Molecular biotechnologist who likes tinkering with biology
Cambridge, MA
Joined October 2019
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Retrotransposons are cool - but harnessing them for kilobase insertions AND seeing their molecular structure is even more exciting.
Great work led by @GraceKC
Check it out!!
Daniel Strebinger retweeted
Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease?
Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)
Exciting work from @KalliKappel - using pooled optical screening to determine sequence features that contribute to condensate formation!
If interested in this topic reach out to Kalli, who just started her lab at UCLA. She is an amazingly insightful scientist and a great person!
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out
rdcu.be/eq975
Daniel Strebinger retweeted
Introducing CondenSeq, an imaging-based high-throughput approach for characterizing protein condensates within the nuclear environment. @KalliKappel
nature.com/articles/s41592-0…
Daniel Strebinger retweeted
We're hiring! Our lab at the Ragon Institute of MGB, MIT, and Harvard is looking for a motivated postdoc with experience in developing and applying deep learning models. You'll work at the intersection of spatial transcriptomics and structural biology. #postdoc
Daniel Strebinger retweeted
1/ Thrilled to share an advancement in gene therapy from my PhD in @NatureComms! We've developed a new approach to reduce immune responses while maintaining efficiency—paving the way for safer, more effective therapies. Big thanks to @zhangf & @mircoscopy! bit.ly/redicas9
Daniel Strebinger retweeted
Help is on the way! Ready to take stem cell technologies to the next level for drug development @CReM_Boston @GSK: Global Biopharma Giant GSK and BU/BMC Announce Collaboration to Pioneer New Lung Disease Treatments bu.edu/articles/2024/collabo… @BUPulmonary @The_BMC @BUMedicine
Daniel Strebinger retweeted
Our paper on continuous mutagenesis in living cells using HACE is now out in @ScienceMagazine!
We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks.
science.org/doi/10.1126/scie…
Daniel Strebinger retweeted
covercovercovercovercovercovercovercovercovercovercover this is terrifically exciting
(Also please dw, the central dogma is still very much intact, this is just a bit of a funky spin on it)
The central dogma of molecular biology states that genetic information flows from DNA and RNA to protein, with reverse transcription converting RNA to DNA.
In the pursuit of understanding how bacteria defend themselves from viral infection, two groups have found alternative pathways to making genes from RNA that did not previously encode proteins. Learn more this week in Science: bit.ly/3ZO7tI1
Daniel Strebinger retweeted
So excited to announce that the Kappel Lab will open at @UCLA @uclachem in July 2025! We’ll combine high-throughput experiments and computation to build predictive sequence-structure-function models of RNA, proteins, and their interactions. More here: sites.google.com/view/kappel…
We’re excited to announce that five talented researchers and educators will be joining our department in the coming months! Learn more: bit.ly/welcomenewfaculty2024 @TomPFay @KalliKappel @LindertLab @petroviclab @uclaphyssci
RT @SGRodriques: Today, we are announcing Future House, a philanthropically-funded moonshot focused on building an AI Scientist. Read our b…
Daniel Strebinger retweeted
We are hiring at all levels, please share, and reach out if you are interested in our work! (thestreckerlab.org)
Excited to share DIRECTED (Delivery to Intended REcipient Cells Through Envelope Design): a programmable platform for cell-type-specific delivery. rb.gy/c3rdw
Thank you to @FrangiehChris, @mircoscopy, @GuilhemFaure, Rhiannon Macrae, @zhangf 1/7
DIRECTED is compatible with delivering many cargo types, including proteins and RNPs (e.g. Cas9-sgRNA). We show that DIRECTED allows the specific transduction of T cells or B cells in PBMCs, which are a complex mixture of different cell types, and even works in whole blood. 6/7
Daniel Strebinger retweeted
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with Autism risk genes biorxiv.org/cgi/content/shor… #bioRxiv