
Consultant Clinical Oncologist. #NHS Campaigner. Steering committee @SABRconsortium & @BTOGorg. Views personal #radonc https://xitter.cf/t.co/z25yqk0ERH
North Yorkshire
Joined September 2011
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Harry #Kane deserved winner of Ballon D’Or. He has redefined the role of a modern striker with high numbers of assists as well as goals, world class passing and vision, and defending at crucial times. Not as skillful as Yamal and Mbappé, but all round game better.
5. SARON: synchronous oligometastatic, actionable-genomic-alteration–negative NSCLC, adding LCT to systemic therapy. RT improved median PFS - 13.9m Vs 8.9m. *No OS benefit*, but no extra serious side effects. Consider LCT in fitter patients with lower metastatic burden #ESMO26
Honorable mentions:
OptiTROP-Lung04 (sacituzumab tirumotecan) and PANKU-Lung01 (izalontamab brengitecan) could change post-EGFR-TKI treatment sequencing.
SANOVO (savolitinib) could move MET-directed therapy into the first-line setting. #ESMO26
Clive Peedell retweeted
New standard of care for KRAS G12C mutation positive NSCLC. @FSkoulidis presents Krascendo-1 head to head trial of divarasib vs sotorasib or adagrasib- convincing improving PFS (9.8 m vs 5.7 m, HR 0.58) and OS (17.7m vs 12.0m, HR 0.58)
Clive Peedell retweeted
#ESMO26 Dr. Yilong Wu @ThomasW35874311 presents SANOVO: 1L osimertinib + savolitinib/placebo in EGFR+ NSCLC with MET overexpression. Wow. PFS 24.8 vs 11.1m, HR 0.45 with OS 44.5 vs 34.9m, HR 0.48. RR 81% vs 68%. Toxicities below. Very impressive. #ESMOAmbassadors
Clive Peedell retweeted
#ESMO26 PROTEUS discussion by Nicholas van As
• No baseline PSMA PET; enrolled conventionally staged M0
• MFS events: true progression or delayed detection? Most were PSMA PET-detected (8.8% vs 16.3%)
• TTST HR 0.29, but ~20-mo lead-time bias
#ProstateCancer
#Norway’s Sovereign wealth fund is the dagger to the heart of Thatcherism. She sold off the family silver for a short term boom. Now we are suffering a long-term bust. nbim.no/en/
Clive Peedell retweeted
Replying to @Jeremy_Hunt
2004 wasn’t the time Family Doctors were scrapped
2010 seems to be the moment the decline started
@Jeremy_Hunt you failed because you didn’t invest in GPs
Funding was cut 2014-2024 by 20% per patient, training more but no funding to retain
Then there was funding of ARRS 🤷🏻♂️
Clive Peedell retweeted
NEW
Britain’s missing sovereign wealth fund… Treasury officials have modelled that had the UK done what Norway did with North Sea revenues, there would be a £1 trillion fund…
As Chancellor sets up Energy Wealth Fund, a look at the long historical argument about where the oil windfall went, including from interviews with those who have run Norways $2.4 trillion fund, now the biggest in the world, filled from the proceeds of the same North Sea.
bbc.co.uk/news/articles/cm4g…
Clive Peedell retweeted
I have read dozens of outraged posts because the US special envoy Witkoff called Putin a "humanist." But no one is writing about the fact that the American negotiators are simply not doing their job. Let me explain.
Peace negotiations are important in their own right. Even if they do not lead to a lasting peace, the process itself is an opportunity to resolve urgent humanitarian issues. If, of course, the human dimension is a priority for the negotiators. But it is entirely obvious that neither Witkoff nor Kushner cares about people's fates in this war.
The Pope calls on Putin to save thousands of people from starvation in occupied Oleshky and the surrounding villages. The UN speaks about a humanitarian catastrophe and asks Russia to allow the evacuation of the civilian population. European Parliament Vice-President Pina Picierno goes on a hunger strike to draw attention to this tragedy unfolding before the eyes of the whole world.
And what are Witkoff and Kushner doing?
That's right, almost nothing.
Except for passing along greetings from Putin’s aide to the First Lady.
Thousands of people are already eating grass to survive and begging to save their lives. The Ukrainian side raises the issue of Oleshky at every meeting. And I can name dozens of such urgent humanitarian issues off the top of my head where American negotiators must be proactive.
Trump’s peace negotiations have already gone down in history as the deadliest years for Ukraine’s civilian population since the start of the full-scale invasion.
I don’t know if anyone will remember the names of Witkoff and Kushner.
But history will certainly record how American negotiators, who had the opportunity to save a huge number of people, refused to raise uncomfortable questions before "humanist Putin."
Clive Peedell retweeted
Trump’s envoy to Putin. One of the most sickening things I’ve ever seen. Future generations will scarcely believe America fell this low, if it ever recovers.
Here’s the British take on Trump, Russia and press secretaries @gtconway3d
































