postdoctoral researcher tumor biology-immunology-COPD, predoc @degradome, too many postdocs to count @myc @hif @autoimmunity @COPD @lungcancer @DKFZ
Joined January 2013
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Very happy that this is out! Thanks to the work of many passionate scientists from Academia, Industry and Clinics, to the generosity of #COPDpatients. High-resolution #transcriptomic and #epigenetic profiling ids novel #COPD regulators #Multiomics #humanLungFibroblasts
We completed the first whole genome #DNAmethylation profiles in #copd, revealing potential disease regulators 👇.
High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD embopress.org/doi/10.15252/e…
#epigenetics, #wgbs 🧵
MariaLlamazaresPrada retweeted
Figeno, my visualization tool for genomics🎨🧬, is now published in Bioinformatics! doi.org/10.1093/bioinformati…
It can generate publication-quality figures for sequencing data along genomic coordinates: bigwig, HiC, @nanopore data with base modifications, and WGS with CNAs and SVs.
MariaLlamazaresPrada retweeted
I'm excited to share our preprint "Pyjacker identifies enhancer hijacking events in acute myeloid leukemia including MNX1 activation via deletion 7q": doi.org/10.1101/2024.09.11.6…. This is my main PhD work and a massive collaborative effort.
🧵👇
MariaLlamazaresPrada retweeted
Did you ever wonder how a cell decides its fate? We review how #repression builds critical guardrails in Waddington's landscape, guiding cells to their fate, and discuss how #safeguard repressors ensure that cells don't stray off-path. @DKFZ @UniHeidelberg doi.org/10.1038/s44320-024-0…
MariaLlamazaresPrada retweeted
Very happy to share Ria Pinioti's work published in Cancer Immunology Research, revealing that #fucosylation is very important for the maintenance of the suppressive function of #Tregs in cancer. Thanks to all the collaborators for the work!
@vib_ccb @Onco_KULeuven
🤯 What the #fucosylation?
@MazzoneLab (@vib_ccb) found that this metabolic process can turn down T cell response against cancer cells, leading to worse prognosis. A discovery that can help enhance the patient’s own immune system against #cancer cells.
vibbio.tech/3QVdGwO
MariaLlamazaresPrada retweeted
Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD) biorxiv.org/cgi/content/shor… #bioRxiv
MariaLlamazaresPrada retweeted
I am happy to share that @NatureComms has published our latest research from the @DKFZ.
DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts
Here’s the link to the article:
nature.com/articles/s41467-0…
👇
1/7
MariaLlamazaresPrada retweeted
𝗦𝗰𝗣𝗼𝗹𝗶 𝗘𝗻𝗮𝗯𝗹𝗲𝘀 𝗠𝘂𝗹𝘁𝗶-𝗦𝗰𝗮𝗹𝗲 𝗥𝗲𝗽𝗿𝗲𝘀𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻𝘀 𝗼𝗳 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗦𝗮𝗺𝗽𝗹𝗲𝘀
👉For a brief insight: Check out our news: 🔗t1p.de/vmtph
@fabian_theis @mo_lotfollahi @CompHealthMuc
By learning representations for both cells and various condition covariates, scPoli facilitates atlas-level integration and analysis of single-cell genomics datasets with improved interpretability.
@fabian_theis @mo_lotfollahi @HelmholtzMunich
OA paper:
nature.com/articles/s41592-0…
MariaLlamazaresPrada retweeted
(1/n)scPoli is now published in @naturemethods shorturl.at/jvyL0; see below. scPoli is an open-world learner for multi-scale analysis of scRNAseq/ATAC-seq across samples and species with cell types and conditions hierarchies. With scPoli you can:
1/n Excited to share our new work with @fabian_theis on population-level integration of single-cell data led by amazing Carlo De Donno. We present scPoli to learn representation for cell types and samples that can be updated with new cells and samples (tinyurl.com/ywkw5nnw)
MariaLlamazaresPrada retweeted
Cells live and interact in 3D tissues but pathology and spatial omics typically rely on 2D sections...
Excited to share our latest efforts in @N_Rajewsky lab to generate a 3D, multimodal atlas of a human tumor!
Find out what we learned: video + 🧵!
🔗 bit.ly/3D_lung_cancer
MariaLlamazaresPrada retweeted
Two neighboring cells can be so different! Releasing scDVP - single-cell #DeepVisualProteomics for combined imaging and mass spectrometry-based proteomics in the intact tissue context. One cell at a time. nature.pulse.ly/13a4oy6x1y @naturemethods Here’s a summary! (1/n)
MariaLlamazaresPrada retweeted
Happy to share our new article 'Multiparameter prediction of myeloid neoplasia risk' now published at @NatureGenet. nature.com/articles/s41588-0…
MariaLlamazaresPrada retweeted
⏰Abstract deadline has been extended! You can send your abstracts by August 15th! Lots of great scientific exchanges are awaiting, and we would love to have you there 🔜💻
MariaLlamazaresPrada retweeted
🔜🚨 Less than 2 weeks for abstract submission 💻 Come share with fellow postdocs in cancer research this amazing conference with lots of networking opportunities and terrific keynotes 🤩 Senior #PhDs and #newPI are also welcome! Sounds great, right? Join us and spread the word😉
Scientific discussion at its best, glad to be part of the moderators in this interesting and very important debate, read both, it’s important
nature.com/articles/s43018-0…
nature.com/articles/s43018-0…
MariaLlamazaresPrada retweeted
👏Congrats to our #AI expert Prof. Fabian Theis - elected as ISCB Fellow!
💡Prof. @fabian_theis was recognized for his exceptional pioneering work in applying #MachineLearning resulting in significant advancements in AI-based #BiomedicalResearch.
👉t1p.de/2tq4u
MariaLlamazaresPrada retweeted
Twitter messed up my previous thread, but this is too important to let it slide:
Here are (again) my summary & thoughts on early detection & an amazing work
Deep learning model trained on 9 million patient records in Denmark & US finds people at risk for pancreatic cancer
🧵🧵
MariaLlamazaresPrada retweeted
Shout out to your fellow cancer researchers! Please RT, and if you are last year Ph.D., postdoc, or a brand new junior PI, we can wait to hear from you!
🚨🎉 We're happy to announce that abstract submission for the @PostdoCaReEu conference is open 🥳 tinyurl.com/postdocareu Deadline is 31st July! Check the conference website postdocareeu.com/conference2… and the amazing keynotes! Questions? Contact us at [email protected] and RT!
