@therealKCGS

188 inhibitors across 210 #kinases. A product of #openscience, inspiring the discovery of pioneer medicines

 Chapel Hill, NC
theKCGS.com
Joined May 2015
  • Tweets658
  • Following141
  • Followers343
79Media
A collaboration with UNC virologists using @therealKCGS led to this —> uncnews.unc.edu/2022/05/20/u…
Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2 biorxiv.org/content/10.1101/…

Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2

Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human and murine β-coronaviruses (β-CoV)....

biorxiv.org
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An ATP-competitive kinase inhibitor with exquisite selectivity. How? Read on....⁦@thesgconline⁩ ⁦@DruggableGenome⁩ pubs.acs.org/doi/10.1021/acs…

A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique...

Abstract. STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However,

pubs.acs.org
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Best Kinase Inhibitor Set. Ever. retweeted
aled edwards@aledmedwards10 Nov 2020
Cheryl announcing #Target2035 webinar series at today’s kick-off meeting. Looks exciting! ⁦@CherylArrowsmi1⁩
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Meet the talented Alison Axtman from our team @UNC @thesgconline pubs.acs.org/doi/10.1021/acs…

NeuroChat with Research Assistant Professor Alison Axtman

The NeuroChat series continues with a great Q&A from Research Assistant Professor Alison Axtman from the University of North Carolina at Chapel Hill (U

pubs.acs.org
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With our friends at Promega we built the first map of CDK drug selectivity in live cells across the whole family: CDK1-20 #openscience #chemogenomics nature.com/articles/s41467-0…
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Best Kinase Inhibitor Set. Ever. retweeted
aled edwards@aledmedwards5 Apr 2020
A group of us around the world are creating an #openscience non-profit to invent drugs explicitly to put on the shelf for the next pandemic. We started the project last summer, but should have started a decade ago…damn. Announcement this week or next. @thesgconline
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Best Kinase Inhibitor Set. Ever. retweeted
The University of North Carolina at Chapel Hill@UNC16 Mar 2020
Researchers at @UNCpublichealth are testing an antiviral drug that shows promise as a possible treatment for COVID-19. #UNC’s Ralph Baric heads the lab developing the broad-spectrum antiviral that could potentially provide relief to the global pandemic unc.live/2ISOsM0

Coronavirus drug shows promise at Carolina | UNC-Chapel Hill

[Video by @UNCResearch] UNC Gillings School of Global Public Health researchers are testing a new broad-spectrum antiviral drug that could potentially be a relief to the global coronavirus pandemic.

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Round table discussion at PharmSci 2020 about the social and economic impact of #openscience @UNCPharmacy
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Best Kinase Inhibitor Set. Ever. retweeted
Ximbio@Ximbio2 Mar 2020
Discover a new #Kinase Chemogenomic Set from @therealKCGS ximbio.com/reagent/157681/th… #datasheet #lifesciences #reagents #inhibitors
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Best Kinase Inhibitor Set. Ever. retweeted
The Mark Foundation for Cancer Research
@TheMarkFdn28 Feb 2020
Proud to announce today an expansion of our partnership with @ChordomaFDN to accelerate drug discovery in an open-source way! CC: @dhdrewry @UNCPharmacy @ICR_London @PaulWorkmanICR @thesgconline chordomafoundation.org/lates…
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Best Kinase Inhibitor Set. Ever. retweeted
Chordoma Foundation
@ChordomaFDN28 Feb 2020
Together with @TheMarkFdn, we are proud to announce a two-year, $1.4M grant to researchers @PaulWorkmanICR @dhdrewry @Ogileadi focused on creating the first drugs capable of targeting #brachyury, the Achilles’ heel of #chordoma chordomafoundation.org/lates…
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Want to learn how #openscience will lead to affordable medicines? Come to the #pharmsci2020 symposium @UNCPharmacy in Chapel Hill on Tuesday #SGC-UNC #drugdiscovery wraltechwire.com/2020/02/27/…
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Best Kinase Inhibitor Set. Ever. retweeted
Dr. Arij Al Chawaf@ArijAlChawaf25 Feb 2020
ICYMI: Check out the Kinase Chemogenomics Set (KCGS): 187 inhibitors for 215 kinases. A collaborative resource meticulously developed & curated by the SGC-UNC team. thekcgs.com/ More details here on @biorxivpreprint biorxiv.org/content/10.1101/… #openscience
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[Part 2] ...This collaboration has resulted in multiple publications and grant funding as a specific result of these interactions. - Lee Graves, PhD, Professor in Department of Pharmacology @UNC_SOM Read more about Dr. Graves and his KCGS Collaboration --> theKCGS.com
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[Part 1] My lab and I have greatly benefited from using KCGS in investigating cellular mechanisms of drug resistance in cancer by the application of chemogenomic libraries to discover novel kinase targets for pancreatic cancer treatment...
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We are proud to work with @boehringerus and their #OpnMe platform to encourage open collaboration between scientists! Check out the work they do at OpnMe.com and become a part of the KCGS open science community at theKCGS.com!
Boehringer Ingelheim
@boehringerus18 Feb 2020
We are proud to contribute to @therealKCGS’s #openinnovation initiative by donating 17 kinase inhibitors to their Kinase Chemogenomics Set. Learn more on #opnMe: bit.ly/2ShIw4N
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We are grateful for the collaboration we share with @Boehringer and the #opnMe team!
Boehringer Ingelheim
@Boehringer17 Feb 2020
We are proud to have donated 17 kinase inhibitors to the #OpenInnovation initiative Kinase Chemogenomics Set. Kudos to @therealKCGS from the #opnMe team

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Thanks to @UNCPharmacy for helping make #KCGS available to the world
UNC Pharmacy@UNCPharmacy13 Feb 2020
#DYK: the first Structural Genomics Consortium lab to operate in the US is located in #UNCPharmacy? Thanks to support from the Eshelman Institute for Innovation, Tim Willson & his team's research is placed in the public domain for use, no strings attached bit.ly/2tOTGo5
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Best Kinase Inhibitor Set. Ever. retweeted
UNC Pharmacy@UNCPharmacy13 Feb 2020
#DYK: the first Structural Genomics Consortium lab to operate in the US is located in #UNCPharmacy? Thanks to support from the Eshelman Institute for Innovation, Tim Willson & his team's research is placed in the public domain for use, no strings attached bit.ly/2tOTGo5
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