Staff scientist @UCSF. Formerly @UCBerkeley, @HHMINEWS.
San Francisco
Joined May 2011
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Daniel Sirkis retweeted
Five years ago we sketched out the designs for our first epigenome editors. Proud to see those sketches move into the clinic.
You can read more about the technology underpinning our epi-editors in this preprint we recently presented at ASGCT: biorxiv.org/content/10.64898…
Announcing our first clinical trial.
Scribe has secured regulatory clearance from Australia’s @TGAgovau to initiate a first-in-human clinical study of STX-1150 for the treatment of hypercholesterolemia, a major driver of atherosclerotic cardiovascular disease (ASCVD).
Details🧵
This story sounds awesome, but I am a bit confused by your ROSMAP findings summarized in Table 1. Do I understand correctly that no HSV-1 reads were detected in *any* of the 427 donors? My understanding is that only ~56% of these donors had a path Dx of AD, ... (1 of 2)
A history of viral encephalitis is one of the strongest risk factors for developing dementia. With @JacobJacobog02, Yifan Chen, @RNA_Life, and @RyanDhindsa, we refine this link by describing a neuronal cell type that can reactivate HSV-1 in humans 1/n
biorxiv.org/content/10.64898…
ALT https://www.biorxiv.org/content/10.64898/2026.04.29.721769v1
Daniel Sirkis retweeted
Transforming traditional views laid by “CNS immune privilege,” our research uncovers the brain’s purposeful presentation of self – that is the brain engages with the immune system through “guardian” peptides to ensure immune tolerance. @jonykipnis
nature.com/articles/s41586-0…
Daniel Sirkis retweeted
Check out our new preprint showing our ability to use epigenetic age measured from blood to predict AD progression & cortical atrophy! @dwsir @UCSFimaging @UCSFmac @nanosanta @AgustinMIbanez @Cornell researchsquare.com/article/r…
Daniel Sirkis retweeted
New paper out📢! Toxic effects of IFN-I in humans has been suggested in patients with rare monogenic autoinflammatory diseases (SAVI, CANDLE, AGS) where IFN-I are elevated. In the absence of specific inhibitors, their causal role has been difficult to prove. We now report benefit of specific anti-IFNAR1 (#Anifrolumab) in 5 patients verifying the causal role of IFN-I in these diseases: rdcu.be/dXWPw
ALT https://doi.org/10.1126/sciimmunol.adm8185
Holy moly. In some individuals, p-tau181 is >300-fold higher in cervical lymph nodes than plasma. Seems like this could be a reasonable location to predict exposure of T cells to tau-derived peptides.
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Having worked on mechanisms of unconventional synuclein secretion, this paper looks awesome and the data compelling. However--not having read the full text--I am left with the following dispiriting impression:
- Arc function = bad outcome
- lack of Arc function = bad outcome
At the end of 2018 I was lucky to receive a @cziscience Ben Barres award. This preprint is the culmination of that funding, which allowed us to try "out of the box" ideas to study neurodegeneration. Fearlessly led by amazing student @MitaliTyagi2! 🧵 /1 biorxiv.org/content/10.1101/…
Daniel Sirkis retweeted
For the first time in 114 years, biologists from the Oregon Department of Fish and Wildlife have observed a fall-run Chinook salmon returning to spawn in the Klamath Basin in Oregon, after dam removal.
Daniel Sirkis retweeted
Circulatory proteins shape microglia state and boost phagocytosis!!!!! biorxiv.org/content/10.1101/…
Daniel Sirkis retweeted
Continuing with #crossreactivity and #TCR Another paper that I #love We simply #cant #afford to have "#holes" in the #repertoire. Virus-Specific CD4 Memory-Phenotype T Cells Are Abundant in Unexposed... sciencedirect.com/science/ar…
I enjoyed leading this effort to highlight recent advances in understanding interferon pathway dysregulation in neurodegenerative disease, including new work by our group. We also discuss cognitive and behavioral changes related to IFN and its relevance in psychiatric disease.
Learn about the intriguing connections between neurodegenerative & neuropsychiatric diseases 🪢 via alterations in interferon signaling! 🧠
@dwsir @AlexisOddi @C_WSolsberg @UCSFmac @DataTecnica @FTDcwow @GBHI_Fellows #WomenInSTEM
frontiersin.org/journals/psy…
Daniel Sirkis retweeted
Learn about the intriguing connections between neurodegenerative & neuropsychiatric diseases 🪢 via alterations in interferon signaling! 🧠
@dwsir @AlexisOddi @C_WSolsberg @UCSFmac @DataTecnica @FTDcwow @GBHI_Fellows #WomenInSTEM
frontiersin.org/journals/psy…
I learned something new today!
Time and time again, I remind myself this #figure and #paper ...an essential #read for #TCR ->A very high level of crossreactivity is an essential feature of the T-... sciencedirect.com/science/ar…
Daniel Sirkis retweeted
HHMI Investigator Zhijian "James" Chen of @UTSWMedCenter has been named the 2024 Albert Lasker Basic Medical Research Award winner for his discovery of the DNA-sensing cGAS enzyme, which triggers immune & inflammatory responses. 👏
👉 hhmi.news/47wJnn2
Daniel Sirkis retweeted
A neurologist in Colombia, he worked with the world’s largest extended family with Alzheimer’s and helped fuel research to prevent or delay dementia symptoms. nyti.ms/3MGKozi
Daniel Sirkis retweeted
Incredibly excited to share our latest work exploring the antigen specificity of clonally-expanded CSF-enriched CD8+ T cells in MS #multiplesclerosis #Tcells #EBV 🧵1/
biorxiv.org/content/10.1101/…
Daniel Sirkis retweeted
Immortal quote from the amazing geneticist Gerry Fink…
“Just because it’s in Nature…
… doesn’t necessarily mean it’s wrong!”
Daniel Sirkis retweeted
We report many proteins not predicted by the genetic code.
They are stable & abundant O( 10³ ) copies / cell.
Generative mechanisms include codon-anticodon mismatches & RNA modifications.
Their abundance depends on codon frequency & protein stability.
biorxiv.org/content/10.1101/…
Daniel Sirkis retweeted
🚀 Excited for @YokoyamaLabUCSF to serve as Editor-in-Chief for @Nature_NPJ! #DementiaResearch #OpenAccess #cwowleads