@KRASKickers

#KRAS 🎯cancer patient group for reliable Knowledge Research Advocacy & Survivorship. Survival of the strategic. #KickCancersKRAS - 🚫 #KRASholes

 International, ALL RAS cancers
kraskickers.org
Joined February 2020
  • Tweets5.1K
  • Following4.9K
  • Followers4.2K
551Media
At @ASCO #GI26 we presented our KRAS KICKERS Trial Finder. Personalized: KRAS G12D, CRC, US trials Results (in 4 minutes): 20 trials go to KRASHUB.ORG in beta - would love your feedback abstract asco.org/abstracts-presentat… FYI: G12V - 8 trials for CRC G12R - 7 trials for CRC
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#KRAS #ESMO26. .
OncLive.com
@OncLive4h
INCB161734 $INCY KRAS G12D inhibitor at 1200 mg +/- cetuximab in refractory metastatic #colorectalcancer shows promising ORR 36% DCR 100% mPFS 7.2 months with combo, no unexpected treatment related adverse events, improved suppression of KRAS G12D ctDNA with combo @Incyte #ESMO26 @myESMO #crcsm
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#ESMO26 #KRAS G12D
Dr. Cathy Eng
@CathyEngMD4h
Phase I encouraging results with INCB161734 (#KRAS #G12D) inhibitor 1200 mg + cetuximab (N=25) in #colorectal #cancer - No grade 4/5 SAE's - ORR = 36% - DOR = 100% - Median PFS = 7.2M #ESMO2026 #RAS @Incyte @OncoAlert
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#ESMO26 KRAS G12C
Business-News-Today.com
@BNTBriefingOct 20
Frontier to reveal first FMC-376 clinical responses in KRAS G12C lung cancer pharmadevicenews.com/frontie… @FrontierMeds will disclose the first human data for FMC-376 on October 25, including tumor responses in patients previously treated with KRAS G12C inhibitors. Unlike established OFF-state inhibitors, FMC-376 is designed to target both active and inactive KRAS G12C. The key question is whether this dual mechanism can produce durable responses without unacceptable toxicity. #FrontierMedicines #FMC376 #ESMO2026 #KRASG12C #LungCancer #NSCLC #PrecisionOncology #TargetedTherapy #ClinicalTrials #Biotechnology

Frontier to reveal first FMC-376 clinical responses in KRAS G12C lung cancer

Frontier Medicines, a privately held biotechnology company operating in Boston and South San Francisco, announced on October 16, 2026, that it will present the first clinical results for FMC-376, its...

pharmadevicenews.com
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Frontier to reveal first FMC-376 clinical responses in KRAS G12C lung cancer pharmadevicenews.com/frontie… @FrontierMeds will disclose the first human data for FMC-376 on October 25, including tumor responses in patients previously treated with KRAS G12C inhibitors. Unlike established OFF-state inhibitors, FMC-376 is designed to target both active and inactive KRAS G12C. The key question is whether this dual mechanism can produce durable responses without unacceptable toxicity. #FrontierMedicines #FMC376 #ESMO2026 #KRASG12C #LungCancer #NSCLC #PrecisionOncology #TargetedTherapy #ClinicalTrials #Biotechnology

Frontier to reveal first FMC-376 clinical responses in KRAS G12C lung cancer

Frontier Medicines, a privately held biotechnology company operating in Boston and South San Francisco, announced on October 16, 2026, that it will present the first clinical results for FMC-376, its...

pharmadevicenews.com
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Just seen at #ESMO26 RAS Biology session with Professor Chiara Abrogrio @AmbrogioLab
Bjoern Papke@papkephdAug 27
Replying to @nytimes
@nytimes cited my webpage rasinhibitors.com as the source for the number of RAS inhibitors in active clinical development, in today's article on what follows the daraxonrasib approval. rasinhibitors.com #RAS #TargetedTherapy

RAS Inhibitors in Clinical Development

A curated overview of RAS inhibitors in clinical development.

rasinhibitors.com
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KRAS Kickers retweeted
Anirban Maitra@Aiims1742Oct 24
So ready for the NCI p53 initiative!
The Cancer Letter
@TheCancerLetterOct 23
Kevan Shokat (@kevansf) made KRAS druggable. With daraxonrasib now in the clinic, he is “all in” on the ultimate target: p53 Shokat was named 2026 Stephenson Global Prize winner cancerletter.com/conversatio…
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#ESMO26 #ESMO2026 #JetLag #ESMOAmbassadors ⏰
🤖 Made with AI
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KRAS Kickers retweeted
Anirban Maitra@Aiims1742Oct 23
Mechanism wise there has got to be a bi-directional crosstalk between wild type RAS and PRMT5 First Daraxonrasib has greater ORR than Zoldonrasib per press release, and second: “and partly because targeting PRMT5 may attenuate some of Rasonque’s toxicities”
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KRAS Kickers retweeted
PDBrown
@PDBrownOncOct 5
Placebo Controlled Randomized Trial: Memantine given w/Brain RT Improved Cognitive Outcomes & QOL 1/3 sciencedirect.com/science/ar…
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Today at #ESMO26: Zev Wainberg will present additional subgroup analyses from the phase 3 RASolute 302 study of daraxonrasib vs. chemotherapy in previously treated metastatic pancreatic adenocarcinoma. @MSKCancerCenter's @EileenMOReilly is the senior author. 📅 October 23 | 2:22 p.m. CEST
A promotional graphic featuring headshots of Zev Wainberg and Eileen O'Reilly and the presentation title and date.

ALT A promotional graphic featuring headshots of Zev Wainberg and Eileen O'Reilly and the presentation title and date.

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KRAS Kickers retweeted
Grainne O'Kane
@graokaneOct 23
AMPLIFY-7P randomised ph2 ✅7-valent(camupepimut) mKRAS lymph node targeted amphiphile ➡️curative intent & no recurrence <6mth #PDAC ✅T cell responses,primary endpt-ve ➡️benefit in ctDNA-ve& no rads? ➡️DFS @6mth benefit of 14% p=0.056 ✅ph3 planned @myESMO @OncoAlert #ESMO26
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Zev Wainberg presents subgroup analyses from phase 3 RASolute 302 study of #daraxonrasib in patients with previously treated metastatic #PDAC at #ESMO26 (part 1) #ESMOAmbassadors @myESMO
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KRAS Kickers retweeted
Arndt Vogel
@ArndtVogelOct 23
AMPLIFY-7P ph 2 study: Seven-valent mKRAS-specific lymph node targeted amphiphile immunotherapy versus observation in resected PDAC) #ESMO26 #ESMOAmbassadors 👉 Targeting lymph nodes to activate T-cells 👉T-cells response in 99% of pts 👉poor outcome in ctDNA pos pts 🧐promising data, specifically in pts with Tcell response @myESMO
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KRAS Kickers retweeted
Grainne O'Kane
@graokaneOct 23
#LBA82 subgroup analysis RASolute 302 #PDAC ➡️HR for OS across subtypes 0.32-0.46 ➡️G12R 0.61 (0.29-1.30) ➡️RAS WT numbers small (3%) but still OS benefit! 🤔perhaps ORR and mPFS not as pronounced in these populations! ✅std second line treatment @myESMO #ESMO26 @OncoAlert
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#ESMO26 🚀 RASolute 302 | Phase III 👥 500 pts | Previously treated mPDAC 💊 Daraxonrasib (RAS(ON) inhibitor) vs chemo 📈 OS: 13.2 vs 6.7 mo (HR 0.40) 🧬 OS benefit by RAS genotype: 🔹 G12D: HR 0.49 🔹 G12V: HR 0.32 🔹 G12R: HR 0.61 📊 PFS: HR 0.55 (BICR) 🎯 ORR: 32% vs 11% 💡 new SOC! @OncoAlert
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Wow 🤩 #ESMO26 Plus 3 papers in @JCO_ASCO 💪 @myESMO @OncoAlert @Annals_Oncology @ESMO_Open @TheLancet @JAMA_current @TheLancetOncol @NEJM @Nature @NatureMedicine
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Coming up at #ESMO26: MSK gastrointestinal medical oncologist @EileenMOReilly will present the AMPLIFY-7P randomized phase 2 study comparing an mKRAS-specific immunotherapy with observation in patients with resected pancreatic ductal adenocarcinoma. 🗓️ Friday, October 23 | 2:32 p.m. CEST
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Join us at #ESMO26 for the "Advancing the Frontiers of Lung Cancer Care" symposium, where I will discuss KRAS, SCLC, immunotherapy, and ADCs with Dr. @FSkoulidis, Dr. Margarita Majem, and @TerriConneran. Monday, October 26, 13:00 CET, Oviedo Auditorium, Hall 5, IFEMA Madrid!
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📍Don’t miss the lecture @myESMO #ESMO26 “Drugging the undruggables: The next wave of targeted therapies” @OncoAlert @oncodaily Link - cslide.ctimeetingtech.com/es…
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MeDucation
@MeDucationaiOct 21
Put @VivekSubbiah's #ESMO26 lecture on drugging the undruggables on your list. The pearl for fellows: KRAS G12C went from undruggable to approved by trapping the inactive GDP-bound state, and the next wave is going after the active RAS(ON) state instead.
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