Professor at Karolinska Institutet specializing in the development of advanced cell imaging methods to uncover cell signaling mechanisms in health and disease.

Stockholm, Sweden
Joined May 2011
here Leslie and I celebrating first via Zoom with @RongFan8 and @Di_0579, together with our Molneuro Unit and coauthors as @peruhlen, and then at dinner with the lab
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We have a new Professor in the house @karolinskainst! Congrats Professor Jens Hjerling Leffler @HjerlingLeffler!
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Discover our new TRISCO method, which enables 3D RNA analysis at cellular resolution in intact brains. Explore a 3D rendering that reveals the deep brain expression pattern of the Parvalbumin gene, implicated in schizophrenia. @ScienceMagazine. science.org/doi/10.1126/scie…
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Excited to share our latest work published in Science!
This light-sheet microscopy three-dimensional rendering shows a first-of-its-kind mouse whole-brain mRNA analysis at single-cell resolution. Learn more in this week’s issue: bit.ly/3CCapy5
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This light-sheet microscopy three-dimensional rendering shows a first-of-its-kind mouse whole-brain mRNA analysis at single-cell resolution. Learn more in this week’s issue: bit.ly/3CCapy5
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We are excited to share our latest work, demonstrating that #calcium genes are tightly regulated and evolutionarily conserved, capturing functionally driven differences within radial glia and neuronal progenitors in the human and mouse brain. Check it out: biorxiv.org/content/10.1101/…
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We are looking for computational biologists who are interested in one of the following topics: protein design and engineering, biosensor development, single-cell technologies. Please send me a message or email if you are interested. ki.se/en/mbb/dagliyan-lab
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wow🤩🤩🤩, our wildDISCO @NatureBiotech paper presenting whole mouse body atlases has become its most downloaded article in 2023 (50K times) within a short time. Great follow-up studies are on the way, stay tuned 😉 nature.com/articles/s41587-0…
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The subtype identity of cortical inhibitory somatostatin neurons is predetermined and preserved during migration to their network by Sox6, a DNA-binding protein, a new study in @NeuroCellPress show. Research by @HjerlingLeffler, @bonafide_kasra, @hermanymv et al.
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Another great collaboration with @RongFan8 @Yale! Taking advantage of the great flexibility of Rong's DBit-seq to simultaneous spatially profile RNA & ATAC and RNA & histone mods genome wide, in the same brain tissue section! Check it out @Nature nature.com/articles/s41586-0…
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I am proud to share our latest research work describing TRIC-DISCO, a cool new 3D imaging method that can visualize RNAs across the whole brain with single-cell resolution. Check it out on BioRxiv: biorxiv.org/cgi/content/shor…
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We’re hiring! Seeking outstanding candidates to start their new labs at our department. All areas of fundamental biomedicine, but especially: Programmable medicines, Synthetic biology and Metabolomics. Generous startup packages. Apply here: ki.se/en/mbb/mbb-frontier-gr… (please RT)
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