@therealRYC

PGY-4 @UW Psychiatry. Prev MD-PhD @WUSTL. Biomarker and drug discovery for psychiatry, starting with Schizophrenia. Dog Daddy x2 to Taro and Azuki.

 Seattle, WA
Joined February 2020
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1.1KMedia

Who Started It? The Physics of Why Relationships Get Stuck

“I only nag because he shuts down.”

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The Muscarinic Bet, Two Years On

Last week, MapLight Therapeutics announced that its muscarinic agonist ML-007C-MA met the primary endpoint of its Phase 2 trial in schizophrenia. Patients on the twice-daily dose improved by 11.7 poin…

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The Professional Patient: Why Psychiatric Drug Trials Keep Failing

There's a secret hiding in plain sight in drug discovery in psychiatry.

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The Only Article You Need to Be Informed on SSRIs in Pregnancy

A 2025 FDA advisory panel reviewed SSRI safety in pregnancy. ACOG issued a statement. SMFM issued a statement. Commentators took sides. Social media caught fire.

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Why You Think You Have ADHD

Your coworker just got diagnosed. Your college roommate swears she's had it all along. Your partner watched a TikTok and now he's "pretty sure" he has it too.

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Interpreting Psychedelic Trial Readouts Like a Psychiatrist

Helus Pharma ($HELP, formerly known as Cybin but rebranded due to avoiding a pure "psychedelic" association) dropped topline data this week from the Phase 2 signal-detection study of HLP004, their deu…

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How to Disagree Productively in the Age of Polarization

Society has become polarized.

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Will GLP-1s Treat Alzheimer's Disease?

In just two weeks (December 3 at 5:05 pm PST), @novonordisk will be revealing results from the evoke and evoke+ trials, what the company has called its "lottery ticket" to clawing back its fumbled mar…

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Ketamine in a Bit of a Hole

This week, a bombshell paper published in JAMA Psychiatry found Ketamine no more effective than a benzodiazepine in treating depression. Why then, are ketamine and its enantiomeric cousin esketamine s…

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Is There a Brain Signature of Mental Illness?

If mental health stems for the brain, where is the smoking gun? Unlike neurological disorders where a single lesion can lead to crippling deficits that can be reliably mapped back to a specific area o…

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A Revisionist History of the DSM-5

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) does not have many friends. Psychiatrists view it as a lumbering, imperfect, laundry list of symptoms clustered into ar…

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This Week in Psychiatry - Ep. 9

Welcome back to This Week in Psychiatry!

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