@ZepengMu

牟泽鹏 Postdoc @soumya_boston @BrighamWomens @broadinstitute; PhD @yang_i_li @UChicago; BS @UCAS1978

 Boston, MA
zepengmu.netlify.app
Joined August 2016
  • Tweets75
  • Following864
  • Followers272
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Zepeng (Phoenix) Mu retweeted
Yang I Li@yang_i_liOct 24
Reference-free isoform discovery is here! Torino learns RNA processing events directly from RNA-seq coverage, no annotations required. See how we used it to study isoform evolution and link unannotated isoforms to disease. Led by @cfbuenabad. doi.org/10.64898/2026.10.21.…
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1/11 We are excited to share Dynema, a new method for ​​efficient genome-wide mapping of reproducible, context-dependent eQTLs at true single-cell resolution w/ @soumya_boston and @aparnanathan biorxiv.org/content/10.64898… tldr it finds reproducible eQTLs quickly and accurately!
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Zepeng (Phoenix) Mu retweeted
Cell@CellCellPressAug 24
New issue is out👉cell.com/cell/current Introducing DANDELION, a method to identify core genes of complex traits, the cover depicts a lung adorned with dandelions and background patterned with ATCG sequences representing application of the framework to reveal new asthma genes
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Zepeng (Phoenix) Mu retweeted
Xuanyao Liu@XuanyaoLiuAug 11
Our paper is out today in Cell, "Trans-regulatory gene mapping prioritizes disease drivers in asthma", cell.com/cell/fulltext/S0092… 🎉 GWAS hands us thousands of disease-linked variants, but the genes that actually drive the disease often aren't the ones sitting at those variants.
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Excited to see this wonderful work from my lab mate @YoshiTomofuji, among the first to utilize our recent method CRAFTseq to dissect the mechanism of a surface protein QTL for CD40, which is an important autoimmune GWAS locus!
YoshihikoTomofuji@YoshiTomofujiAug 5
We are excited to share our latest preprint on surface protein QTL mapping & experimental fine-mapping of the CD40 autoimmune locus in B cells w/ @soumya_boston @broadinstitute @MGBResearchNews! 🧬🧵👇 🔗 biorxiv.org/content/10.64898…

Identifying the causal allele in the CD40 autoimmune locus enables discovery of context-specific...

Thousands of genetic variants are associated with autoimmune diseases, but causal variants, their mechanisms, and the pathogenic context in which they act are elusive. Knowledge of pathogenic...

biorxiv.org
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Excited to see the final chapter of my PhD published. Huge thanks to my PhD advisor @yang_i_li, as well as @LB_Barreiro!!!
Cell Genomics@CellGenomics10 Nov 2025
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts dlvr.it/TPBCW0

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts

Mu et al. performed single-cell chromatin accessibility quantitative trait locus (caQTL) mapping in human peripheral blood mononuclear cells and found that caQTL explain roughly 50% more disease...

cell.com
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So excited to share our latest with Betty Diamond and many colleagues from the AMP RA/SLE consortium, @NIH_NIAMS , and @NIAIDNews ! A large-scale blood and tissue atlas of Lupus Nephritis! biorxiv.org/content/10.1101/…

A population-scale atlas of blood and tissue in lupus nephritis

Lupus nephritis (LN), a severe manifestation of Systemic lupus erythematosus (SLE), is a heterogeneous disease driven by diverse immune and tissue cell types. Current treatments of LN are non-speci...

biorxiv.org
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Zepeng (Phoenix) Mu retweeted
Yuriy Baglaenko@YuriyBaglaenko23 Jul 2025
I am very excited to share our publication, out now in Nature, detailing our developed CRAFTseq methodology for capturing and analysing single cell genomic DNA amplicons alongside the transcriptome and cell surface protein expression. nature.com/articles/s41586-0…
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Join me for this lecture to find out how we use genomics to decipher #autoimmunity and #rheumatoid arthritis
Broad Institute@broadinstitute16 Jul 2025
Join us on Thursday, August 14 at 6 PM ET in Cambridge, MA – or online – for a Broad Discovery Series talk with @soumya_boston: “Arthritis, autoimmunity, and how the genome works.” Register: broadinstitute.swoogo.com/Di… #ScienceTalks
talk poster

ALT talk poster

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Zepeng (Phoenix) Mu retweeted
Saori Sakaue@saorisakaue27 Feb 2025
📣Excited to share my last postdoc paper with @soumya_boston on eQTL mechanisms depending on where the RNA is in the cell! @BrighamResearch @broadinstitute TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵👇
bioRxiv Genomics@biorxiv_genomic26 Feb 2025
Early and late RNA eQTL are driven by different genetic mechanisms biorxiv.org/content/10.1101/… #biorxiv_genomic

Early and late RNA eQTL are driven by different genetic mechanisms

Understanding the genetic regulation of RNA abundance is essential to defining disease mechanisms. However, conventional expression quantitative loci (eQTL) studies quantify RNA molecules across the...

biorxiv.org
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Zepeng (Phoenix) Mu retweeted
Yoav Gilad@Y_Gilad17 Jan 2025
My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. It’s available on Amazon: tinyurl.com/mx2hewen
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Excited to share the final chapter my PhD research on @medrxivpreprint! eQTLs only explain 30% of GWAS loci and 11% of trait heritability. Here we investigate if epigenetic QTL can provide new insights at the remaining GWAS loci. medrxiv.org/content/10.1101/…

Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts

Only a third of immune-associated loci from genome-wide association studies (GWAS) colocalize with expression quantitative trait loci (eQTLs). To learn about causal genes and mechanisms at the...

medrxiv.org
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more replies
To conclude, we believe it is crucial to continue studying the genetic regulation of molecular phenotypes in more disease-relevant contexts. Furthermore, we emphasize the necessity of integrating various functional assays to elucidate causal mechanisms at GWAS loci.
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Huge thanks to my PhD advisor @yang_i_li and all collaborators especially @LB_Barreiro for their help and support!!! Huge thanks to all the donors! This data is a subset of a larger scRNA/scATAC data, read more about the cool discoveries in threads from @he_randolph!
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