Montréal, Québec
Joined July 2014
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Bratislav Misic retweeted
1/ 🚨 Just out in @NatureNeuro! 🧠
We profiled >6,000 features of brain dynamics across humans + monkeys, mice, fish and worms 🧑🐒🐒🐁🐟🪱 to find a shared neural endpoint of anaesthesia: spatiotemporal isolation of local activity 🧵
🔗 doi.org/10.1038/s41593-026-0…
7️⃣ We really like this project because it explores how support systems—in this case whole-brain glymphatic organization—relate to diverse aspects of brain physiology and disease vulnerability.
led by the talented @Tahmine21189829
code + maps: github.com/netneurolab/taher…
6️⃣ There are a few other fun things in the supplement, including the mapping of other aquaporins and comparisons with MRI measurements of the glymphatic system (intrathecal CSF tracer gadobutrol).
5️⃣ Finally, we show that peritumoral edema is most frequent in AQP4-enriched regions and is further shaped by regional inflammatory tone.
4️⃣ Incorporating normative PET markers of neuroinflammation typically strengthens the spatial alignment between AQP4 expression and disease atrophy, suggesting that inflammatory tone and glymphatic-related architecture jointly shape vulnerability.
3️⃣ Turning to neurodegeneration, we find that atrophy patterns across multiple neurodegenerative diseases co-localize with AQP4 expression—most strongly for tau and TDP-43 proteinopathies—and high-atrophy regions lie close to AQP4 hotspots.
2️⃣ Linking AQP4 expression to vascular organization, we find that AQP4-enriched regions show lower normative blood perfusion and lower vein density, suggesting that this axis is not simply explained by vascular supply or large-vessel anatomy.
1️⃣ Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products.
Here we use AQP4 gene expression as a molecular anchor to reconstruct a whole-brain glymphatic-related topography.
Spatial organization of AQP4 water channel expression in the human brain | doi.org/10.1126/sciadv.aeg81…
Aquaporins are a key component of the glymphatic system. How are they distributed + how do they relate to brain function and dysfunction? @ScienceAdvances ⤵️
4️⃣ All built and maintained by our trainees, led by
@liuzhenqi0303 @VinceBazz
Code: github.com/netneurolab/netne…
Documentation: netneurolab.github.io/netneu…
3️⃣ We showcase three walkthroughs of biologically-relevant questions that can be answered using netneurotools, related to structure-function coupling, multimodal connectivity, dynamics and gradients.
2️⃣ By design, netneurotools is trainee-centric and focuses on accessibility and usability. The functions are grouped into intuitive modules, covering the full lifecycle of a project.
Like "desire paths" in urban design — we only pave the routes people are already walking.
1️⃣ Neuroimaging is complex: multiple data types, formats, and specialized packages.
netneurotools is our lab’s Swiss army knife: functions that we often use but that are not part of any established pipeline.
Code: github.com/netneurolab/netne…
Documentation: netneurolab.github.io/netneu…
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s41596-026-0…
Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @NatureProtocols ⤵️
Bratislav Misic retweeted
An incredible feeling, knowing that the European Union believes in our work & and has decided to back my vision for the future of integrative neuroscience 🧠
Grateful beyond words to the collaborators & mentors who made this possible: here's to doing more science together! 🎉
NEWS: Exceptional early-career researchers awarded 2026 European Research Council Starting Grants
Congratulations to Dr Andrea Luppi @OxPsychiatry, who will use the ERC Starting Grant to develop a new ‘functional coordinate system’ for the brain.
medsci.ox.ac.uk/news/excepti…
ALT Aerial view of circular Radcliffe Camera and All Souls college.
Bratislav Misic retweeted
Out now in @PNASNews
We present a new metabolism-weighted brain connectome that incorporates each region’s energy expenditure into the mapping of brain connectivity.
pnas.org/doi/10.1073/pnas.25…
Bratislav Misic retweeted
The Neuroimaging and Brain Networks Lab at Universidad de Sevilla will be at #OHBM2026. We will be presenting our work on normative modeling in schizophrenia, trauma, computational models of structural connectivity, classification analysis and polygenic risk of psychopathology.
Bratislav Misic retweeted
Our latest work is now out in @NatureNeuro 🎉
Using brain scans in 🐭mice and humans 👨 we show that variable patterns of brain activity in #autism reflect distinct underlying biological mechanisms!
👉nature.com/articles/s41593-0…
Bratislav Misic retweeted
🔥Our opinion piece with @DuncanAstle on “why we might be better off accepting and embracing the fact that the brain’s connectivity profile is in no way optimal” is now out on @TrendsCognSci. There, we discuss implications for Neuro-AI and psychopathology.
cell.com/trends/cognitive-sc…
Bratislav Misic retweeted
In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests.
Here's our new preprint doi.org/10.64898/2026.05.17.… led by @tianchuzeng @kkli20111 @ZShaoshi @ten_photos 1/N
