Neurologist physician-scientist @UniHeidelberg focusing on #SingleCell, #SystemsBiology, #NeuroGlia, #MultipleSclerosis, #progressiveMS and #Neuroimmunology
Mannheim, Germany
Joined February 2019
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This has been a wonderful journey decoding the MS lesion rim dynamics using paired transcriptomics. Big thanks to @Cels121 and @PauBadiaM for carrying this over the finish line! Great collaboration with @saezlab and happy to see this back2back with the work of @EggenBart lab.
Returning from our annual society meeting with a bunch of new ideas, great catching up with friends and colleagues. Wonderful platform talks about MS and IBM transcriptomics by team members @TimTrobisch and @SvenWischnewski - well done! dgnvirtualmeeting.org/home/d…
Thanks to all lab and division members, mentors and supporters of our research over the past years - I feel immensely proud to have met wonderful people along my path and look very much forward to tackling the scientific questions that lay in front of us! @Neuro_MA @schirmerlab
👏The MCTN congratulates Lucas Schirmer @schirmerlab @unimedizinma @MCTNeuroscience @UniHeidelberg, who received the Science Award of the German Society of Neurology at the DGN Congress currently taking place in Berlin. 👉lmy.de/xCdWv
Lucas Schirmer retweeted
👏The MCTN congratulates Lucas Schirmer @schirmerlab @unimedizinma @MCTNeuroscience @UniHeidelberg, who received the Science Award of the German Society of Neurology at the DGN Congress currently taking place in Berlin. 👉lmy.de/xCdWv
Lucas Schirmer retweeted
And, examining subcortica lesions identified niches such as perivascular spaces, the inflamed lesion rim, and the lesion core that are associated with the glial scar and a cilia-forming astrocyte subtype
@Cels121 @PauBadiaM @saezlab @Schirmerlab
nature.com/articles/s41593-0…
Lucas Schirmer retweeted
Two fantastic papers were published today in @NatureNeuro highlighting some major advances in understanding MS using spatial transcriptomics 🧬
I feel very lucky to have the chance to write a News & Views article about them! ⭐️ nature.com/articles/s41593-0…
Lucas Schirmer retweeted
Our work with @schirmerlab in multiple sclerosis (MS) is out today in @NatureNeuro. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️
nature.com/articles/s41593-0…
Lucas Schirmer retweeted
WebAtlas for visualising single cell & spatial data online is out: rdcu.be/dRsKu With @Muzz_Haniffa @BioinfoTongLI @Dave_Horsfall+co, we aimed to open up sc/spatial data to biologists & clinicians without coding experience/infrastructure. Rambling🧵on why this matters
Lucas Schirmer retweeted
Now out - WebAtlas pipeline for visualizing and processing integrated single cell and spatial transcriptomics data @naturemethods @bayraktar_lab @HaniffaLab @shazanfar @humancellatlas github.com/haniffalab/webatl… nature.com/articles/s41592-0…
Thrilled to feature our latest review on iron scavenging and myeloid cell polarization with a particular focus on multiple sclerosis and functions of iron-loaded macrophages at the rims of chronic active MS lesions. sciencedirect.com/science/ar…
Lucas Schirmer retweeted
REVIEW @TrendsImmuno @schirmerlab
Iron scavenging and myeloid cell polarization
👉doi.org/10.1016/j.it.2024.06…
Lucas Schirmer retweeted
REVIEW @TrendsImmuno @schirmerlab
Iron scavenging and myeloid cell polarization
doi.org/10.1016/j.it.2024.06…
Lucas Schirmer retweeted
Bei der akademischen Mittagspause von
@ResearchLifesci ist MCTN-Forscher Prof. Dr. Lucas Schirmer (@schirmerlab) mit seinem Vortrag "Entzündung im Nervensystem: Gene, Zellen und neue Therapien" dabei. Am 17.07.24, 13:00-13:30 Uhr in der Peterskirche in Heidelberg.
Nächsten Montag beginnt die letzte Woche der Akademischen Mittagspause 2024! @majendrusch, Kai Melde, @schirmerlab, Katharina Clemm und @VarunVenkatara2 schließen die Veranstaltungsreihen mit spannenden Vorträgen ab!
@UniHeidelberg @EMBLHeidelberg @uniklinik_hd @unimedizinma
Lucas Schirmer retweeted
Nächsten Montag beginnt die letzte Woche der Akademischen Mittagspause 2024! @majendrusch, Kai Melde, @schirmerlab, Katharina Clemm und @VarunVenkatara2 schließen die Veranstaltungsreihen mit spannenden Vorträgen ab!
@UniHeidelberg @EMBLHeidelberg @uniklinik_hd @unimedizinma
Lucas Schirmer retweeted
Very happy to see this paper out in @NAR_Open !! Congrats to @vicpaton on his first publication, and big thanks to all coauthors and @JulioSaezRod for the opportunity to co-supervise this work
Our workflow, FLOP, exploring the impact of filtering, normalization, and differential expression on functional analysis is now published in @NAR_Open. doi.org/10.1093/nar/gkae552
Lucas Schirmer retweeted
Proud of the @GlialRede+@redglial (@fernandes_lab+myself) symposium on #MultipleSclerosis from different #glial perspectives,cherry of a superb #FENS2024: #Patrick_Küry,#Mendanha_Falcao,@schirmerlab & Alana_Hoffmann (@MironLab) showed us many great actors to know+treat #MS.
Lucas Schirmer retweeted
Nature research paper: Senescent glia link mitochondrial dysfunction and lipid accumulation go.nature.com/3Kvvhrj
Lucas Schirmer retweeted
Happy to share our latest work on single nucleus and spatial transcriptomics in inclusion body myositis!
@NatureAging @Schirmerlab
nature.com/articles/s43587-0…
Lucas Schirmer retweeted
@schirmerlab @SvenWischnewski (@mctn @unimedizinma @Neuro_MA) and collaborators provide new insights into molecular changes associated with the pathogenesis of inclusion body myositis (IBM) using scRNAseq of patient muscle biopsies👉lmy.de/DmwAI
Online now!✨RESEARCH: single nuclear and spatial profiling of the progressive inflammatory muscle disease inclusion body myositis identifies a selective type two myofiber pathology @SvenWischnewski, @Schirmerlab nature.com/articles/s43587-0… rdcu.be/dJUyN
Neue Erkenntnisse und Therapieansätze bei entzündlichen Muskelerkrankungen nachrichten.idw-online.de/20…
Excited to share our work on cell type mapping of inflammatory muscle diseases highlighting a selective vulnerability of type 2 fibers in inclusion body myositis with data about potential new drug targets. @SvenWischnewski @Tlloyd4_jhmi nature.com/articles/s43587-0…