(1/12) Over a year ago, we launched a new project to explore whether the tissue microenvironment could predict cellular behaviour and whether reprogramming might unlock new therapeutic avenues. 🧬 Spatial transcriptomics provides deep insights into tissue organisation. We wanted to take this further by building a model that predicts how the tissue microenvironment rewires cells, and in silico predict how reprogramming influences the diseased microenvironment. Today, in collaboration with @Muzz_Haniffa at @sangerinstitute we’re excited to share the preprint for Mintflow, including two novel disease datasets. Link to preprint: shorturl.at/alFUO 🧵