@peter_finnie

Neuroscientist @UofT | Formerly @MIT & @mcgillu | Occasional appreciator of other things | he/him

 Toronto, Ontario
Joined December 2013
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Our preprint has now been published @CurrentBiology with a few new elements, thanks to 3 great reviewers! Check it out! In brief: The hippocampus is required for cortical (V1) plasticity elicited by visual sequences but not individual grating stimuli. authors.elsevier.com/a/1dTYi…
Peter Finnie@peter_finnie2 Mar 2021
Excited to finally share some of my postdoc work in which we investigated the role of hippocampus in visually-induced long-term V1 plasticity. Featuring Mark Bear and appearances by @robkomo81. 1/5
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Elon out here flexing his true talent: not innovating, but convincing people that he's innovating. – at Canada
Elon Musk
@elonmusk22 Mar 2024
First ever post made just by thinking, using the @Neuralnk Telepathy device!
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– at Toronto, Ontario
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Amazing day for my first tweet. Super excited to share my PhD research, published today @Nature. We find that contrary to popular belief, cortical reactivations predict the future rather than reflect the past. nature.com/articles/s41586-0… 1/10
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A neural network formalization of systems-level #memory consolidation that postulates that memories only consolidate when it aids generalization nature.com/articles/s41593-0…

Organizing memories for generalization in complementary learning systems

Nature Neuroscience - The authors derive a neural network theory of systems consolidation to assess why some memories consolidate more than others. They propose that brains regulate consolidation...

nature.com
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No nucleus? No problem! No DNA? Who cares! Histones? No need! Read our @biorxivpreprint on #Transgenerational Epigenetic Inheritance in animals that transmit to their progeny their cytoplasm but not their nuclei- Small RNAs are doin’ it for themselves!🧵 biorxiv.org/content/10.1101/…

Nucleus-Independent Transgenerational Small RNA Inheritance in C. elegans

Studies using C. elegans nematodes demonstrated that, against the dogma, animals can transmit epigenetic information transgenerationally. While it is now clear that in these worms ancestral RNA...

biorxiv.org
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Peter Finnie retweeted
Tony Zador@TonyZador16 Jun 2023
why does the executive director of SFN need to make $751K/yr??
This Post is from an account that no longer exists. Learn more
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Cholinergic input to mouse visual cortex primarily signals a movement state signal, with virtually no activation in response to visual stimuli or prediction errors. biorxiv.org/content/10.1101/…

Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5...

Acetylcholine is released in visual cortex by axonal projections from the basal forebrain. The signals conveyed by these projections and their computational significance are still unclear. Using...

biorxiv.org
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Recurrent pattern completion drives the neocortical representation of sensory inference biorxiv.org/content/10.1101/…
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Excited to share that our work is now published in @ScienceAdvances. science.org/doi/10.1126/scia… We found that Non-ionotropic NMDA receptor signaling offers a potential treatment for chronic pain by destabilizing spinal ‘pain memories’ and reversing mechanical hypersensitivity. 1/2

Nociceptor activity induces nonionotropic NMDA receptor signaling to enable spinal reconsolidation...

Nonionotropic NMDA receptor signaling offers a potential treatment for chronic pain by destabilizing spinal pain memories.

science.org
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Schema formation in a neural population subspace underlies learning-to-learn in flexible sensorimotor problem-solving nature.com/articles/s41593-0…
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Peter Finnie retweeted
Mariam Aly@mariam_s_aly28 Apr 2023
How are memories transformed over time to enable anticipation of the future? With consolidation, multistep anticipation becomes more efficient but less perceptually detailed. Proud of @hannahtstoll for leading this collaboration w/ @ChrisBaldassano! psyarxiv.com/x2f7s
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From the most fabulous @z_okray, Pedro Jacob, @_Nils_Otto_ et al. They fleas dae braw things wi thir wee heids. nature.com/articles/s41586-0…
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Really honoured to have edited this special issue celebrating @Karim_Nader’s contributions to memory research. Here’s a link to my introduction to the issue: doi.org/10.1016/j.brainresbu… A short thread. 1/n – at Toronto, Ontario
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Our new paper on how predictive codes emerge over the course of learning in the hippocampus. This work was led by @thisisampm in the lab (with key contributions from @mitchdesnoo @Adam_Rams and @Neurochatter authors.elsevier.com/a/1gs6b…
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Peter Finnie retweeted
Laura Lewis@lauradata31 Mar 2023
excited to share @stephaniedwill new paper! We found we could induce CSF flow in the awake human brain, by presenting intense visual stimuli. This shows that neuronal activity can drive fluid flow, and suggests neurovascular coupling contributes! journals.plos.org/plosbiolog…
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Peter Finnie retweeted
Daniel Bendor@BendorD31 Mar 2023
Replay is the spontaneous reactivation of a memory trace, a mechanism thought to underly memory consolidation
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Check out our new paper out in @NeuroCellPress today! 🎉 Great work led by twitterless Arthur Godino and friends in the @EricJNestler lab! @SinaiBrain cell.com/neuron/fulltext/S08…
Eric J. Nestler, MD, PhD@EricJNestler7 Mar 2023
Please see our latest paper on transcriptional mechanisms of cocaine action in nucleus accumbens medium spiny neurons, focused on RXRalpha and its downstream effects on gene expression, in Neuron by Arthur Godino and others. @SinaiBrain cell.com/neuron/fulltext/S08…
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New paper day! @latimerkw & FreedmanLab shows how long-term training history impacts parietal neuronal representations. The project compares encoding in two pairs of animals during categorical decisions, but the animals differed in their training history. bit.ly/3XSWtEE
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Excited to share some new astrocyte viral tools we've been working on! A thread:
bioRxiv Neuroscience@biorxiv_neursci22 Feb 2023
A toolbox of astrocyte-specific, serotype-independent adeno-associated viral vectors using microRNA targeting sequences. biorxiv.org/cgi/content/shor… #biorxiv_neursci
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