AI in science and engineering @microsoft @mit @cern
NYC
Joined December 2019
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Felipe Oviedo retweeted
“In the early 1960s, when Draper was one of the few people offering early funding to tech startups on the West Coast, he frequently had to start his meetings with entrepreneurs by explaining what venture capital was.”
What a legend. RIP. No way these early practitioners could predict what VC could do in this world. But they blazed the trail.
Felipe Oviedo retweeted
Crime in New York City is a layered topic that confuses almost everybody, because it kind of alternates between right wing and left-wing talking points
Layer 1: NYC is actually really safe
Layer 2: …because they employ a lot of police and policing works
Layer 3: …which shows that multiculturalism can work
Layer 4: …at significant cost and Herculean effort
Felipe Oviedo retweeted
energy is local. stopping datacenter builds, as NY just did (rather than designing win-win requirements and incentives for local communities and builders) is going to lead to some geos having decrepit infrastructure, and some geos benefiting from grid upgrade, investment and economic revitalization.
the state needs to “plan” faster. the last time the bureaucracy said they’d study energy it led to a 30-year abject failure to build any (clean) nuclear capacity. a standard nuclear EIS takes 4 years to even get a decision
Felipe Oviedo retweeted
Happy birthday America!
There’s no place like you.
Thanks for *everything*
Love,
Refugee, 1983
Felipe Oviedo retweeted
Since two of these benchmarks are provided by us @Dyno_Tx , I can confidently comment.
- The AAV one is uncontaminated private data of a viral trait that we've been measuring for years (i.e. sharing publicly will defeat its purpose), and use it every day (required not sufficient) to design capsids that actually do work in primates. This performance provides a real lift in expertise and resources needed to do viral evolution.
- The black-box sequence design challenge is our take-home interview. Fable completely outperforms the best people in the field on given the same exact instructions as humans, again in a private task not seen on the internet. We will release this task publicly at some point.
Biology is slow. Real accomplishments take time because the bottlenecks downstream are meaningful.
But dismissing both the upside and the risk is highly premature. They've accomplished about as much as you could imagine. In particular, being wrong on the risk is extremely costly. I for one am the most excited I've ever been that bio is going to be transformed, and agentic reasoning is a big part of why.
Also the "unknown company" is actually very well known among experts because they are all very smart/accomplished people but are not hype-y on the twitter-verse.
Felipe Oviedo retweeted
we live in age of great moral panics about things that don’t matter and zero moral outrage over some of the most egregious societal sins we’ve ever seen
Felipe Oviedo retweeted
Artificial intelligences do not undergo experiences, do not possess a body, do not feel joy or pain, do not mature through relationships, and do not know from within what love, work, friendship or responsibility mean. Nor do they have a moral conscience, since they do not judge good and evil, grasp the ultimate meaning of situations, or bear responsibility for consequences. They may imitate or even simulate, but they do not understand what they produce, for they lack the affective, relational, and spiritual perspective through which human beings grow in wisdom. #MagnificaHumanitas
Felipe Oviedo retweeted
The biggest bullshit move by DHS in its history. So everyone on a O1 or H1B visa would have to stop working legally in the US, go back to their country and wait for years of backlog? This includes top scientists in our universities, founders of billion dollar companies (at least 3 just in our portfolio would be affected by the way). And if we look at individual countries it becomes even more bs. Indians would have to wait decades. Russians don’t have anywhere to go (there is no US embassy in Russia, hello?).
This is the worst imaginable way to disrupt important work for the country and pretend you’re fighting some loophole.
Felipe Oviedo retweeted
Zoning adds $300 - 500k to the price of a home in cities with good jobs. High-speed rail takes 30 years to build. New drugs cost $2B. We pay 5-10x what peer countries do for the same infrastructure.
People call this "regulation." It isn't, exactly. It's stranger and worse. 🧵
Felipe Oviedo retweeted
Countries get the cabinets they pay for. Singapore pays its Foreign Minister about S$1.1m, around US$800,000. The salary is benchmarked to 60% of the median income of the top 1,000 Singaporean earners. That is why you can get Vivian Balakrishnan, former eye surgeon and hospital chief executive, implementing @karpathy's external brain idea (link below). The speech shows deep understanding of AI and fills one with confidence about Singapore's future.
The UK Foreign Secretary earns roughly £165,000: the MP salary plus a ministerial salary of about £67,000. The ministerial part is frozen since the crisis and is down by roughly a third in real terms since 2010. This is what a junior Magic Circle lawyer earns.
Spain pays its ministers around €85,000. So you do not get a surgeon who has run hospitals. You get a party loyalist who has never run anything.
Felipe Oviedo retweeted
visual metaphor for the CTO transitioning into a member of technical staff and 50x’ing all the existing ICs with AI
Felipe Oviedo retweeted
Constantly crying about successful people is a losing position for leftist politicians. It’s un-American, and people aren’t dumb: they see blue cities deteriorate as taxes climb, companies leave, and businesses still deliver products that work. Only one side looks incompetent
Felipe Oviedo retweeted
Intelligence is a system level description of emergent coordinated action in response to the environment, and it does not require any 'embodied self'
Felipe Oviedo retweeted
For only $30m, we can have a high visibility demonstration of the failure of socialism.
Maybe this is a good idea after all.
Mayor Zohran Mamdani that the first city-owned grocery store – which carries a whopping $30 million expected price tag – won’t open until 2029. trib.al/zJEMm8D
Felipe Oviedo retweeted
nyc provides infinite optionality, which means you can perpetually avoid the commitments that force psychic maturation.
this is why when you speak to a 30yo in nyc it’ll almost always feel like you’re talking to a 20 year old.
this is primarily due to the fact that most ppl in nyc have never been forced to close doors. & closing doors is literally what growing up is.
Felipe Oviedo retweeted
In 2025, New York state permitted 37,885 homes. South Carolina permitted 45,564.
New York is almost 4× the size of South Carolina, but it built 20% less.
Median home price:
NY: $599k
SC: $376k
NY is one of the only states shrinking in population. It's a choice.
Felipe Oviedo retweeted
Catastrophic forgetting has long been a challenge in continual learning.
However, our new study found that pretrained Vision-Language-Action (VLA) models are surprisingly resistant to forgetting!
Zero forgetting, or even positive backward transfer, is possible with simple experience replay.
arxiv.org/abs/2603.03818
