New research in Cell Reports Medicine! How does a newborn’s immune system change during the first 48 hours of life? Our team profiled 324 plasma proteins, cytokines, and chemokines across 906 samples from 679 healthy Gambian newborns, which enabled us to assemble ontogenetic trajectories for the first 48 hours of life at a bi-hourly resolution. The key findings could be confirmed in an independent cohort collected in Papua New Guinea. We found that: • The first 48 hours reveal distinct phases of immune development, highlighting the dynamic nature of early-life immune ontogeny that are easily missed when sampling only by day of life. • The patterns were robust across the hundreds of newborns and enabled the construction of a neonatal immuno-molecular clock, which identified normative processes during the earliest postnatal period. • The immune development showed distinct sex-dependent differences, with the newborn girls’ immunological age being on average four hours advanced as compared to boys. These findings highlight just how rapidly the neonatal immune system changes immediately after birth and why high-resolution sampling matters for understanding early-life immunity. Congratulations to Tue Bjerg Bennike, Hanno Steen, Kinga Smolen, Tobias Kollmann, @levy_o, Beate Kampm, William Pomat, and the entire EPIC-HIPC Consortium. Most importantly, thank you to all the participating families who made this work possible. 📄 Read the paper: doi.org/10.1016/j.xcrm.2026.… @BostonChildrens, @harvardmed, @aalborg_uni #PrecisionVaccines #NeonatalImmunology #SystemsImmunology #Proteomics #GlobalHealth

PVP Director, @levy_o, will be speaking at the World Vaccine Congress Europe this October in Amsterdam! 🌍 Join us at WVC EU to meet global leaders across the vaccine value chain and discuss the latest innovations shaping the future of global health! 💉 Use this code SBSPK25 to get an extra 25% off your ticket! i.snoball.it/p/ABD3QRfK/l/12 #WVCEU #WorldVaccineCongress #VaccineInnovation #Speaker #Amsterdam @vaccinenation

Members of the PVP, including @levy_o, Utsa Bhaduri, Annmarie Hoch, and Donato Amodio, presented during the #IDEAL annual meeting, hosted at Johns Hopkins Bloomberg School of Public Health. @JohnsHopkinsSPH @NIH #NIAID

Out Now in @Nature Led by @DellMedSchool along with @PrecVaccines and 13 biomedical research institutions across the United States, the #IMPACC group have discovered that #COVID19 reactivates multiple dormant viruses in hospitalized patients correlating with development of acute and #longCOVID. These findings expand understanding of chronically infecting viruses and could inform development of strategies to combat their reactivation. @MelamedEsther @colemag9, Jing Chen, Annmarie Hoch, Al Ozonoff, @KingaSmolen, @levy_o, Hanno Steen, @JoannDArce #Coronavirus Read full article here: nature.com/articles/s41586-0…

Out in @bloodrci article led by Abhinav Checkervarty, with our own @PrecVaccines co-authors: Asimenia Angelidou, @JoannDArce, Kerry McEnaney, @KingaSmolen and @levy_o. 720 Gambian neonates, enrolled in the EPIC-HIPC study, were genotyped to identify those with Sickle Cell trait (SCT). We found that newborns with SCT demonstrated distinct molecular signatures compared to those without and observed enrichment of pathways associated with Sickle Cell disease. #SickleCell, #SickleCellDisease @PROOFCentre @HLIStPauls Read the full article here: pubmed.ncbi.nlm.nih.gov/4236…

New review published in @NatImmunol re #IDEALpediatrics (Immune Development in Early Life) research group including Paolo Palma @bambinogesu, @donnafarber3, @LizaKonnikova at @YalePediatrics and @levy_o at @BostonChildrens identifies the first 1,000 days as a decisive window for immune development and for future risk of infections, #asthma, #allergy, and low #vaccine responses. This impactful review highlights the #NIH #NIAID-supported #IDEALpediatrics collaboration between @bambinogesu and @bostonchildrens Read full review here: pubmed.ncbi.nlm.nih.gov/4217…

Thank you to the incredible panel of researchers who presented at the Immune Development in Early Life Hot Topic Symposium this weekend at @PASMeeting #PAS2026. Their work highlights just how critical and dynamic early immune development is in pediatrics. By continuing to study this window, we can help improve outcomes, better understand how to shape immune responses, and drive new discoveries. We look forward to continuing the conversation at #PAS2027 in Minneapolis, MN, and sharing our next wave of findings in this exciting field. From left to right: Dr. Xiaobin Wang, @levy_o, Dr. Oluwabunmi Olaloye, Dr. Octavio Ramilo, Dr. Paolo Palma. #ImmuneDevelopment #EarlyLifeImmunity #ImmuneTrajectories #PrenatalExposures #vaccines #IDEAL

Tomorrow, Sunday April 25th, @levy_o will chair the @PASMeeting Hot Topic Symposium: “Immune Development in Early Life (IDEAL) shapes vaccine response, respiratory infectious disease and asthma”. The session will occur from 2:30-4:00 pm in 213 West in the Thomas M. Menino Convention & Exhibition Center. The symposium will feature presentations from leading researchers in the field followed by a Q&A session. We hope you will join us in attending this special session! #PAS2026 #ImmuneDevelopment #IDEAL #PrecVaccinesNetwork

Members of the @PrecVaccines team and Precision Vaccines Network will be attending and presenting at @PASMeeting this weekend! If you are attending, please feel free to stop by our sessions to hear updates on our research, insights, and discoveries! @levy_o @JoannDArce @BiotechByron @KingaSmolen @elissa_weitzman #PASBoston #PAS2026 #PAS #Immunology #Vaccines #PrecisionVaccinesNetwork

Dr. Mercy Prabhudas, Program Officer at the @NIH, National Institute of Allergy and Infectious Diseases (NIAID), visited us today from Maryland. It was our pleasure to host her at our @PrecVaccines space. @NIH_Innovates Pictured: @levy_o, @AmodioDonato, Paolo Palma, @D_J_Martino, Kinga Smolen PhD, Kerry McEnaney, Marco Sanna, Asimenia Angelidou, Joann Diray Arce, Mercy Prabhudas, Annmarie Hoch, Utsa Bhaduri

New publication out in @JACIGlobal. In this #NIH supported randomized study, our team examined how two newborn vaccines given in many parts of the world via the Essential Program on Immunization (EPI), Hepatitis B vaccine (#HBV) and bacille Calmette-Guérin (#BCG), interact when given in the first week of life. The trial was conducted with partners in The Gambia and Papua New Guinea, bringing together clinical sites and research teams across Africa, Oceania, Europe, North America, and Australia. What we found: Our results support the immunogenicity of HBV in newborns and examine how the timing of HBV and BCG vaccination may influence early immune responses. These findings help clarify how vaccine scheduling in the first days of life can shape protection against hepatitis B, an important step towards precision vaccines for the very young. This work reflects a global collaboration spanning institutions and field sites including: • @mrcunitgambia • @pngimr • @BostonChildrens @harvardmed • @broadinstitute and • partners across Canada, Australia, the UK, Belgium, and Germany. We are grateful to the families who participated, the clinical teams in The Gambia and Papua New Guinea, and the many collaborators in the @EPICVaccines consortium who made this study possible. Importantly, this work evaluates licensed vaccines already used worldwide and focuses on understanding how newborn immune responses develop, not on experimental vaccine policies. 📄Read the article here: bit.ly/4c1cu4F #Vaccines #NeonatalImmunology #HepB #BCG #GlobalHealth #PrecisionVaccines @LSHTM_Vaccines @PrecVaccines @JoannDArce, Caitlin Syphurs, Tobias Kollmann, @levy_o, @PeterCRichmond , Anita van den Biggelaar, Beate Kampmann, @bukkyidoko, Al Ozonoff

PVP Director, @levy_o will be attending and speaking at the Massachusetts Medical Society Future Health: Best Practices for Advancing Care President's Breakfast on Saturday, March 21st! 🗓️ #vaccines #immunology Register here: FutureHealthBest.org #vaccines #immunology