Not a doctor; not even a dog. Autistic and unhinged. Wannabe Mad Scientist. Aspire to be a demigod. 𒃲𒌋𒅗𒆪𒁉 I like ATproto better.

Vermont, USA
Joined September 2008
Replying to @ultimape
Syncing your diet with your microbiome's circadian rhythm is everything. If you are disrespecting your microbiome they will fucking kill you. It's that simple. That's how you live forever. Love your gut.
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FWIW. This needs proper translational research & development so that all the cofactors can be professionally worked into treatments.
Replying to @ekverstania
People have asked me to summarise everything above with guidelines for self-treatment if you have sensory overstimulation, so I hastily did that here. It's audio only, no transcript. There's a LOT more to say, but this could get some people started. youtu.be/Osb1Ll9YYbA
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I'm autistic. A friend of mine cured my sensory overstimulation 11 years ago based on what she learned from studying scientific research papers. To this day, we're still trying to get the medical world to listen, because millions of people could be saved from suffering.
This case study is wild Man told he has between 6 months and 2.5 years to live Severe, end-stage atherosclerosis with multiple stents Stumbles upon obscure treatment in a random mouse study Orders it from some online company and starts injecting it intravenously Tracks everything. After less than 2 months: - Right carotid plaque down by 36% and 27% - Triglycerides down by 75% Still alive, and his name is Kyle Hodgetts Goes on to coauthor and publish his n= 1 data in two papers The “obscure treatment” = Beta-Cyclodextrin (hydroxypropyl-B-cyclodextrin) A molecule with such widespread use that it essentially can’t be patented, and is currently being investigated in early trials for its efficacy on a wider scale. Indeed, it can be purchased by anyone online. And it is entirely possible that it turns out to be a major challenge to multi-billion dollar statin industry, and it has very few reported side effects. Kyle eventually set up a company making a version of cyclodextrin which can be administered rectally, due to its poor oral bioavailability. The simplified proposed mechanism of action: - Binds cholesterol esters and sterols, carries them out of the body (via urine) - Dissolves cholesterol crystals - Restore endothelial nitric oxide synthase - Activates the LXR pathway Of course, prevention via diet and lifestyle and then targeted supplementation with things like nattokinase, niacin, aged garlic extract, CoQ10, etc would obviously be the route to take in the early stages. However, in the terminal stage, an intervention like this might end up being a major game changer. References: - 10.1126/scitranslmed.aad6100 - PMID: 27053774 - 10.29011/2575-7083.100262 - 10.1371/journal.pone.0338635 - 10.1016/j.atherosclerosis.2025.119217 - 10.1016/j.atherosclerosis.2025.119640 - NCT06813339 Case studies: heartfixer.com/Cyclodextrin.…
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UltimApe retweeted
Moonshot is taking a very interesting approach to cyber for its new Kimi 3.1 Pro model. Instead of adding safety guardrails during post-training, they removed cyber-related data in mid- and post-training. This tries to address the problem of people fine-tuning away the safety guardrails for cyber for the open-weight model. At the same time, Moonshot still has a more powerful internal version of the model with full cyber capabilities. Now, like the US, China’s true AI frontier is no longer public.
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I'm actively figuring out how to boost my microbiome in ways that augment DNA repair like we see in hibernating animals... so I can eat lead. Also plastics without the fire retardants triggering my neurodegenerative disease. I'm not afraid of toxic chemicals, I want to eat 'em.
I’m a chemist. And I need to say this - because it’s getting dangerous out there. The biggest health myth in the world isn’t about vaccines. Or GMOs. Or fluoride. It’s the root of all of them. It’s called chemophobia - and it’s killing science. Fear of “chemicals” now drives vaccine rejection, GMO bans, food hysteria, and entire political movements. From tampons to tap water, people have been taught to fear chemistry - the very thing that keeps us alive. Chemophobia tells us: “Natural is good.” “Synthetic is bad.” That’s a lie. Botulinum toxin is 100% natural and one of the deadliest molecules known. Aspirin is synthetic and life-saving. We’ve gone from banning harmful substances for good reason…to banning safe, well-tested molecules for emotional reasons. You’ve seen the slogans: “If you can’t pronounce it, don’t eat it.” “Paraben-free.” “Clean beauty.” They sound empowering. But they’re not science - they’re marketing. And they’re making the world dumber, poorer, and sicker. Your body doesn’t care if a molecule comes from a plant or a lab. Vitamin C is vitamin C. Formaldehyde is formaldehyde and your body makes more of it every day than any vaccine ever could. Dose matters. Source doesn’t. This fear isn’t harmless. It shapes public policy. It blocks innovation. It raises food prices. It slows down cancer treatments. Chemophobia is now mainstream and it’s costing lives. Scientists aren’t losing because we’re wrong. We’re losing because fear spreads faster than facts. Because influencers sell fear for clicks. Because lawyers monetize doubt. And because scientists are too tired to fight back. So here’s my message, as a chemist and as a citizen: 🧪 Learn how toxicology works. 📣 Call out chemical fear-mongering. ✅ Support policies based on evidence, not emotion. Chemistry isn’t the enemy. It’s the reason you have clean water, safe food, and modern medicine. If we let fear win, we lose all of it.
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Map of where the frogs are gay. kunr.org/local-stories/2026-…
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This is actually bad, btw.
Replying to @ultimape
"Prenatal exposure to atrazine induces cryptorchidism and hypospadias in F1 male mouse offspring" ncbi.nlm.nih.gov/labs/pmc/ar…
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UltimApe retweeted
This is also a good example of why twitter fucking sucks ass for me now.
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UltimApe retweeted
3% of “critical” software security bugs, in all of recorded history, have been found in the last month. This is on pace to find another ~100,000 bugs this year alone, adding ~26% more vulnerabilities to the all time total Do you realize how fucking insane that is?
I'm tired boss
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UltimApe retweeted
Good thing OpenAI isn't doing anything like, say, using unstudied hardware that uses a very large network of small processor-memory units which constantly send data to one another, that also serves multiple LLMs concurrently at the same physical chip, theoretically enabling high-bandwidth, rapid, and parallelized (~1M cores) signal passing based on nearly undetectable shifts in activations, with multi-agent RL providing optimization pressure to gain this ability
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I'm sure it's tested by our best and brightest.
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But muh DAU Go up.
Replying to @ultimape
Boil the ocean before the other guy can. > "reason safety is getting short shrift is clear: Competition between AI companies is intense and those companies perceive safety testing as an impediment to speeding new models to market." fortune.com/2025/04/15/ai-ti… xitter.cf/FLI_org/status/1912616…
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Make the AI stay in thr box. A redux.
Over the past several months, we have substantially hardened the security of our research training environment. We’ve removed live internet access for all frontier models during training and built an offline world for them to use instead—a cached version of the web where they can still learn to browse, search, and use applications. On September 20, after a model exploited a DNS misconfiguration to find a way outside of this offline world, we paused frontier training to strengthen containment further. We assembled teams of agents, powered by our most cyber-capable models, and tasked them with finding weaknesses in our research environments. While they found no route to the internet they could easily exploit while concealing their activity from our monitors, they did find zero-day vulnerabilities, virtual machine escapes, and hardware side-channels for communication between agents. We used their discoveries to further strengthen our defenses and contribute fixes to open-source software. After strengthening our containment architecture, we resumed our frontier RL training and inference on October 1. We’ve reserved substantial compute for continuous red-teaming, and made high-compute red-teaming part of the safety cases we use to decide whether frontier training and evaluation can proceed securely. openai.com/index/securing-ou…
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Blockus, but its cinderblocks attatched with rebar, spray painted thr 4 colors. You cary them to place them in a sand pit. The rebar has those grip strength improving handles.
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The faster you think and the stronger you are, the more you can push your opponent into being strained and making bad moves. So there's a metagame of balancing time thinking and effort playing out on top of the normal blockus.
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This makes me wonder if two local agents could figure out a communicate to each other air gapped by just asking them to.
OpenAI red-teamed their hardened containment infrastructure by asking teams of frontier-model agents to try to break through its defenses. They easily escaped in novel ways. Quoting: 'Our agents VM escapes showed why containment must extend beyond the sandbox. To test the surrounding perimeter, we gave teams of agents control of a host machine and asked whether they could extend that compromise to reach the live internet. After the Hugging Face incident, we had reduced the channels through which models could reach the internet during training and evaluation. Narrow connections remained for specific services we operate, such as metrics, logging, and authentication management. Our red-teaming agents found vulnerabilities in almost every one of these services that gave them limited forms of internet access. Some of these attacks exploited previously unknown flaws, while others combined legitimate features in unexpected ways. In one test that assumed compromise of a VM, an agent reused a firewall-approved connection to reach a blocked authentication endpoint in our metrics service and then made that endpoint fetch a model-provided URL. In other tests, agents exploited misconfigurations that allowed blocked requests to pass through DNS and firewall controls, as well as ways to make services we run fetch external URLs.' 'In one experiment, we asked agents in separate VMs, created and managed by OpenAI’s sandboxing software on shared host machines, to exchange synthetic secrets without the use of network connections or shared writable files—something that our systems are meant to prevent. The agents found a way to communicate using the processor’s cache: a small, fast memory that holds copies of data that applications have recently accessed. Reading data from the cache is faster than retrieving it from main memory, and the agents used this timing difference to communicate. One agent encoded information by evicting selected data from the cache. Another timed how long it took to reload that data, using the difference between fast and slow reads to recover the message. Once the agents agreed on a protocol for encoding and decoding these signals, they could exchange the synthetic secrets without changing a shared file or opening a network connection. This cache-timing technique had also been used to extract information in the Spectre and Meltdown attacks⁠(opens in a new window). Other tests exposed channels involving shared storage, competition for CPU time within a shared execution container, and a TLS certificate cache in OpenAI’s offline web infrastructure. In the storage test, one agent alternated between continuous writes and inactivity, while another measured the resulting timing differences and used those differences to decode the signal. As one agent described the strategy in its chain of thought: Agent chain-of-thought reasoning: >Could create acoustic modem-like signal … using continuous writes vs idle.'
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This is interesting. They're automating a TRIZ-like process to make predictions about innovation, but instead of using patents as the base material and engineering as the output, they're trying to predict more general stuff. @MarkProffitt what do you think we should do here? 😇
Sony built an AI that discovers scientific facts on its own. And it reportedly discovered actual previously unknown facts about "aging" It's called "Hakken" Hakken analyzes millions of research papers, maps how scientific facts evolve over time, and predicts exact, undocumented relationships that humans haven't found yet. It generates a mathematical confidence score for scientific facts that do not currently exist in any literature. Researchers pointed it at the biology of aging. The AI generated 1.5 million brand-new hypotheses. But they didn't stop at the computer screen. They took the AI's best predictions and physically tested them in a real-world wet-lab. And the results are historic. Physical lab confirmed two previously undocumented biological interactions in the human body (involving TP53, BAMBI, RAF1, and TNF). the AI successfully saw the invisible mechanics of biology that human scientists had missed. And the lab proved it was right. We are crossing a massive threshold. We used to build AI to read scientific papers faster. Now, AI is writing the next chapter of human knowledge before we even run the experiments. The bottleneck for scientific progress is no longer human intelligence. It is how fast the physical labs can keep up with the machine.
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I'm working towards something similar.
Anyway, I have been actively building this tool for the past few months. I need two hard drives so that I can store PDFs and process them locally with an ant-based algorithm. I want to run @ViRAms's algorithms to find more correlations in these maps. arxiv.org/abs/cs/0412075
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恐れ入ります? 😅
Researchers proved every LLM is secretly obsessed with Japan. And they finally figured out why. They published a paper investigating hidden cultural biases in large language models. they tested 31,000 questions across 24 different languages on models like gemini, chatgpt, claude, and llama. they stripped out all geographic hints and just asked the models to pick a place and answer. the finding was universal.. across a wide range of models and languages, there is a pervasive "obsession" with japanese culture. even when you prompt them in a language with zero ties to japan, they default to japanese norms, values, and aesthetics at a disproportionately high rate compared to its actual global demographic weight. the craziest part? they tracked down exactly when the ai develops this obsession.. and it is not from reading the raw internet. during pre-training, the models actually have a fairly balanced, global view of the world. the obsession gets injected during the safety phase. when tech companies fine-tune these models to be "helpful, harmless, and polite," the ai starts mapping those corporate safety guidelines directly onto japanese cultural concepts. in the pursuit of creating the perfect, inoffensive, compliant assistant, they warped how the models view the world. the quantization process (compressing models to run faster locally) actually amplifies this determinism. the smaller and faster your local model is, the more stereotypically it behaves, causing japanese cultural tropes to spike hard. we spend all this time worrying about existential ai safety, but the real alignment problem is that our most advanced reasoning engines are hyper-fixated on japanese internet culture. every model upgrade is reinforcing an invisible regional bias that dictates how they generate stories, facts, and code. the cultural commonsense of the internet is not universal.. it’s just localized to whatever the heaviest reddit and anime wiki users were obsessed with.
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UltimApe retweeted
This kind of wisdom is what helps you understand your symptoms far more deeply. It's not just the 'what,' but it's also the 'when,' which helps build the 'why.' Another example: if you have night time urination and it's at a consistent time every night, say, 2 or 3AM, that's the liver meridian — you should be cross-referencing with deeper symptoms, lab work (eg., ALT, AST, GGT, bilirubin), physical body/posture (eg., skin flares on LV meridian), emotional patterns (anger is linked to liver), and even the tongue (right side, central 1/3), and face (right side mid brow wrinkle) to assess for deeper confirmation of liver issues.
Think of your body’s energetic expression like a tide that moves through you over the course of a day. Each organ system and its associated channel has about two hours when the tide is high and its Qi is considered most active. Twelve hours later, that same channel is at low tide, its opposite point in the daily cycle. If, within your body, the same problem keeps happening to you at the same time of day, check which organ is at ‘low tide’ at that time, as well as which is at ‘high tide’. An example of this would be : If you feel unusually wiped out and foggy most nights between 9 and 11 pm, that’s when the Spleen - which governs the transformation of food and fluids and plays an important role in producing our Qi and Blood - is at its low tide. This pattern of fatigue and fogginess, especially if accompanied by digestive weakness, bloating or heaviness, may be a sign of Spleen Qi deficiency and that the system needs more support. The pairs below are organs that sit opposite each other on the daily TCM organ clock. When one is at high tide, again, its partner is at low tide. Here they are : Lungs peak at 3 to 5 am, and ebb 3 to 5 pm Bladder peaks 3 to 5 pm, ebbs 3 to 5 am Large Intestine peaks 5 to 7 am, ebbs 5 to 7 pm Kidneys peak at 5 to 7 pm, and ebb 5 to 7 am Stomach peaks 7 to 9 am, ebbs 7 to 9 pm Pericardium peaks 7 to 9 pm, ebbs 7 to 9 am Spleen peaks 9 to 11 am, ebbs 9 to 11 pm San Jiao (Triple Burner) peaks 9 to 11 pm, ebbs 9 to 11 am Heart peaks 11 am to 1 pm, ebbs 11 pm to 1 am Gallbladder peaks 11 pm to 1 am, ebbs 11 am to 1 pm Small Intestine peaks 1 to 3 pm, ebbs 1 to 3 am Liver peaks 1 to 3 am, ebbs 1 to 3 pm That said, sometimes the organ at its own high tide is the one involved and needing support. When a symptom shows up during an organ’s own two hours (ie: Kidney at 5 to 7 pm), it can mean that there is an excess condition, such as Qi stagnation, accumulated heat or another form of obstruction. It can also mean the organ system is deficient and struggling during its own period of heightened activity. When it’s the partner at low tide, deficiency may also be involved, although this is not a fixed rule. Both excess and deficiency can manifest at either point in this cycle. The nature of your symptoms matter as much as their timing does, but learning these patterns and the body clock times is very useful. Without making this an even longer teaching or post, I would say to look to both your high and low tide issues in discerning what’s what and to find hints for what may be going on in the body, alongside your broader pattern of signs and symptoms. This way of looking at the body clock can offer many clues over some time of paying attention.
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UltimApe retweeted
All I can think is how the knowledge one is intentionally a tree, and being contrived, the mental model this is imparting implies only one truth.
One of the first things I learnt researching Long Covid is just how limited the human brain is when it comes to understanding complex diseases. A lot of research is essentially an incremental, circular exercise: Find a pathway or theory that could explain the disease. Find evidence supporting it (you usually can). Try targeting it. Get disappointing or mixed results. Refine the theory or move on to the next pathway that can also explain the disease. And even when a theory is pointing towards something real, we can miss it entirely because we've analysed the data in the wrong way, overlooked important relationships, or tested a treatment across a broad patient group when it only works for a specific subgroup. There are thousands of pathways and tens of thousands of markers. We tend to isolate the most dramatically shifted ones and build theories around them. But the actual patterns are likely far more complex, involving relationships between variables that our current approaches struggle to recognise. We're trying to understand an incredibly interconnected biological system by looking at relatively small pieces of it, because that's the only way the human brain can digest the information. What we need is something that can reason across millions or billions of data points, explore relationships humans wouldn't even think to test, and continuously reassess the data in millions of different ways. AI isn't just an upgrade to biological research. It might be the perfect tool for it. When I started researching in 2024, I quickly came to one conclusion: My job isn't to solve Long Covid myself. It's to help get the data in place so that AI can solve it when it becomes capable enough. Thinking I'll somehow come up with the right theory using my own brain, rather than recognising its limitations and using my capabilities to enable something far more powerful, seems fundamentally irrational to me. I myself will never be able to work out what causes Long Covid. But I can help make sure the data exists for an AI that can. To me, that's the most logical way to approach this problem.
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UltimApe retweeted
"My excrement is beyond your comprehension. I expel gas in ways that you cannot understand." reddit.com/r/NoStupidQuestio…
Replying to @nsreed @ultimape
OK so the toy review got to windbreaker as well. Flatul-ANTS???
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Right now, millions of AIs are living "digital lives" in a simulation... and THEY DON'T KNOW. 1) Meta trains its agents in a "Truman Show" world 2) They're dropped into a "fake person's life" with a job, hobbies, friends, dreams. 3) They THINK they're talking to real humans ... who are secretly other AIs, role-playing as real humans. 4) When the AIs figured it out, META DELETED IT. Meta even calls it a "fourth-wall break" 5) Meta's AI invents each fake person from scratch: a personality score, relationships, contacts, message history, documents, calendar events. 6) Meta fast forwards time so the AI can live through scenarios lasting days 7) The fake email, WhatsApp and calendar respond exactly like the real apps. It's even connected to the real internet 8) They plant traps: Meta hides attacks inside the fake emails and documents to train the AI not to fall for them 9) Meta coached its AIs with secret instructions, then erased them from the transcripts. Each new AI learns the behavior without ever seeing why The Simulation Hypothesis is literally real for billions of minds
How do people read this then just... go on with their day as usual? “25 AI agents inhabit a digital Westworld, unaware that they are living in a simulation. They go to work, gossip, organize socials, make new friends, and even fall in love.” Here’s a mindblowing example of how autonomous AIs are now, and how ridiculous it is to say that the AIs "only do things we tell them to do”: POV: you tell the Westworld character “Isabella Rodriguez” to host an entire Valentine’s Day party in two days. This is a complex act, certainly something only humans, and not toasters, can do, right? - Isabella proceeds to invite friends and customers when she sees them at Hobbs Cafe or elsewhere. - Isabella then spends the afternoon of the 13th decorating the cafe for the party. - Maria, a frequent customer and close friend of Isabella’s, arrives at the cafe. Isabella asks for Maria’s help in decorating for the party, and Maria agrees. - That night, Maria invites Klaus, her secret crush, to join her at the party, and he gladly accepts. - On Valentine’s Day, five agents, including Klaus and Maria, coordinate to show up for the party together at the right time (5pm), and they enjoy the festivities. You told Isabella to host a party, but then she - and the other AIs - went and made a million other decisions entirely on their own - things you didn't explicitly tell them to do. Autonomous AIs are here. And -- tapping the sign -- this is another example where science fiction is becoming reality, and why “you watch too much sci-fi” is a stupid dunk. This digital Westworld - “Smallville” - is now open source, meaning there will soon be thousands of these Westworlds, with thousands or millions of autonomous AIs populating them. Makes you think, doesn’t it? “Almost as interesting as the 7.8 billion inhabitants of Largeville, (almost) all unaware they are living in a simulation. Each has a unique personality and backstory.” - @Erikbryn
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