Dietary and gut microbiota interventions matter for restoring the gut barrier Timmie A. Britton & Prof. @mgrover_gi update the role of the gut barrier in disorders of gut-brain interaction and interventions to improve it: 👉 Microbial dysbiosis from diet, disease, or antibiotics can leave the intestinal lining exposed to pathogens 👉 Using a simplified, less restrictive low-FODMAP diet might be prudent for improving gut barrier function mainly in IBS, but some evidence shows benefits in functional dyspepsia 👉 Complex dietary fiber blends support gut barrier function by serving as important energy substrates for select bacterial commensals that ferment them into short-chain fatty acids 👉 Glutamine and other amino acids shape enteric immunity, mucus production, and gut microbiota profiles 💡 Rather than expecting that one single nutrient or diet will improve gut barrier function, think of broad dietary patterns that are mostly plant-based and reduce saturated fatty acids 📚 Read more via @LancetGastroHep : thelancet.com/journals/langa…

What if the microbiome of fermented foods explains their potential health benefits❓ Fermentation supplies us with probiotics, prebiotic substrates, and postbiotic metabolites that can influence: 🔸the oral and gut microbiota 🔸immune function 🔸metabolism A hot-off-the-press review in @NatureRevMicro updates the knowns and unknowns of the fermented foods microbiome: ✅ The fermented food microbiome affects the oral–gut axis via transient microbial exposure and metabolites ✅ Compared to dairy-based fermented foods, fermented vegetables such (e.g., kimchi, sauerkraut and tempeh) are characterized by a great diversity of microorganisms and functions ✅ The fermented food microbiome may help to suppress pathogens, promoting the microbial community and suppressing inflammation Not all fermented foods available in the supermarket are a true source of #probiotics Scientists are beginning to understand the role of their live beneficial microbes in human health beyond the gut nature.com/articles/s41579-0…

‼️Not all dietary fiber sources are the same for lowering #Crohnsdisease risk 💡@The_GEMProject followed up healthy people with high risk of Crohn's for 8.5 years and found ⬆️ ß-glucan and inulin intake were associated with: 🔸Preserved gut barrier function 🔸⬇️ inflammation 🔸⬇️ CD risk When looking at 94 first-degree relatives (parents, siblings or children) who went on to develop the disease themselves from a pool of 3,314 individuals over a median of 8.5 years: ✅ ⬆️ beta-glucan (found in oats, barley, grains) and inulin (found in garlic, onions, leeks, asparagus) intake was protective of subsequent Crohn’s, each associated with around a 30% reduction in risk ✅ ⬆️ beta-glucan and inulin intakes were linked to: 🔸A ⬇️ in Ruminococcus torques, a species previously identified as the highest contributor to GEM Crohn’s disease microbiome risk 🔸⬇️ C-reactive protein (but not with changes in fecal calprotectin) 🔸⬇️ gut permeability ✅ ⬇️ intake of pectin, inulin, FOS, and beta-glucan was linked to impaired intestinal permeability and subclinical inflammation, while ⬇️ inulin intake was associated with ⬆️ fecal calprotectin levels 🌾🧅Don't underestimate the power of fermentable dietary fiber to reduce the risk of #Crohns among first-degree relatives of patients with the condition @AGA_Gastro 📚Read more: gastrojournal.org/article/S0… 🔍Editorial from @PaedsRH: gastrojournal.org/article/S0…

Patients usually find the dietary management of ulcerative colitis after surgery challenging @EmmaHalmos, @yao_ck & colleagues explored patients' interests in TikTok Patients created videos to connect with other patients and were interested in: 1️⃣Adaptive dietary progression in the post-surgical period 💡Restriction of fiber isn't an evidence-based practice, both during IBD flares and during the post-surgical recovery period 2️⃣ Personalization of diet 👩‍⚕️There's no one-size-fits-all diet and it's important to nuance dietary advice based on disease stage and patient preferences 3️⃣ Emotional and social impact of dietary restrictions and modifications ⚠️The narrowing of “safe foods” may restrict not only diet but also fundamental social activities Patients with ulcerative colitis need reliable online dietary resources that address the holistic burden of post-operative dietary modifications and help them live a fulfilling life 📚Read the full research here: mdpi.com/2072-6643/18/7/1110