PI@BIG, Chinese Academy of Sciences. Former computational biologist @broadinstitute, working on the genetics of human cardiovascular diseases. View on my own.
Joined October 2019
- Tweets263
- Following372
- Followers201
- Likes2.1K
Great opportunity 👍👍
🚀 Open postdoc position!
If you're a driven scientist with a strong interest in human genetics related to cardiovascular disease and want to advance genetic discoveries, therapeutic hypotheses, and precision medicine for CVD, I hope you apply! broadinstitute.avature.net/e…
Wallace Wang retweeted
🧬 Calling all GWAS + integrative analysis researchers!
🔎 Come explore the PEGASUS Framework, a FAIR community standard for predicted effector genes, at our Knowledge Portal Webinar with @GWASCatalog
⏰ Dec 11, 2025 | 12-1 PM ET
🔗ebispot.github.io/PEGASUS/
Wallace Wang retweeted
Our study, from @aklfahed @wallacemwang labs, shows that a multi-genomic (polygenic, monogenic, somatic) risk model improves incident atrial fibrillation risk prediction when added to a clinical risk score (CHARGE-AF) jamanetwork.com/journals/jam… @JAMACardio
Wallace Wang retweeted
🧵1/
Delighted to announce our new study: Machine learning-based penetrance of genetic variants by @IainSForrest et al. published in @ScienceMagazine!
Paper: science.org/doi/10.1126/scie…
Press release: mountsinai.org/about/newsroo…
@AIHealthMtSinai @SinaiGenetics
Wallace Wang retweeted
🚨 Big news from @SusztakLab! Our paper is out in @NatureGenet: "From Million-Cell Atlases to One-Patient Reports" 🧬🧑⚕️Together with biostats wizard @NancyRZhang and physician-scientist trainee @KonstantinKltz, we built a cross-species single-cell kidney atlas and analytics engine:
🔗 nature.com/articles/s41588-0…
Wallace Wang retweeted
Longdust, a new tool to identify highly repetitive STRs, VNTRs, satellite DNA and other low-complexity regions (LCRs). Similar to SDUST but for long regions.
github.com/lh3/longdust
Wallace Wang retweeted
Motivated by the favorable lipid indices and CV risk of ANGPLT3 & ANGPTL8 LoF carriers, @EliLillyandCo developed a combo ANGPTL3/8 mAb (LY3475766). Phase 1 RCT shows that LY3475766 recapitulates lipid patterns from human genetics nature.com/articles/s41591-0… @NatureMedicine @Giacomo_Ruotolo
HDL-C effects more reflective of ANGPTL8 LoF (high) than ANGPTL3 LoF (low).
Nice commentary from @ArchnaBajajMD & D. Rader nature.com/articles/s41591-0…
Wallace Wang retweeted
🚨 Excited to share our new manuscript in @circAHA led by @BellomoTiffany and team. We evaluated lipoprotein(a) as a prognostic marker for extracoronary atherosclerotic vascular disease progression in @uk_biobank.
👉 doi.org/10.1161/CIRCULATIONA…
🧵1/6
Wallace Wang retweeted
Two new papers in @NatureGenet from @patrick_ellinor and team
Expanding genetic discovery of rare, structural and common variation in atrial fibrillation
Sequencing >50K cases
nature.com/articles/s41588-0…
GWAS >180K cases
nature.com/articles/s41588-0…
Wallace Wang retweeted
NEW in @Circ_Gen led by @tigerstatdoc
Genomic and clinical risk factors of CAD display time-varying importance over the life course.
The importance of CAD PRS is highest earlier in life and diminishes with older age.
Collab with @pnatarajanmd
@MGHHeartHealth @mghcvrc @broadinstitute
ahajournals.org/doi/10.1161/…
Wallace Wang retweeted
NEW preprint led by @MinSeoKim_MD @Alisa_QiuliChen and Yang Sui
Metabolic Polygenic Risk Scores for Prediction of Obesity, Type 2 Diabetes, and Related Morbidities
O-MetPRS and D-MetPRS
🔹 Leverage 22 metabolic traits from over 10 million people
🔹Derived in UKB, validated in All of Us, MGB Biobank and KFSH&RC
🔹Outperform existing PRSs in 6 ancestry groups
🔹Predict numerous morbidities of diabesity
🔹Predict prescription of GLP1 receptor agonists even among people without obesity at baseline
Collaboration with @wallacemwang @patrick_ellinor
@broadinstitute @MGHHeartHealth @mghcvrc
Manuscript here
medrxiv.org/content/10.1101/…
X-planation from @MinSeoKim_MD below
I'm thrilled to share our latest preprint on metabolic polygenic risk score🧬!
We developed metabolic PRS using multi-ancestry GWAS of 22 metabolic traits from over 10 million people.
w/ @Alisa_QiuliChen, Yang Sui, @aklfahed @patrick_ellinor @pnatarajanmd, and more
Thread🧵
Wallace Wang retweeted
NEW from @MinSeoKim_MD and Xiong Yang
An Integrated Germline and Somatic Genomic Model Improves Risk Prediction for Coronary Artery Disease
medrxiv.org/content/10.1101/…
Awesome collaboration with @wallacemwang @pnatarajanmd and enabled by UKBB and TOPMed
@broadinstitute @MGHHeartHealth @mghcvrc
Thread below
Excited to share our preprint on the integrated genomic model for coronary artery disease (CAD)🧬!
We integrated 6 genetic drivers (PRS, FH, CHIP, LTL, ProPRS, MetPRS) to enhance risk prediction for CAD
From @broadinstitute @mghcvrc and Chinese Academy of Science
Thread🧵~
Wallace Wang retweeted
New in @JACCJournals #JACCimaging
Polygenic Risk Is Associated With Long-Term Coronary Plaque Progression and High-Risk Plaque
jacc.org/doi/10.1016/j.jcmg.…
/thread
Wallace Wang retweeted
Nice comparison of MR methods by Xianghong Hu published at AJHG @AJHGNews (sciencedirect.com/science/ar…) - which concludes that the best MR method out of 16 considered is... the method that their group developed!
Wallace Wang retweeted
10-year ASCVD risk prediction leads to older individuals being prioritized for statins missing opportunities for earlier risk recognition & prevention.
Our work led by @tigerstatdoc uses genetics & dynamic risk factor trajectories toward intersecting risk *early.* nature.com/articles/s41467-0… @NatureComms
Please share your cohorts discovery with us, I am honored to organize a special issue with @AniruddhPatelMD and @ZhaoDylan on large cohort study. GPB, a top 10 journal ranked in Bioinformatics and Computational biology.
Special Issue "New Era of Large Cohort Studies" organized by @AniruddhPatelMD @wallacemwang @ZhaoDylan --publish your large cohort studies in GPB! academic.oup.com/gpb/pages/c…
Wallace Wang retweeted
🔥 Hiring a funded postdoctoral fellow position in human genetics! Come join us @CGM_MGH @broadinstitute @harvardmed!
🔥 Apply: partners.taleo.net/careersec…
Wallace Wang retweeted
Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial Hypercholesterolemia
@RensReeskamp @injeong_shim @amitvkhera
sciencedirect.com/science/ar…
Wallace Wang retweeted
Terrific summary of our recent paper describing an enhanced polygenic score for coronary artery disease:
rdcu.be/dgAR3
Paper (open-access): nature.com/articles/s41591-0…
