Haematologist by day, immunologist by night. I study how immune niches in the tissue regulate T cell function. PhD @powrie_lab, postdoc @teichlab
Cambridge Stem Cell Institute
Joined January 2018
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So happy to share my PhD work published today @Nature ! We studied how tissue niches shape Treg function. So grateful to Fiona @powrie_lab, Emily @emilyethornton and a wonderful collaboration with Sarah @teichlab and Raquel @RBartolom. We did it! nature.com/articles/s41586-0…
Yisu Gu retweeted
1. CRISPR came from basic research on bacteria.
2. Optogenetics started with a discovery in algae.
3. The GFP protein comes from jellyfish.
The biggest breakthroughs all trace to scientists follow their curiosity. This is one huge reason why we must keep funding basic research!
Yisu Gu retweeted
Thanks for a great writeup (and fun photo session) from @pitt_immunology on our latest work in @Nature describing how a meal can improve T cell metabolism and function!
Feed your T cells! A new @Nature paper from @DelgoffeLab shows that T cells collected after a meal are more potent than those from fasted individuals, suggesting potential for diet-based strategies to improve cancer immunotherapy & vaccine responses.
immunology.pitt.edu/news/eat…
ALT Greg Delgoffe and Alok Kumar sit at a table, each taking a big bite of a sandwich.
Yisu Gu retweeted
🚨Only 1 week left to apply🚨 3-year Postdoc Position on Spatial Biology & Bioinformatics in my lab👇:
🚨 3-year Postdoc Position @HallouLab (Kennedy Institute, Oxford) - on Spatial Biology & Bioinformatics of Fibrosis🚨
Exciting project combining #SpatialTranscriptomics & #Mechanobiology:
shorturl.at/LLS5r
Deadline: 16 March - Please RT 📢!
@KirOxford @UniofOxford
Yisu Gu retweeted
Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab
👉Key takeaways:
1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted.
2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease.
Thanks our incredible collaborators @niroanandalab @EmmaGuttman @kamalkhanna @Teresalu @Amandalund and others. Our funders @NIAIDNews @NIH @DermalCell @SinaiImmunol @MSHSDerm
nature.com/articles/s41586-0…
Yisu Gu retweeted
Thrilled to share latest work: Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - now online in Nature Immunology. @alberto_g_conti, Alex Evans, @teresavlinde, @IanParish_AU, @cdtdeg @CRUKCamCentre
nature.com/articles/s41590-0…
Yisu Gu retweeted
Contextualizing TH17 cells in cancer bit.ly/4qDA2C7
Yisu Gu retweeted
Decoding Peripheral Tolerance: TCR Rules for pTreg differentiation in the Gut @biorxivpreprint
biorxiv.org/content/10.1101/… @harvardmed 🇺🇸
Inspired by yesterday’s Nobel Prize announcement? Then apply for a PhD with @teichlab @SCICambridge to study how peripheral immune tolerance is maintained using models including graft versus host disease. Clue: Tregs are a key player! More details here: stemcells.cam.ac.uk/phd-proj…
Yisu Gu retweeted
Immunology takes center stage again at the #NobelPrize! Congratulations to Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi for uncovering how regulatory T cells maintain immune tolerance—a discovery that transformed our understanding of autoimmunity and cancer immunotherapy
Yisu Gu retweeted
NEW: Research shows that tumours aren’t just shaped by genetics - their physical surroundings matter too.
When cancer cells feel 'squeezed' by nearby tissue, they can switch gears: instead of growing fast, they spread more easily and become harder to treat.
Read more ⬇️
ALT Graphic illustration of cancer cells on a blue background with the text 'Pressure flips the switch on cancer cells' and the University of Oxford logo and website link at the bottom.
Yisu Gu retweeted
First time visiting @Cambridge_Uni and the Cambridge Stem Cell Institute! Excited to meet @TzelepisLab and several other friends and colleagues!
Yisu Gu retweeted
Huge news! A £50M MRC CoRE will bring together Manchester & Oxford to study how environmental exposures cause chronic inflammatory disease.
It will be Directed by Prof Judi Allen (Manchester) & co-Directed by Prof Dame Fiona Powrie, Director of the KIR.
kennedy.ox.ac.uk/news/new-ps…
Yisu Gu retweeted
IMMOX'25 - Genetic Variation and Barrier Immunity, Oxford, March 17th - 19th 2025.
Meet our esteemed KEYNOTE SPEAKERS @IdoAmitLab Noah Palm @YaleMed
Speaker lineup, abstract submission, registration:
bit.ly/immox25
#IMMOX25 #barrierimmunity #immuneregulation #Tcells
Yisu Gu retweeted
Endogenous CNS-derived regulatory self-peptides presented on MHCII molecules during homeostasis (drops in neuroinflammation) drives Treg expansion that reinforce immune privilege of CNS @Nature @jonykipnis @mitchkim_mw
nature.com/articles/s41586-0…
Guardians of the brain galaxy: Endogenous self-peptides guard immune privilege of the central nervous system @Nature nature.com/articles/s41586-0…
Yisu Gu retweeted
Transcription factor TCF1 binds to RORγt and orchestrates a regulatory network that determines homeostatic Th17 cell state @ImmunityCP @AnaAndersonlab @Dr_ImmunoMan_D
cell.com/immunity/fulltext/S…
Please consider applying for a PhD with the Powrie lab - you won’t regret it! You will receive world- class training in immunology and there is something for all interests: basic and translational 👍
Yisu Gu retweeted
Sir Ravinder Maini FMedSci FRS and Professor Sir Marc Feldmann AC FMedSci FRS are jointly awarded the Royal Medal 2024 for inventing anti-TNF therapy to treat rheumatoid arthritis, bringing their therapeutic from bench to bedside in one of the biggest success stories in modern medicine, and laying the groundwork for biologics to improve the quality of life for millions of people. #RSMedals
royalsociety.org/medals-and-…
Picture credit: The Lasker Foundation
