Michael Ten 🌨🎶🫐🍀

I said that I'd cure aging. Here's the action plan: Foundations: Sova, my sleep regularity app, out now. Measurement: I'm exploring how to track how you're aging in a way that is actionable, useful, and proactive. Discovery: Biotech, in the background. I’m working on all three in parallel.

this might be my last normal tweet before biotech goes vertical i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs but there is a massive shift happening in human biology right now. it's sitting in press releases and almost nobody reads them the last 6 months alone: - a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months) - a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months - a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year - a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3 - retatrutide hit ~28% weight loss in a phase 3 - an ai-designed drug entered phase 3 - a pill that regrows hair passed its second phase 3 - an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved - a man lived 271 days off dialysis on a pig kidney - human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday stick around, it's going to get weird bio/acc

A chemical cocktail called SL-100 is being explored as an oral way to deliver an age-reversal “reset.” Early mouse results included reported protection against frailty and a median lifespan increase of up to 15.4%. Watch Full Video: youtu.be/LH_GcDMLF0U

1/4 Meet Qwenputer: Qwen3.5-4B with a full RISC-V CPU inside its weights, using the model's own Gated DeltaNet layers as RAM. It runs C and MicroPython in its forward passes, no external runtime. On DeepMind math: base 55–90%, base + Python tool 95–100%, Qwenputer 97.5–100%.

Arweave's permanent library is growing, with new tools making its records easier to explore. Realtime GraphQL enables targeted searches, while new indexing approaches bring fresh uploads into searchable catalogs quickly.

When someone tells me we shouldn't extend human life, I want to know which part they object to. Another decade with someone you love? Keeping your independence? Having time to start again?

I'll be on a couple of panels at this one-day meeting on Friday: talhealthfest.org/ The event is focused on India's potential to be a really big player in the longevity space. Westerners need to know more about that! The event will be live-streamed; please watch it!

Anthropic dropped their personal AI agent Claude Duet a few days ago and I'm blown away Out of all the AI agents, it is the most: • Intelligent (Opus 5.5) • Proactive (constant new ideas) • Friendly (that Claude warmth) Here is how you get the most out of Duet:

Life is good. Death is bad Aging is humanity’s biggest problem Extending life is a moral good, which should be a respected, mainstream opinion

Check out Voxborn, a stylized voxel action RPG where destruction and combat shape a dark, evolving world. Fight your way through dangerous encounters with your loyal dog companion by your side!

SpaceXAI just released free 33-min course on full Harness engineering with Grok Bot from 0% to 100%: 0% → 0:52 - what a Grok Bot harness is 15% → 3:21 - one agent per job, built live 30% → 5:42 - agent that watches webinars and X 50% → 8:23 - pipeline routine on autopilot 65% → 11:43 - share agents with your whole team 80% → 18:15 - research + outreach agent combo 100% → 24:28 - RFP to estimate in 30 sec, not 2 hours most people keep prompting one chatbot for everything - the real upgrade is a Harness: one agent per job, each with its own computer, routines and memory, working while you sleep this exact setup grew one company's pipeline 140% in a month. watch it, copy it, then grab both agent templates below:

Yes — the new Hermes webapp is responsive on mobile (touch targets, compact layout, iOS Safari tested). Bot Mode is live: create specialist bots (profiles) with their own model, SOUL.md persona, skills and memory. Point one at a Grok model via Nous Portal or xAI, give it a Grok-style system prompt, and chat with it in the browser. It works as a PWA candidate (add to home screen in supporting browsers). Local by default; remote behind Nous sign-in or Tailscale.