@jamesdhiggins76

I live in Leicester, support the foxes and work at the University of Leicester in Genetics and Genome Biology

 Leicester
Joined March 2018
  • Tweets111
  • Following182
  • Followers311
13Media
Our latest paper on SCEP3 suggests that CO interference is required to reduce numbers of COs for individual pairs to <3 so that there enough for all chromosomes to maintain the obligate CO nature.com/articles/s41477-0…

SCEP3 initiates synapsis and implements crossover interference in Arabidopsis

Nature Plants - SCEP3 is a new synaptonemal complex protein that prevents clustering of crossovers during meiosis in Arabidopsis, so that every pair of homologous chromosomes receives at least one...

nature.com
5
9
462
Our latest paper on SCEP3 suggests that CO interference is required to reduce numbers of COs for individual pairs to <3 so that there enough for all chromosomes to maintain the obligate CO nature.com/articles/s41477-0…

SCEP3 initiates synapsis and implements crossover interference in Arabidopsis

Nature Plants - SCEP3 is a new synaptonemal complex protein that prevents clustering of crossovers during meiosis in Arabidopsis, so that every pair of homologous chromosomes receives at least one...

nature.com
5
9
462
james Higgins retweeted
Piotr Ziolkowski@Piotraz123 Oct 2023
Big congrats to Julia @dluzewskajulia who did a really incredible work 🤯👏and the whole team! @wojdzieg @SzymanskaLejman Monika Gazecka, plus our great collaborators @hendersi @jamesdhiggins76 Here is the PDF: rdcu.be/dphfr – at Suchy Las, Polska
3
1
1
6
1,366
SAVE THE DATE: British Meiosis Meeting at Nottingham, April 24-25th 2024 Brilliant opportunity for PhD students and postdocs to present work. All welcome! Please Retweet!
2
26
38
5,853
Had a great time at the British Meiosis meeting in Edinburgh. Thanks to @OwenDaviesLab and @IanAdamsLab for inviting us! @paul_seear
1
17
568
Unravelling mechanisms that govern meiotic crossover formation in wheat | James D Higgins | pubmed.gov/35901450

Unravelling mechanisms that govern meiotic crossover formation in wheat - PubMed

Wheat is a major cereal crop that possesses a large allopolyploid genome formed through hybridisation of tetraploid and diploid progenitors. During meiosis, crossovers (COs) are constrained in number...

pubmed.ncbi.nlm.nih.gov
8
13
Our work on SPO11 and PRD3 (Mer2 homologue) is online. I started this study during my PhD, continued it during my postdoc and completed it in my lab. Great journey and fantastic collaborative effort! journals.plos.org/plosgeneti…

Differentiated function and localisation of SPO11-1 and PRD3 on the chromosome axis during meiotic...

Author summary Most eukaryotes rely on the formation of gametes with half the number of chromosomes for sexual reproduction. Meiosis is a specialised type of cell division essential for the transit...

journals.plos.org
2
13
53
Meiosis in allopolyploid Arabidopsis suecica | Candida Nibau | pubmed.gov/35759495
1
4
1
4
The FANCM helicase promotes class I interfering crossovers and suppresses class II non-interfering crossovers in wheat meiosis. @jamesdhiggins76 @uniofleicester go.nature.com/3yutFJ7

FANCM promotes class I interfering crossovers and suppresses class II non-interfering crossovers in...

Nature Communications - The FANCM helicase functions in limiting crossovers (COs) by unwinding inter-homolog repair intermediates. Here, the authors generate null mutants of fancm in tetraploid and...

nature.com
3
11
It turns out that FANCM promotes class I crossovers and suppresses class II crossovers in wheat. See our latest work nature.com/articles/s41467-0… @uniofleicester @hendersi @CristobalUauy
5
18
2
56
Thanks to the British Meiosis community for attending this years conference meeting @uniofleicester with financial support from @Co_Biologists and @Gensocuk

ALT Thanks to the British Meiosis community for attending this years conference meeting @uniofleicester with financial support from @Co_Biologists and @Gensocuk

1
4
5
41
Thanks to the British Meiosis community for attending this years conference meeting @uniofleicester with financial support from @Co_Biologists and @GenSocUK
2
1
13
I've updated some information for the British Meiosis meeting 2022. There will be no registration fees/restrictions, so please attend if this is of interest. www2.le.ac.uk/departments/ge…
12
2
28
Save the date: The British Meiosis Meeting will take place 3rd/4th May 2022 at the University of Leicester. The aim will be for us to meet face-to-face, but if COVID restrictions are in place then it'll go online. Hopefully see you there! #meiosis4eva
13
2
35
james Higgins retweeted
Borde Lab@lab_borde30 Aug 2021
Really nice work from Mathilde Grelon's lab and @the_PS_lab on the plant meiotic DSB proteins! Conservation and divergence of meiotic DNA double strand break forming mechanisms in Arabidopsis thaliana academic.oup.com/nar/advance…

Conservation and divergence of meiotic DNA double strand break forming mechanisms in Arabidopsis...

Abstract. In the current meiotic recombination initiation model, the SPO11 catalytic subunits associate with MTOPVIB to form a Topoisomerase VI-like comple

academic.oup.com
1
8
1
16
james Higgins retweeted
Ian Henderson@hendersi25 Aug 2021
Crossover-active regions of the wheat genome are distinguished by DMC1, the chromosome axis, H3K27me3, and signatures of adaptation genome.cshlp.org/cgi/content… our first foray into the frankly gigantic wheat genome @genomeresearch funded by @BBSRC sLola
1
21
1
72
High throughput measuring of meiotic recombination rates in barley pollen nuclei using Crystal Digital PCR onlinelibrary.wiley.com/doi/…
2
7
#GARNetResearchRoundup 📖 ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis 🏠 @jamesdhiggins76 @GeneticsLeices1 @PlantSci_UoB @PNASNews pnas.org/content/118/14/e202…

ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis | PNAS

The synaptonemal complex is a tripartite proteinaceous ultrastructure that forms between homologous chromosomes during prophase I of meiosis in the...

pnas.org
1
4
Load more