@calebrperez

PhD Student | Birnbaum Lab | CAR T Cell Librarian @MITdeptofBE @KochInstitute

 Cambridge, MA
Joined September 2014
  • Tweets29
  • Following130
  • Followers136
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Excited to share some of my PhD work was pre-printed! Using single-cell sequencing, we took a deep look at a library of CAR signaling architectures to try to identify signal-intrinsic drivers of CAR-T function🧵👇 @MEBirnbaum @kochinstitute @MITdeptofBE biorxiv.org/content/10.1101/…

Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence

The anti-tumor function of engineered T cells expressing chimeric antigen receptors (CARs) is dependent on signals transduced through intracellular signaling domains (ICDs). Different ICDs are known...

biorxiv.org
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Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells biorxiv.org/cgi/content/shor… #biorxiv_immuno
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Caleb Perez retweeted
TwoStepTx@TwoStepTx25 Jun 2024
1/ We’re excited to announce our official launch and the closing of a $6.5M seed round to advance our pipeline of targeted therapies for solid tumors. Learn more 👉 businesswire.com/news/home/2…
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.@MEbirnbaum has been chosen to receive this year’s Bose Award for Excellence in Teaching. This award celebrates a faculty member who exemplifies exceptional dedication, care, and creativity in undergraduate education.
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An incredibly impressive body of work from the newly-minted PhD @calebrperez comparing clinical candidate CAR-T architectures head-to-head at single cell resolution, shedding light on mechanisms of differential CAR-T efficacy in vivo with insights into better construct design 🚗
Caleb Perez@calebrperez3 May 2024
Excited to share some of my PhD work was pre-printed! Using single-cell sequencing, we took a deep look at a library of CAR signaling architectures to try to identify signal-intrinsic drivers of CAR-T function🧵👇 @MEBirnbaum @kochinstitute @MITdeptofBE biorxiv.org/content/10.1101/…

Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence

The anti-tumor function of engineered T cells expressing chimeric antigen receptors (CARs) is dependent on signals transduced through intracellular signaling domains (ICDs). Different ICDs are known...

biorxiv.org
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The lab will have to ask these questions without me though, as I'm defending in two weeks! DM me for details if you want to hear more about my projects, or better yet, if you’ve got a job opening 🙏🙏🙏
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And lastly, thanks so much to everyone who helped in this work! @agarmilla98, Avlant, @hmbaghdassarian, Louise, Khloe, @_blake_smith, you were all integral to the paper, so thank you so much! And @MarcelaMaus, Doug, and @MEBirnbaum, I’ll always appreciate your advice and support!
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"It is my great pleasure to announce that Professor @MEBirnbaum has been promoted to Associate Professor With Tenure. He is making outstanding contributions to BE, MIT and our field with his scholarship, teaching, mentoring and service." BE Dept Head Angela Belcher
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