Postdoctoral Fellow @broadinstitute Harvard-MIT PhD graduate from @mit_hst
Joined July 2019
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1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! bit.ly/redicas9
Rumya retweeted
Congratulations to @rumya_r @mircoscopy @DStrebinger @blake_lash @cyrusbiotech and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and efficacy of gene editing therapies. See Rumya’s posts for highlights.
1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! bit.ly/redicas9
Rumya retweeted
Nucleases, core components of CRISPR-based genome-editing therapies, can stimulate unwanted immune responses. Scientists have now engineered two CRISPR nucleases to mask them from the immune system, paving the way for safer, more efficient gene therapies. broad.io/Nucleases-CRISPR
ALT scissors cutting DNA
7/8 This study highlights how structural biology and immunology converge to create tailored solutions in medicine. By designing proteins that “fly under the radar” of the immune system, we’re improving safety and accessibility of cutting-edge treatments and transforming medicine.
8/8 This interdisciplinary work wouldn't have been possible without @zhangf, @mircoscopy, Indigo King, Samuel Vo, @DStrebinger, @BlakeLash1, Michael Killian, @yfsong, @lucas_nivon, Rhiannon Macrae, @cyrusbiotech and the entire team at @broadinstitute! bit.ly/redicas9
Rumya retweeted
Really exciting work on structural studies and engineering of a non-LTR retrotransposon with @maxewilkinson Rhi Macrae and @zhangf! Check out the tweetorial below
(Just kidding, one more movie)
Thank you my lovely co-authors @FrangiehChris @zhangf and Rhi Macrae
Also @bradyajohnston's #MolecularNodes Blender plugin is great. Everyone should use it. #b3d