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La página donde podrás estar al día en Oncología de una forma crítica The page where you can stay up to date in Oncology in a critical way.

Joined June 2023
Right ON target: a new RAS-GTP inhibitor | Nature Reviews Cancer nature.com/articles/s41568-0…
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New data from EV302 Enfortumab Vedotin & pembrolizumab for upper tract disease (~25% of pts). UTUC has distinct biological features including more FGFR alterations. PFS & OS HR of 0.50 & 0.53 respectively in the subset is in line with the whole population (0.45 and 0.47) #EAU24
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Systematic review of TKI efficacy in NSCLC harboring uncommon EGFR mutations @JTOonline: - 1836pts, 38 studies - G719X, S768I, E709X, L747X; compound mtns; & PACC mtns: best ORR to 2nd-gen TKIs - L861Q best ORR to 3rd gen TKI @Alfdoc2 @OncoAlert #LCSM jto.org/article/S1556-0864%2… – at Alexandria, VA
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Tumor mutational burden as a predictive biomarker for non-small cell lung cancer treated with immune checkpoint inhibitors of PD-1/PD-L1 - PubMed pubmed.ncbi.nlm.nih.gov/3819…
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Subcutaneous atezolizumab (as opposed to IV therapy) is approved in the UK by the MHRA. It’s faster delivery for patients and reduces the increasing burden on systemic therapy units in cancer centres. It’s particularly relevant in the adjuvant setting. england.nhs.uk/2023/08/nhs-w…
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The latest update of the MONALEESA-3 trial is just published on @BCRJournal, reporting the longest OS to date for 1L patients in a phase 3 ABC trial (median OS with fulvestrant + ribociclib: 67.6 months). breast-cancer-research.biome…
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Adjuvant alectinib improves DFS vs chemotherapy in pts after resection of a stage IB to IIIA ALK+ NSCLC . Results of phase III trial ALINA spkl.io/60134l8TL. Impact on OS, rate of cross over and brain mets incidence to be followed. Likely to be a new SoC. @ALKPositiveinc
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