Bioinformatician, PhD interested in ribosome profiling for studying translation and discovering novel proteoforms; gene annotation; RNAomics

Cork, Ireland
Joined February 2018
Alla Fedorova retweeted
New paper from Gab, myself, Éric and Jean-Phillipe. Here we conduct a metazoan scale phylogenomic analysis of intrinsic apoptotic actors and show divergence across metazoa. academic.oup.com/evlett/adva…
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Alla Fedorova retweeted
New multi-institute £5.5million @wellcometrust funded PARADIGM project to improve diagnosis in rare disease. It will couple functional genomics data with clinical and bioinformatics expertise to empower diagnosis and discovery in genomic medicine paradigmgenomics.org/
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Alla Fedorova retweeted
Ribo-Seq has unearthed thousands of fascinating cases of translation complexity over the last decade. Through the exploration of Ribo-Seq datasets it became clear that a more accurate representation is required to help us better understand this complexity. #Translation #RiboSeq
Ribosome Decision Graphs for the Representation of Eukaryotic RNA Translation Complexity biorxiv.org/cgi/content/shor… #biorxiv_genomic
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Ribosome Decision Graphs for the Representation of Eukaryotic RNA Translation Complexity biorxiv.org/cgi/content/shor… #biorxiv_genomic
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Current stipends for PhD researchers in Ireland just aren't enough. Ireland is ranked LAST GLOBALLY in terms of PhD Stipend to cost of living ratio, scoring 0.58. Meaning the current ANNUAL PhD stipend covers living costs for less than 7 months. @DeptofFHed #PGRsDeserveBetter
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In cancer, so many - here’s our example in #prostatecancer showing that mRNA-protein correlations at the proteome level get worse when disease progresses. Translational control is so much more important in also cancer than currently given credit for. nature.com/articles/s41467-0…
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Alla Fedorova retweeted
1/ My favourite gene has 15 transcripts, which one should I use for further analysis? To report the position of variants? To design primers for? 🤯 This #tweetorial will show you how to filter and prioritise transcripts… 🧵 #genomics #bioinformatics #Ensembltraining 🧬
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Alla Fedorova retweeted
Want to know which cell lines are most like ovarian cancer? Check out our latest publication, led by PhD student @aideen_mccabe Investigating the suitability of in vitro cell lines as models for the major subtypes of epithelial ovarian cancer frontiersin.org/articles/10.…
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Alla Fedorova retweeted
Make a good paper a Cell paper with our CELL TITLE Transformer: Actual title: Trypanosoma brucei mitochondrial proteins TbTim17 and TbTRAP1 are biotinylated CELL TITLE: Single-cell multi-omics and lineage tracing to dissect cell fate decision-making
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Alla Fedorova retweeted
Great to see productive discussion on how to improve conditions for PhD researchers from both academic and post graduate leadership. Sincerely hope that the point made here in paragraph 3 regarding non-EU researchers is not overlooked in the ongoing review. @SimonHarrisTD
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Alla Fedorova retweeted
Check out our new opinion paper ‘The constructive function of apoptosis: More than a dead-end job’ And watch this space for weird apoptosis things in weirder animals. tinyurl.com/yrh59akr
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IT HAS HAPPENED!!!
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Alla Fedorova retweeted
It’s impossible to please everyone. We spend so much time and effort, but people are going to disagree with you no matter what you do or what stance you take. Don’t try to please everyone. In the end, the only thing that really matters is pleasing two reviewers
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Alla Fedorova retweeted
Mentor editing manuscript xitter.cf/SkillsLevel/status/157…
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My PhD thesis watching me work on yet another side project
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Located in a country 🇮🇪 that has no Cryo-EM, Atkins lab has been key to preparing samples for the highest resolution Bacterial (1.55A, this study) and Mammalian ribosomes (2.2A, Bhatt, Scaiola et al. 2021) available to date. The definition of "Unprecedented detail" 👇
Check out our first preprint of the 1.55 Å cryo-EM structure of the bacterial translating ribosome!! An awesome collaboration between our group at @UVA with the @SimoneMattei19 group at the Imaging Centre at @EMBLHeidelberg and the Atkins group at @UCC biorxiv.org/content/10.1101/…
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Alla Fedorova retweeted
This data is so grim not even making a plot could make me feel better about it, but I tried...
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