Knowledge manifests itself in radiant dreams that shimmer like the wild sun Views are my own https://xitter.cf/t.co/xqtVHHVI17 on 🦋
London
Joined April 2008
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I’m beyond thrilled to share that our work on using deep learning to compute excited states of molecules is out today in @ScienceMagazine! This is the first time that deep learning has accurately solved some of the hardest problems in quantum physics. science.org/doi/abs/10.1126/…
David Pfau retweeted
Not only is this idea old, I’ve seen it in department seminar. Monkeying with lipid transport is almost as old as the field itself. It didn’t exactly escape notice that the most well known risk factor for AD is a lipid/cholesterol transport molecule…
GPT-Rosalind surfaced a new lead for drug discovery: could restoring cholesterol transport protect neurons from degeneration?
DCTN1 is a gene linked to Perry syndrome, a rare neurodegenerative disorder. In mouse-brain data, disrupting it increased expression of genes involved in making cholesterol. GPT-Rosalind suggested a possible explanation: cholesterol may not be reaching where neurons need it.
That gives scientists a specific mechanism to test and, if confirmed, a direction for developing new treatments for neurodegenerative disorders.
With @perturbai_tx and @scrippsresearch, a team of thousands of GPT-Rosalind agents worked in parallel, connecting gene-expression results from millions of mouse brain cells with scientific literature in just 32 minutes. We’re now expanding this collaboration to identify new drug targets.
openai.com/index/scaling-ai-…
David Pfau retweeted
The first step towards innovation is being a hater. Obviously not the only step. But you literally cannot innovate without first finding something and saying "this sucks".
The toxic positivity "techno-optimism" has ironically stifled a lot of innovation
David Pfau retweeted
Last month, we demonstrated high-rate alchemy: turning mercury into real, stable gold, beating CERN’s record by a factor of 10.
Last week, we enriched isotopes in the world’s most powerful plasma centrifuge, beating the Soviet record that stood for 40 years.
Now, we’re building a fusion reactor in San Francisco to achieve record power density.
David Pfau retweeted
Good find by Toby. AIs are far less capable on real world AI research tasks than ECI x METR or AI 2027 predict. Data from Google Argon (adding on to OpenAI):
Gemini 4 actual: ~15 minutes
ECI --> METR Prediction: ~360 minutes (6 hrs)
AI 2027 prediction: ~1,000 minutes (18 hrs)
David Pfau retweeted
Introducing beignet, a new neural field architecture!
beignet uses a multiresolution fourier frequency pyramid to achieve faster convergence and higher precision when solving PDEs and finding singularities.
Teaser: here is beignet at work fitting an image (super fast)!
Making it possible to do things that were previously impossible is infinitely more exciting than speeding up things that were already possible.
David Pfau retweeted
from the latest preprint on analytic prismatization by anschütz, le bras, rodrÃguez camargo, and scholze:
David Pfau retweeted
Imagine if some high school bros drew some buildings on CAD software then got all excited and declared software programmers have solved the most pressing problem of humanity: How to build more bulldings cheaply.
Actually, no need to imagine. Just read below.
What is AI really capable of in bio?
To separate hype from reality, we spent 3 months working firsthand with @AnthropicAI's internal research model to see if it could create an experimental scorpion antivenom.
Introducing Citrini Therapeutics.
citriniresearch.com/p/citrin…
I've lived here long enough to be clear-eyed about things, but I've seen the exact opposite of what's described in this article happen too - a US/Euro couple in London started a family, moved to Chicago, immediately encountered ICE raids in their daycare and moved to Amsterdam.
The internet told them Europe was a social paradise. Turns out the trains are awful, the health care isn’t free, and people can be really mean. buff.ly/5cLtnha
So, this actually makes climate change worse.
JUST IN: A California space startup has illuminated a section of desert near Mount Whitney at night, demonstrating how future satellites could deliver sunlight to Earth on demand.
Reflect Orbital conducted the October 10 test using powerful ground-based spotlights to simulate sunlight redirected from orbit by large reflective mirrors.
Working with China Lake Mountain Rescue, the company illuminated terrain across roughly three miles, allowing rescue teams to conduct nighttime searches, stretcher carries and other emergency-response exercises.
Reflect Orbital ultimately wants to deploy satellites capable of directing sunlight toward specific areas on Earth after sunset, potentially supporting emergency operations and extending electricity generation at solar farms.
The company received FCC authorization in July for its first experimental satellite, Eärendil-1, which will use an 18-meter reflector to test the concept from orbit.
The October demonstration used ground-based lighting. No orbital mirror has yet demonstrated the proposed capability.
The way that I do my work is very different than it was a year ago. But the nature of knowledge work is that it's all stuff that happens on a little screen. AI has changed very little outside those screens.
David Pfau retweeted
For far too long solar and storage systems are only accessible if you have >£8k to spare and a roof you own.
So we built Jules.
It’s a 2.5 kWh battery that plugs into a normal 3-pin socket. No electrician, no scaffolding, no hardwiring.
Add up to four 500W panels on a balcony, wall or in the garden. No space for panels? It also works battery-only. It runs itself: charges when electricity is cheap, discharges when it’s expensive, forecasts your solar production and your usage from your smart meter. Up to £330 a year off your bill. £799 outright. £199 if you fix with Fuse for 5 years. Panels £189 each. 10-year warranty. Reservations are open today, launch estimated 2027. Fuse customers get priority.
fuseenergy.com/jules-by-fuse
Meet Jules by Fuse Energy.
An intelligent energy system for your home. Plug in and autopilot does the rest.
It learns your habits, stores power, trades the excess and continuously lowers your bills.
Solar and storage is now for everyone.
Energy intelligently designed for you.
Up to £330 a year off your bills.
Reservations now open
David Pfau retweeted
trying to do deep learning science while the big labs pick off your friends one by one be like
David Pfau retweeted
Meta took down the No Kings organizing page today - the biggest day of protest this fall. They provided zero explanation. It stayed down for the entire afternoon until most of the protests were done.
Outrageous. Put this on the January investigation list.
David Pfau retweeted
TikTok is more anti free speech after the Americans bought it than when it was literally ran by the Chinese communist party
Larry Ellison’s TikTok has shut down the promotional account for Alex Gibney’s Elon Musk documentary. theverge.com/tech/1013453/ti…
