@knutdrescher

I love science and discovering new things.

 Biozentrum, Basel, Switzerland
drescherlab.org/
Joined October 2017
  • Tweets259
  • Following537
  • Followers2.4K
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We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation. Details👇: nature.com/articles/s41564-0…

Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation

Nature Microbiology - Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

nature.com
Nature Microbiology@NatureMicrobiol3 Jan 2025
OUT NOW: Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation @knutdrescher @sneakystaph @biozentrum nature.com/articles/s41564-0…

Bacteria use exogenous peptidoglycan as a danger signal to trigger biofilm formation

Nature Microbiology - Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

nature.com
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🔬✨ Opening of the #LatsisSymposium on Smart Microscopy @EPFL_en with Laurène Donati, @MartinVetterli, @SulianaManley & Andy Oates @OatesLab! 🌍🔗 A fantastic event uniting 150 top scientists to explore the future of microscopy through #AI, #MachineLearning, and #Automation.
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We have set up a new Masters degree program, the MSc Physics of Life, at the Biozentrum in Basel. I am looking forward to training the next gen avant-garde at the interface of physics, maths, engineering and biology! 👉Scholarships available👈
Biozentrum, University of Basel@biozentrum4 Mar 2024
NEW: MSc in Physics of Life – training in cutting-edge research at the interface of physics, mathematics, engineering and life sciences. Apply now and be one of the first students of the program. Scholarships available. @biozentrum @UniBasel_en ow.ly/r6h950QKBTX
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Replying to @NatureMicrobiol
@NatureMicrobiol Comment by Christoph Dehio and colleagues Revitalizing antibiotic discovery and development through in vitro modelling of in-patient conditions nature.com/articles/s41564-0… @urs_jenal @JWVeening @alexpersat @knutdrescher @AHarms485 @AdrianEgli78 @Basler_Lab
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The last article from Yasmine Dergham PhD is now published in Nature Communications "Direct comparison of spatial transcriptional heterogeneity across diverse Bacillus subtilis biofilm communities" rdcu.be/drAfi
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We developed a method for spatiotemporal transcriptome measurements during bacterial swarm development, which revealed cross-feeding across generations! Now out: 👇 nature.com/articles/s41564-0…

Simultaneous spatiotemporal transcriptomics and microscopy of Bacillus subtilis swarm development...

Nature Microbiology - Spatiotemporal transcriptomes during multicellular development of Bacillus subtilis swarms reveal supra-generational cooperation.

nature.com
François Mayer@Francois_Mayer116 Nov 2023
How do microbial communities develop? Combining live-cell microscopy with a robotic arm for sampling reveals a cross-feeding mechanism during Bacillus subtilis swarm development. Congrats to @HannahJeckel @no_show3 @knutdrescher & colleagues! nature.com/articles/s41564-0…

Simultaneous spatiotemporal transcriptomics and microscopy of Bacillus subtilis swarm development...

Nature Microbiology - Spatiotemporal transcriptomes during multicellular development of Bacillus subtilis swarms reveal supra-generational cooperation.

nature.com
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How to measure spatiotemporal transcriptomes? Just build a robotic arm that is controlled by a smart microscope that makes live decisions based on what it observes 😉 Here is our version:
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Interested in biofilm image analysis? We just released a major update to the BiofilmQ software, to integrate single-cell analysis capabilities. drescherlab.org/data/biofilm… We also give 3 BiofilmQ workshops, as part of the online I2K conference i2kconference.org/workshops
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Knut Drescher retweeted
Urs Jenal@urs_jenal23 Sep 2023
Keep research councillors of SNSF involved in the evaluation of research grants secure.avaaz.org/community_p…

Keep research councillors of SNSF involved in the evaluation of research grants

Dear President, dear members of the Foundation Council of the SNSF,We, the undersigned, have been alarmed to learn of the substantive changes that have been planned for the future functioning of the...

secure.avaaz.org
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I have an opening for a PhD student working on molecular biology of bacterial biofilms. More info here: drescherlab.org/join.html
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Living multi-cellular systems have different cellular arrangements from nonliving multi-object systems. What causes this difference? Great work by Dominic Skinner, Jörn Dunkel @MITMath and colleagues. science.org/doi/full/10.1126…

Topological packing statistics of living and nonliving matter

A topological metric framework makes it possible to compare biological, physical and astronomical systems.

science.org
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Knut Drescher retweeted
Ben Engel@bengeliscious16 Aug 2023
The @biozentrum is recruiting new group leaders! Come join us!🤗 I know I'm biased, but trust me-- this place amazing! Great science! Great funding! Great life! Two calls right now: Broad general search: biozentrum.unibas.ch/open-po… Infection & Immunity: biozentrum.unibas.ch/open-po…
Knut Drescher@knutdrescher16 Aug 2023
Faculty opening: Assistant/Associate Professor in Molecular, Cellular or Systems Biology with broadly defined scope of topic. Location: my institute, @biozentrum in Basel. Deadline September 19. biozentrum.unibas.ch/open-po…
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Faculty opening: Assistant/Associate Professor in Molecular, Cellular or Systems Biology with broadly defined scope of topic. Location: my institute, @biozentrum in Basel. Deadline September 19. biozentrum.unibas.ch/open-po…
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Assistant/Associate Professor position in Infection and Immunity at my institute, @biozentrum in Basel. Deadline: October 10. biozentrum.unibas.ch/open-po…
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Knut Drescher retweeted
Roi Avraham@roi1avraham4 Jul 2023
Our work is out @PNASNews. We introduce scPAIR-seq: a high-throughput method for paired host profiling with multiplex-tagged bacterial mutants to analyze host-pathogen at single cell resolution. Congratulations to Ori Heyman and @noabossel pnas.org/doi/10.1073/pnas.22…
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We are #hiring ! Professorship in Infection and Immunity at the tenure-track assistant or tenured associate level. This position will be supported by the @biozentrum and the @NCCR_AntiResist: New Approaches to Combat Antibiotic-Resistant Bacteria". biped2.biozentrum.unibas.ch/…
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Dual strategy of hospital germ: Some bacteria colonize surfaces while others spread in the body. @JenalLab uncovers genetic switch behind this division of labor. An anti-biofilm compound flips the switch, thus dispersing biofilms. @biozentrum @UniBasel_en ow.ly/Sznb50OSsS8

Should I stay or should I go: Hospital germ’s dual strategy

Hospital germ practices division of labor: Some pathogens form a biofilm, while others spread in the body. Researchers at the Biozentrum uncovered a genetic switch behind this.

biozentrum.unibas.ch
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Bacteria harness the power of communities. Fascinating research by @knutdrescher team @biozentrum reveals that cholera bacteria form an aggressive biofilm – a cunning strategy to kill immune cells. @UniBasel_en @snsf_ch @NCCR_AntiResist @CellCellPress ow.ly/B5at50OLxrT
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Should I stay or should I go 🦠 lovely new study on bimodal regulation of Pseudomonas aeruginosa biofilm heterogeneity by @Jenal_Lab @biozentrum @UniBasel_en Readcube: rdcu.be/dd8Dg nature.com/articles/s41564-0…
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Bacterial biofilms form on human immune cells: how? Why? 👇 cell.com/cell/fulltext/S0092… W/ @LuciaVidakovic @roi1avraham @alexpersat @MikhalevaSofya @HannahJeckel @KerstinMicrob

Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae

For the human pathogen Vibrio cholerae, biofilm formation is not only a protective trait but also an aggressive trait where biofilms form on immune cells, encase and kill them, and then disperse.

cell.com
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