@lkmoeller

BioEng PhD candidate @Caltech | Elowitz lab | prev. @MIT, @broadinstitute, @ETH

 Los Angeles, CA
Joined March 2022
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  • Following117
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Excited to share our recent work on „synpoptosis“ circuits for user-controlled, active induction of cell death in mammalian cells. Thanks to @ShiyuXia and the whole Elowitz lab!
ElowitzLab
@ElowitzLab3 May 2024
Our new paper on “synpoptosis” circuits, led by the amazing @ShiyuXia, is now out: sciencedirect.com/science/ar… (1/3)
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Check out this thread by @altaetran to learn more about our recent work published in @ScienceMagazine!
Han Altae-Tran@altaetran28 Nov 2023
Our latest work exploring ultra rare CRISPR systems with new big data algorithms has been published by @ScienceMagazine! @zhangf @soumya_kannan12. This thread will unwrap how we found needles in a haystack of metagenomes. Let's dive in! (1/8) doi.org/10.1126/science.adi1…
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Using big-data approaches to rapidly search massive amounts of genomic data, a new search algorithm has revealed thousands of rare new CRISPR systems. broad.io/CRISPR-Zhang-112323
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The clustering algorithm FLSHclust identifies previously unknown CRISPR-linked systems using a mining approach with great potential for advancing biotechnology development in both research and the clinic. #NBThighlight science.org/doi/10.1126/scie…

Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering

A clustering algorithm, FLSHclust, was developed and applied to discover 188 previously unreported CRISPR-linked gene modules.

science.org
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Lukas Moeller retweeted
nature
@Nature24 Nov 2023
‘Treasure trove’ of new CRISPR systems holds promise for genome editing go.nature.com/418u4Ol

‘Treasure trove’ of new CRISPR systems holds promise for genome editing

Nature - An algorithm that can analyse hundreds of millions of genetic sequences has identified DNA-cutting genes and enzymes that are extremely rare in nature.

nature.com
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Happy to share some of the work I contributed to as a visiting student in the lab of @zhangf at @MIT. Led by @altaetran and @soumya_kannan12, the study uncovers diverse, previously unknown CRISPR systems using FLSHclust, a new algorithm for fast and deep protein clustering.
Science Magazine
@ScienceMagazine23 Nov 2023
Using a new algorithm called FLSHclust, researchers have revealed rare and previously unknown #CRISPR-Cas systems. The approach and results provide novel opportunities for understanding the vast functional diversity of microbial proteins. scim.ag/4W6
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Excited to share our work on #RecursiveEditing! Thanks to everyone who contributed to this project, particularly to Eric Aird and @jcornlab
Jacob Corn@jcornlab5 Aug 2022
Today in @natcomms we report #RecursiveEditing: a way to drive high levels of #CRISPR #HDR without manipulating the cellular factors or state. Project co-led by Masters' student Lukas Möller and postdoc Eric Aird. nature.com/articles/s41467-0… 🧵

Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

Nature Communications - CRISPR-Cas induced HDR methods tend to have a low efficiency. Here the authors report an HDR improvement strategy, Recursive Editing, that selectively retargets undesired...

nature.com
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