Senior Group Leader at the Broad Institute of MIT and Harvard, co-leader of Broad // Microsoft Project Ex Vivo
Cambridge, MA
Joined November 2013
- Tweets30
- Following51
- Followers117
- Likes32
Peter Winter retweeted
Biology doesn't operate in silos, and neither should the AI representation of it. Quine is an early-stage research effort to create a multimodal world model of biology. By connecting insights across biological scales and modalities, Quine helps scientists computationally search a space far larger than intuition allows and prioritize hypotheses before they reach the lab. Experimental results provide important feedback, helping researchers sharpen future research directions. msft.it/6014acaRn
Peter Winter retweeted
Excited to share our latest preprint, introducing the hierarchical cross-entropy (HCE) loss — a simple change that consistently improves performance in atlas-scale cell type annotation models. doi.org/10.1101/2025.04.23.6…
Peter Winter retweeted
Current methods in the field are trained on atlases ranging from 1 to 100 million cells. In our newest preprint, we show that these same approaches tend to plateau in performance with pre-training datasets that are only a fraction of the size.
Peter Winter retweeted
This work is a huge collaborative effort led by co-first authors @IvyNuoLiu, @kattan_walaa, Ben Mead, @cskummerlowe, co-supervised by @peterswinter, @SriRaghavanMD, @shaleklab, with contributions from our colleagues at CDoT @broadinstitute, @ragoninstitute & @MSFTResearch! (10/n)
This one has been a long time coming! Very excited to get this highly collaborative work out. More evidence that considering cell states in conjunction with driver oncogenes needs a close look!
Excited to share our lab’s latest preprint exploring how mutations and transcriptional cell states cooperate to drive therapeutic resistance in Ph+ B cell acute lymphoblastic leukemia (Ph+ ALL)! (1/14) biorxiv.org/content/10.1101/…
Peter Winter retweeted
Excited to share our lab’s latest preprint exploring how mutations and transcriptional cell states cooperate to drive therapeutic resistance in Ph+ B cell acute lymphoblastic leukemia (Ph+ ALL)! (1/14) biorxiv.org/content/10.1101/…
Peter Winter retweeted
Happening now 9AM- 12:30PM! “Dissecting acquired resistance to KRASG12D inhibition in a mouse model of pancreatic ductal adenocarcinoma” #AACR2024 authored by our TeamLab members @Julien__Dilly, @shaleklab, S. Chugh,S. Dougan, B. Wolpin, @jonathan_nowak, @peterswinter, A. Aguirre
Peter Winter retweeted
1/5🚨 New preprint alert! Excited to share
NCLUSION: a Bayesian nonparametric framework using a sparse hierarchical Dirichlet process mixture model to jointly cluster and select marker genes!
📄biorxiv.org/content/10.1101/…
💻github.com/microsoft/Nclusio…
🌐 microsoft.github.io/Nclusion…
🧵👇
Peter Winter retweeted
Don’t miss the @CellCellPress research of #FacesOfCell Andrew Navia, “Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer” cell.com/cell/fulltext/S0092…
ALT "I hope to build on our PDAC research, specifically exploring how existing therapies perturb tumor cell RNA state and their non-malignant support structures. Ideally, this can lead to RNA state-directed therapies similar to existing genotype-directed therapies."
Peter Winter retweeted
1/ Our paper that looks at cells in human breast over the course of lactation was published in PNAS this week! A press release from MIT covers this, but read on for more details!
Paper: pnas.org/doi/10.1073/pnas.21…
MIT News: news.mit.edu/2022/study-reve…
Peter Winter retweeted
So excited that our longitudinal study of the cells in human breast milk is out this week!
1/ Our paper that looks at cells in human breast over the course of lactation was published in PNAS this week! A press release from MIT covers this, but read on for more details!
Paper: pnas.org/doi/10.1073/pnas.21…
MIT News: news.mit.edu/2022/study-reve…
Peter Winter retweeted
I am thrilled to officially announce that The Jaeger Lab is open for business at Moffitt Cancer Center in Tampa, FL! @MoffittResearch @MoffittNews
Excited for this next chapter, and ready for the opportunities and challenges ahead. Come join our team!
[email protected]
Peter Winter retweeted
We want to send a warm welcome to Dr. Alex Jaeger. The newest faculty member of @MoffittNews Department of Molecular Oncology. moffitt.org/research-science…
Peter Winter retweeted
.@valarlabs is a new startup out of @Stanford on the application of #AI to #pathology (with an early focus on treatment decisions in #PancreaticCancer).
Eric Collisson from @UCSFCancer has a great quote in this story:
valarlabs.medium.com/valar-l…
Peter Winter retweeted
I guess I can comment on this now that it’s out in the public. Tenure… Wow. They say it takes a village and it’s so true. I’m just incredibly thankful for my community. No way this happens without them.
Looking forward to this next season 🙏🏾
✅ Generous, kind, positive
✅ Brilliant, creative, dynamic
❌ A Los Angeles Lakers fan
✅ Now a tenured professor
I give you: @lorin_crawford
A generational talent. I am lucky to call him a friend.
Peter Winter retweeted
1/10 Our new paper is out today in @natBME! Read the details here!nature.com/articles/s41551-0…
Peter Winter retweeted
Read this week's Cancer Discovery #ResearchWatch Tumor Microenvironment Influences Cancer Cell Transcriptional State. bit.ly/3FlWysb
@shaleklab @peterswinter @MIT @broadinstitute @harvardmed
Peter Winter retweeted
Congratulations to Carly Zeigler, a physician–scientist in training who gave a brilliant and inspiring lecture after receiving the inaugural 2021 Stuart L. Schreiber Award in Scientific Excellence for Graduate Students!
Peter Winter retweeted
Outstanding story just published in Cell @CellCellPress from Aguirre lab @DanaFarber_Hale and Shalek lab @shaleklab about microenvironmental modulation of pancreatic cancer cell states at single cell level. A must read! doi.org/10.1016/j.cell.2021.…
Peter Winter retweeted
Now online @CellCellPress
Microenvironment drives cell state, plasticity, and drug response in #PancreaticCancer
cell.com/cell/fulltext/S0092…
Fantastic paper from Srivatsan Raghavan @shaleklab @andrewaguirremd @DanaFarber_Hale
