In the process of learning/

New York City
Joined August 2017
Karin(a) Isaev retweeted
Incredibly excited to highlight Omnii Genome, one of the eight applications of Omnii-1 Omnii Genome fuses 28 multiomic modalities natively across biology Against comparable benchmarks vs. AlphaGenome, it outperforms on all Omnii Genome is also *generative*, which means it can also be prompted any modality or cell state, and infer missing modalities e.g., prompt on desired gene expression, methylation pattern, and then generate the required DNA, or transcription factor pattern We believe this is going to accelerate so many new possibilities in life science, from multiomic target discovery, diagnostics, and gene therapy
1/10 Introducing Omnii Genome, one of eight Advances built on Omnii-1. A single generalist model now outperforms leading specialized models (AlphaGenome) in linking genetic changes to gene activity and mapping regulatory interactions. These capabilities help make sense of the 98% of the human genome that doesn’t code for proteins How Omnii-1 works:
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1/10 Introducing Omnii Genome, one of eight Advances built on Omnii-1. A single generalist model now outperforms leading specialized models (AlphaGenome) in linking genetic changes to gene activity and mapping regulatory interactions. These capabilities help make sense of the 98% of the human genome that doesn’t code for proteins How Omnii-1 works:
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came back on twitter/X to be able to share this amazing progress that the team has made! so proud to be a part of it. AIxBio is a bit of a loaded buzzword these days but I hope you will appreciate our real world applications and our general aim to balance innovation and safety!
Introducing Omnii-1, our most powerful genome language model, and a major step toward general biological intelligence In a world first, Omnii-1 designed the first AI-generated bacteriophages to be administered to a human patient with an antibiotic-resistant infection under compassionate use
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Karin(a) Isaev retweeted
Introducing Omnii-1, our most powerful genome language model, and a major step toward general biological intelligence In a world first, Omnii-1 designed the first AI-generated bacteriophages to be administered to a human patient with an antibiotic-resistant infection under compassionate use
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Karin(a) Isaev retweeted
1/ Excited to share our latest work: “Splicing up your predictions with RNA contrastive learning” 🎉 in which we present a new self-supervised learning objective for mature RNA 📄[Paper](arxiv.org/abs/2310.08738) 🛠️[Code](github.com/phil-fradkin/cont…) 🌐[Blog](portal.valencelabs.com/blogs…)
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Flaco the Eurasian Eagle-Owl looking smart and confident in his oak tree Tuesday evening in Central Park. 🦉 ♥️
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Karin(a) Isaev retweeted
1/ A week ago, the team at Deep Genomics released their RNA foundation model, BigRNA. Here are my thoughts on their great work! 🧬🔍 📄 Paper: biorxiv.org/content/10.1101/… 📝 Blogpost: deepgenomics.com/news/most-a…
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Karin(a) Isaev retweeted
I’m delighted that our paper on the Multicellularity Long Term Evolution Experiment (MuLTEE) has, at long last, been published. This paper establishes the foundations of what I’d like to work on for the rest of my career. 1/25 Free, full access link: rdcu.be/dbPA9
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Karin(a) Isaev retweeted
Fascinating new preprint on bioRxiv tackles a whale of a question: Whales are huge. So why don’t they get a ton of cancers? biorxiv.org/content/10.1101/…
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C.Origami, a machine learning model for cell type-specific chromatin architecture prediction and discovery of putative regulatory elements! Developed by our student @tan_jimin in collaboration with @BoXia7. @NatureBiotech @4DNucleome @EpigenChromatin @epigen_papers
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening go.nature.com/3GR6nRX
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Dormant endogeneous retroviruses awaken with and contribute to aging. Repression appears to alleviate cellular senescence cell.com/cell/fulltext/S0092… @CellCellPress
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when your sim card gets hacked on Christmas 😵 (lost access to my whataspp account). Make sure your voicemail has a pin!
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Karin(a) Isaev retweeted
Northern Sunset 48x48 acrylic on canvas
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Find me on post.news/karinisaev Excited to see if post.news/ ends up expanding, the interface is super nice just needs more users!
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Yesterday, I was happy to welcome one of my former labmate and friend, @karini925 , to the Crick. A great day to catch up on science and other things! ☀️
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Inaugural post-#ASHG22 lab (plus @EinsonJ!) hike was a resounding success!
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And last but not least @karini925 has a platform talk Friday 4.30pm "High-throughput assessment of isoform-specific function by targeting exon-exon junctions in a CRISPR/Cas13 forward screen" in the "Splicing together the story" session!
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This mind-blowing research in @Nature shows that machine learning can effectively guide enzyme optimization and help create enzymes that degrade all kinds of plastic waste in record time 🤯nature.com/articles/s41586-0…
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Karin(a) Isaev retweeted
Senior postdocs and fellows working in the broad area of computational and systems biology - DM/email me if you are interested in giving a departmental seminar @columbia systems biology. Please RT and spread the word!
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