 3 yr postdoc! Come join us at @SussexUni for exciting new @CR_UK funded project targeting RUNX1 mutations in CML in a highly supportive research environment within @Sussex_BCR @SussexLifeSci @BiochemBiomedUS @Sussex_Cancer Apply 👇, advert closes 8th March.
Sussex Recruitment@SussexUniJobsFeb 9
New post: Research Fellow in Biochemistry & Biomedicine (Fixed Term) Ref: 43139 Closing Date: 08 March 2026 To apply visit: jobs.sussex.ac.uk/job/4fee4e…
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I can only agree with that!
Elvin Wagenblast@Elvin_WagFeb 5
Grateful to @JianXuLab for this perspective highlighting how oncogenes, developmental ontogeny, and cellular plasticity intersect in pediatric leukemia, alongside the JMML study by @mp_hartmann and @dblipka1. @BCD_AACR @CD_AACR aacrjournals.org/bloodcancer…
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Mark Hartmann retweeted
Blood Cancer Discovery@BCD_AACRFeb 4
Now online: Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia doi.org/10.1158/2643-3230.BC…
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New Spotlight in @BCD_AACR #Oncogene × #Ontogeny × #Plasticity shape leukemia biology & therapy response. Two complementary studies show: mutations alone don’t explain disease behavior—developmental state and cellular plasticity matter. aacrjournals.org/bloodcancer… #leukemia

A Triumvirate of Transformation: Oncogene, Ontogeny, and Plasticity

Summary:. Cancer cells display extensive heterogeneity that influences therapy response and clinical outcome, yet the underlying mechanisms remain incompletely understood. Recent studies reveal that...

aacrjournals.org
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Same mutation ≠ same leukemia. @Elvin_Wag et al. @CD_AACR • fetal HSCs readily transform • postnatal HSCs become resistant • fetal programs create vulnerabilities Ontogeny matters: state-of-origin shapes biology & therapy response. doi.org/10.1158/2159-8290.CD… #pediatric #AML

Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia

Leukemias initiated at different developmental stages follow distinct biological paths, showing that mutation timing, not just mutation identity, governs disease behavior and treatment response in...

aacrjournals.org
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JMML stem cells aren’t epigenetically “stuck” in a fetal state. They mature postnatally—yet show striking transcriptional plasticity, with oncofetal reprogramming in high-risk disease, challenging the classic “maturation block” model. doi.org/10.1158/2643-3230.BC… #JMML #epigenetics

Molecular Plasticity Results in Oncofetal Reprogramming and Therapeutic Vulnerabilities in Juvenile...

Reconstruction of leukemic ontogeny reveals that JMML stem cells mature postnatally, then reactivate fetal gene expression, including elevated CD52—a druggable target in high-risk disease.

aacrjournals.org
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Thank you @mtdialog for featuring our study: Frühkindliche Leukämie: Fetale Programme reaktiviert - MT-Dialog mtdialog.de/news/artikel/fru… #Kinderkrebs #Leukämie @DKFZ @NCT_HD

Frühkindliche Leukämie: Fetale Programme reaktiviert

Bei der frühkindlichen Leukämie ging man davon aus, dass Stammzellen in fetalen Entwicklungsprogrammen stecken bleiben. Doch es zeigt sich, dass diese reaktiviert werden.

mtdialog.de
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