Postdoc @doudna_lab | PhD in nanomedicine @bme_uoft & @TheChanLab | Fan of all things whimsical
San Francisco, CA
Joined September 2016
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Wayne Ngo retweeted
VIPR is now out in @ScienceMagazine!
What started with a mysterious RNA led us to an unexpected way of recognizing DNA, as well as some clues to CRISPR’s origins.
So happy to share these two papers with an incredible team. Links below; original discovery thread here ↓
Wayne Ngo retweeted
I am so excited to share our new paper in @Nature: the first programmable, site-specific integration of a large DNA payload into T cells in vivo.
A single IV injection results in therapeutic levels of TRAC-targeted CAR T cells in multiple models.
nature.com/articles/s41586-0…
a 🧵
Wayne Ngo retweeted
Amplified genome editing by in vivo editor production biorxiv.org/content/10.64898… #biorxiv_bioeng
Wayne Ngo retweeted
Excited to share our newest paper on @nchembio where we present temporal MultiMap for dynamic neighborhood mapping. Our sincere gratitude to all our collaborators @WayneNgo1 , Yu-Ting, @harrychembio , @katherine_susa for their hard work!
nature.com/articles/s41589-0…
Wayne Ngo retweeted
How do nanoparticles enter the tumour?
In our latest study @NatureNano, we found tumour endothelial cells bring NPs in mostly using macropinocytosis & interestingly, macropinocytosis membrane ruffling is elevated in tumour vs healthy vessels 🧐@TheChanLab
nature.com/articles/s41565-0…
Wayne Ngo retweeted
🚨🚨New Paper🚨🚨
Ever wonder where EPR came from?👀
Matt et al. describe the history and evidence for the EPR effect and its impact on cancer nanomedicine. They also discuss a new theory termed the Active Transport and Retention (ATR) principle.🌶️🌶️🌶️
nature.com/articles/s44222-0…
Wayne Ngo retweeted
🚨🚨🚨New paper🚨🚨🚨
@Matt___Nguyen et al. found that NPs exit solid tumours through the lymphatics in a size dependent mechanism, and proposed a new mechanism of NP delivery to tumours called the Active Transport and Retention (ATR) principle 🥵🌶️
tinyurl.com/4p7ymkjn
Wayne Ngo retweeted
🔥🚨@zacplin and @WayneNgo1 here to post Chan Lab's first paper of 2023🔥🚨
We found that nanoparticles can pick up platelet factor 4 when they pass through injury sites. This enables nanoparticle binding to endothelial cells 🔎 (1)
pubs.acs.org/doi/10.1021/acs…
I defended my PhD (in person) yesterday!!!
Thank you @TheChanLab for the wonderful 6 years!
HUGE congrats to our newest PhD graduate Dr @WayneNgo1 on his successful defense yesterday! 🤩
Big thanks also to the committee members Drs @gzheng74 @jflovell @GartonLab & Moffat 🥳
Wayne Ngo retweeted
🤩@WayneNgo1 & @jamielywu are here to share their paper, Identifying cell receptors for the nanoparticle protein corona using genome screens, in @nchembio!
📜:nature.com/articles/s41589-0…
@DonnellyCentre @bme_uoft
Wayne Ngo retweeted
Our PhD student @WayneNgo1 is at
@KeystoneSymp this weekend - check out his poster and talk if you're there! 👋😎
#KSPrecisionGene22
Wayne Ngo retweeted
ADDR in press: "Why nanoparticles prefer liver macrophage cell uptake in vivo"
By Warren C.W. Chan & coworkers @bme_uoft @TheChanLab
#nanoparticle #macrophages #MononuclearPhagocyteSystem
doi.org/10.1016/j.addr.2022.…
Wayne Ngo retweeted
Very grateful for the support and opportunity to do amazing science! Big thanks to @space_potate , @WayneNgo1 and Dr. Chan for the mentorship and for fostering a great lab environment to learn from 👩🏻🔬
Meet the inaugural recipients of NMIN's Undergraduate Studentships in #nanomedicines Research & read about their projects
@TheChanLab @ColinRossUBC827 @UBC @UofT
nanomedicines.ca/2021/06/21/…
Wayne Ngo retweeted
Our @chemuoft PhD student @johnny_yw_zhang is presenting his @J_A_C_S paper, "An Analysis of the Binding Function and Structural Organization of the Protein Corona", at @NMIN_NCE's Poster Presentation Series on March 25 👨🔬 Check it out! Info below.
Paper: pubs.acs.org/doi/abs/10.1021…
Join us on March 25 for the 1st round of NMIN's new Poster Presentation Series as 4 trainees present on their #nanomedicine research.
Info & register: bit.ly/30P1F1l
Had a nice conversation with @TheVarsity about our DNA protein nanoparticles. Excited to see what our technology will inspire! Read here: thevarsity.ca/2020/11/29/dna…
Wayne Ngo retweeted
I cannot agree with Prof. Doudna more: it's all about *DELIVERY* 🚚🧬✂️ cc: @WayneNgo1 @abdullah_m_syed #CRISPR
Happy to share my first first author paper! Couldn't have done it without help from @ben_stordy, James and @thermofisher.
🤩Our newest study led by @WayneNgo1 is out in @J_A_C_S! We encapsulated precise ratios of small molecules in protein #nanoparticles using specific DNA interactions. 💊🚚 Thanks to co-authors @ben_stordy & @thermofisher.🥳 cc: @bme_uoft @DonnellyCentre
pubs.acs.org/doi/10.1021/jac…
