@HeyJosch

Data-driven scientist | from confusion to understanding @HeyJosch@genomic.social

 Deutschland
Joined May 2018
  • Tweets135
  • Following381
  • Followers236
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I am happy to share that @NatureComms has published our latest research from the @DKFZ. DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts Here’s the link to the article: nature.com/articles/s41467-0… 👇 1/7

DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element...

Nature Communications - Epigenetic therapies are known to synergize with immunotherapies through the de-repression of endogenous retroviral element (ERV)-encoded promoters. Here the authors...

nature.com
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Joschka Hey retweeted
DKFZ@DKFZ12 Apr 2024
Ashish Goyal, Jens Bauer und Joschka Hey erhalten den diesjährigen #WaltraudLewenzPreis für ihre Arbeit über die Identifizierung von Neoantigenen, die von neu aktivierten Transkripten bei epigenetischen Therapien kodiert werden. Herzlichen Glückwunsch! 👏 @DKTK_
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Trackplot: a fast and minimal dependency R script for epigenomic enrichment plots academic.oup.com/bioinformat… github.com/PoisonAlien/track…
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Congratulations to all authors involved in this beautiful study about Juvenile Myelomonocytic Leukemia! I am pleased to have contributed to this work that not only demonstrates the oncofetal reprogramming of this childhood cancer, but also identifies therapeutic vulnerabilities.
Translational Cancer Epigenomics@TransCanEpi2 Nov 2023
Exciting findings in #childhoodcancer #oncofetal reprogramming of postnatal #stemcells and CD52 as a novel therapeutic target in #pediatric #leukemia New preprint from our lab by @mp_hartmann @MaxSchoenung @dblipka1 biorxiv.org/content/10.1101/…
https://www.biorxiv.org/content/10.1101/2023.10.27.563754v1

ALT https://www.biorxiv.org/content/10.1101/2023.10.27.563754v1

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Joschka Hey retweeted
DKFZ@DKFZ25 Oct 2023
Epigenetisch wirkende Medikamente ermöglichen, dass Bereiche des Erbguts abgelesen werden, die vorher blockiert waren. Das führt zur Bildung neuer mRNA und neuer Proteine, die das Immunsystem beim Erkennen von Krebszellen unterstützen könnten. @uktuebingen t1p.de/994hd
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Although my time as a Postdoctoral Researcher at DKFZ has come to an end, I feel fortunate to have the opportunity to continue working in the same field as a Senior Bioinformatics Scientist at @Cytoreason. 6/7
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Our main focus @Cytoreason is to utilize computational disease models to gain a better understanding of disease mechanisms, prioritize indications, and identify novel targets for various diseases. 7/7
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One in 400 people among the general population – and 1 in 40 Ashkenazi Jews – is born with mutations in the BRCA genes that increase the risk of several cancer types. It's not surprising then that these mutations keep cancer researchers busy. (1/3)
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Very happy that this is out! Thanks to the work of many passionate scientists from Academia, Industry and Clinics, to the generosity of #COPDpatients. High-resolution #transcriptomic and #epigenetic profiling ids novel #COPD regulators #Multiomics #humanLungFibroblasts
NGS Analysis Center, University Regensburg@NAC_Regensburg8 May 2023
We completed the first whole genome #DNAmethylation profiles in #copd, revealing potential disease regulators 👇. High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD embopress.org/doi/10.15252/e… #epigenetics, #wgbs 🧵
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We completed the first whole genome #DNAmethylation profiles in #copd, revealing potential disease regulators 👇. High‐resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD embopress.org/doi/10.15252/e… #epigenetics, #wgbs 🧵
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Delighted to share our story about enhancer hijacking event! First contributing article of my PhD @DKFZ . Many more to come hopefully 😉 @Nature nature.com/articles/s41375-0…

Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

Leukemia - Translocation t(6;7) in AML-M4 cell line GDM-1 results in MNX1 activation through enhancer-hijacking

nature.com
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🔥📢Read the new study led by our very own Editor-in-Chief C. Plass @DKFZ and R. Scherz-Shourval @WeizmannScience on the epigenetic reprogramming of #TumorAssociatedMacrophages and their #DNAmethylation landscape 🔓➡️doi.org/10.1002/ijc.34364 #breastcancer, #TumorMicroenvironment
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Joschka Hey retweeted
Joschka Hey@HeyJosch12 Dec 2022
Have you ever asked yourself how myeloid cells are reprogrammed to become tumor-associated macrophages (TAMs)? Our recent publication @IntJCanc indicates a prominent role of DNA methylation in the epigenetic reprogramming of TAMs! onlinelibrary.wiley.com/doi/… 1/n

DNA methylation landscape of tumor‐associated macrophages reveals pathways, transcription factors...

What's new?In many solid cancers, tumor-associated macrophages (TAMs) congregate in the microenvironment around the tumor. These TAMs have distinct gene expression profiles and help the tumor...

onlinelibrary.wiley.com
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Have you ever asked yourself how myeloid cells are reprogrammed to become tumor-associated macrophages (TAMs)? Our recent publication @IntJCanc indicates a prominent role of DNA methylation in the epigenetic reprogramming of TAMs! onlinelibrary.wiley.com/doi/… 1/n

DNA methylation landscape of tumor‐associated macrophages reveals pathways, transcription factors...

What's new?In many solid cancers, tumor-associated macrophages (TAMs) congregate in the microenvironment around the tumor. These TAMs have distinct gene expression profiles and help the tumor...

onlinelibrary.wiley.com
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Thanks to all friends and collaborators who made this project possible! Congratulations @CoralHalperin, @mp_hartmann, @MayerShimrit, @MaxSchoenung, @dblipka1, @shouval, and Christoph Plass 5/n
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If you haven’t seen our previous work on epigenetic reprogramming of the TME, check out our Cancer Research article on CAFs. aacrjournals.org/cancerres/a… 6/n
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