@sevan_belian

PhD student at Institut Pasteur, working on the mecanism of formation of tunnel in nanotubes.

 Paris, France
Joined March 2023
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Link of the articles Reviews: oaepublish.com/articles/evcn… journals.biologists.com/jcs/… Research article: embopress.org/doi/full/10.15…

Hijacking intercellular trafficking for the spread of protein aggregates in neurodegenerative...

Over the years, the influence of secretory mechanisms on intercellular communication has been extensively studied. In the central nervous system (CNS), both trans-synaptic (neurotransmitter-based)...

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This year is coming to an end, filled with science, inspiring people, discussions and events. The year of my first publications, two reviews and one research article, published in JCS, EVCNA and The EMBO Journal. Thanks to everyone that made this possible, and happy new year !
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In this paper, we review the spread of neurodegenerative pathologies, with a special emphasis on tunneling nanotubes (TNTs).
Extracellular Vesicles & Circulating Nucleic Acids@VesiclesAcids9 Mar 2023
New review - Hijacking #intercellulartrafficking for the spread of protein aggregates in #neurodegenerative diseases: a focus on #tunneling #nanotubes (TNTs) from @_ranabir and Professor #ChiaraZurzolo of @univ_paris_cite @UnivParisSaclay @UninaIT evcna.com/article/view/5498
TNTs facilitate the transfer of NDs-causing protein aggregates. A: Unhealthy cells containing protein aggregates can form TNTs with a naïve, healthy cell, eventually spreading aggregates such as PrPSc (Prion’s disease), Tau and Amyloid-β (AD), α-Syn fibrils (PD), and mHtt (HD). B: Such transfers can happen between the same type of cells via homotypic TNTs (left panels), or between different cell types via heterotypic TNTs (right panels).

ALT TNTs facilitate the transfer of NDs-causing protein aggregates. A: Unhealthy cells containing protein aggregates can form TNTs with a naïve, healthy cell, eventually spreading aggregates such as PrPSc (Prion’s disease), Tau and Amyloid-β (AD), α-Syn fibrils (PD), and mHtt (HD). B: Such transfers can happen between the same type of cells via homotypic TNTs (left panels), or between different cell types via heterotypic TNTs (right panels).

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