Physician Scientist @HarvardPulm @MGHmedicine | @jkagan1 and @RMedzhitov alum
Boston, MA
Joined March 2007
- Tweets468
- Following438
- Followers355
- Likes805
Dan Okin retweeted
A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the summary below for all we learned.
cell.com/immunity/fulltext/S…
Dan Okin retweeted
We are thrilled to announce an opening for a tenure-track assistant professor in PCMM, Boston Children's Hospital and Harvard Immunology! Apply by August 2, 2026.
Dan Okin retweeted
Who wants to discuss innate immunity and host defense?
Join us in Banff to share your exciting research.
keystonesymposia.org/confere…
Dan Okin retweeted
Application now open: Career Awards for Medical Scientists (CAMS) is a highly competitive program that provides $700,000 awards over 5 years for physician-scientists, who are committed to an academic career
Deadline: 10/07/25
buff.ly/VdljzxQ
#bwfcams
Check out this must read from @Lo_Zanzi and @dfrboehmer on IFNs👇🏻
#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 authors.elsevier.com/a/1leKG…
👇🏻👇🏻👇🏻Check out this great study on oxidized lipids and how they control inflammation!! Congrats @Lo_Zanzi !
#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10! authors.elsevier.com/a/1lS0g…
Congrats @XuZhouLab on a fantastic study, excited to see where you take this next!
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/arti…
Dan Okin retweeted
BRD4 acts as a pH sensor to tune inflammation bit.ly/3IOIyNU
Dan Okin retweeted
Finally, our study on caspase-11 and its CARD-recognized molecular pattern is out in Science Advances! A small step, but we hope it opens new directions for studying caspase-11 and its ligands. 🔬🚀 #Immunology #Caspase11 #ScienceAdvances
🔗 science.org/doi/10.1126/scia…
Congrats on the great story @JelenaLab!!
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer science.org/doi/10.1126/scia…
Dan Okin retweeted
We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should come!
Dan Okin retweeted
The more I think about it, the more I think 2013-era morality is pretty much correct:
* free speech good
* starting companies and making good products good
* monopolies bad, vendor lock-in bad
* democracy good
* greed bad
* trying to achieve national security through oppressing people bad
* cosmopolitan humanitarian values, caring about faraway people, etc good
Things we've "learned" since then have been harmful more than helpful
Dan Okin retweeted
I need people to understand how difficult it is to get an NIH grant. You spend months writing a proposal, following strict guidelines that include a detailed multiyear budget, bios of everyone on your team, plans for participant safety & ethical conduct. Then you send it off -1/n
Congrats @Dr_KatieM and team at @DanaFarber on the wonderful work published in @SciImmunology today science.org/doi/10.1126/scii…
Dan Okin retweeted
In a study published in @SciImmunology, led by @Dr_KatieM, @DanaFarber researchers have identified key factors that contribute to the success of donor lymphocyte infusion to treat relapse of acute myeloid leukemia after stem cell transplant.
Read more: bit.ly/4hurQQg
Wonderful piece @vcunningham and congrats on the new kid! Merry Christmas! 🎄
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Dan Okin retweeted
1/ Introducing SCimilarity, a new foundation model to explore scRNAseq data across tissues and diseases! It learns a common measure of cell similarity by training a deep metric learning model on millions of cells from various human tissues and conditions. nature.com/articles/s41586-0…
Dan Okin retweeted
The recorded video of Dr. Jon Kagan seminar entitled Regulation of Innate Immunity is now available at “Global Immunotalks” YouTube Channel youtu.be/nrgrK0SMqDU
Hope you enjoy it!
#globalimmuno #immunology
Dan Okin retweeted
#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper @CellCellPress with @achillebro! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OA…
Dan Okin retweeted
Thrilled to share our findings on NINJ1 autoinhibition, now online in @Nature. Big thanks to the amazing team @dixitvishva @Melissa_Truong @DrMCJohnson @AlexisRohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)