@weiwsmiling

computational biologist. DNA damage and repair.

 Shanghai, China
wulab-cemcs.com/
Joined April 2017
  • Tweets265
  • Following240
  • Followers147
Excited to see this study finally out in Mol Cell, kwnsfk27.r.eu-west-1.awstrac…
Wei Wu@weiwsmiling8 Feb 2025
Delighted to share this beautiful story of collaboration with Lu's and ZZ's groups! Thank you for introducing me to the fascinating world of transposon elements.
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Why does cisplatin treatment cause neurons to die? We identify that too much DNA repair exhausts the low level of dNTPs in neurons and drives cisplatin neurotoxicity. From @nussenza lab. Thanks to our many great collaborators on this work! Check it out: cell.com/cell/fulltext/S0092…

DNA repair drives cisplatin-induced neuronal death

In neurons, cisplatin-induced DNA damage is repaired by NER, but low dNTP pools cause NER to promote death rather than survival. Deoxynucleoside supplementation or genetic upregulation of dNTP...

cell.com
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Tracking mobilization uncovers an evolutionarily conserved mechanism in suppressing mobile genetic elements dlvr.it/TT87w2
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Excited to share our new collaborative work with Lu Wang’s lab @LuWang_TE ! We uncover a de novo H3.2K9me2 deposition pathway that establishes heterochromatin to suppress transposon mobilization during fly somatic development. doi.org/10.1093/nar/gkag146
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Excellent opportunity in excellent lab.
Iva Tolić@ToliclabJan 28
PhD position in my lab!
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Wei Wu retweeted
Heng Li@lh3lh3Jan 14
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
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🚨New pre-print out!🚨 Exciting collaboration with the Meek and Schmidt labs at Michigan State University. We discovered that Ku inhibits aberrant splicing caused by intronic Alu repeats. biorxiv.org/content/10.1101/…

Ku limits aberrant mRNA splicing promoted by intronic antisense Alu elements

Alu elements are short repeats that occupy approximately 10% of the human genome [1][1],[2][2]. Saturation of primate genomes with Alu sequences occurred at the prosimian/new-world monkey evolution...

biorxiv.org
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Two fresh papers from WuLab! 📊 A benchmark of ploidy estimation tools for bulk & single-cell WGS. 🧬 With Dr. Haiqiang Dai’s team, we built a complementary and affordable TCR profiling assay.
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links to these papers:1 advanced.onlinelibrary.wiley… 2: advanced.onlinelibrary.wiley… Congrats to my students Yawei and Zilv, and to my wonderful collaborators Haiqiang and Rui from his lab!
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Ever noticed that #CRISPR editing results differ between cells? Awesome PhD student @MSchlapansky developed "scOUT-seq" to measure single cell transcriptomes + editing. 1.2 million cells, 74 cell types, living 🐭. Cell subtypes differ wildly from bulk! biorxiv.org/content/10.1101/…

Cell-stereotyped DNA repair outcomes are widespread during genome editing

Genome editing outcomes are governed by DNA repair pathways that vary with cell type and state. We developed scOUT-seq (single-cell Outcomes Using Transcript sequencing), a scalable approach that...

biorxiv.org
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New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. biorxiv.org/content/10.1101/…

Mitotic single-stranded DNA suppression by DDIAS

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet...

biorxiv.org
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Huge congrats Shuo!
Shuo Han@Shuo_Han_10 Sep 2025
Excited to share the first paper from my lab in @Nature ! We repurposed the widely used research tool, proximity labeling, to demonstrate its therapeutic potential in antigen amplification for immunotherapy using mouse tumor models and patient samples. nature.com/articles/s41586-0…

Amplifying antigen-induced cellular responses with proximity labelling

Nature - Red light- or ultrasound-controlled proximity labelling is engineered to stimulate clustering-induced receptor activation and downstream signalling amplification to promote antitumour...

nature.com
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JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. nature.com/naturecareers/job… Please repost!
Image of Toronto

ALT Image of Toronto

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Cytarabine has been the mainstay for AML treatment. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side effect: nature.com/articles/s41586-0…. Work led by Jia-Cheng Liu, Donpgeng Wang, Elsa Callen and many terrific collaborators!

Mechanism of cytarabine-induced neurotoxicity

Nature - Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas...

nature.com
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Happy to share our updated opinion on the physiological roles of BRCA1 in this new review: authors.elsevier.com/a/1lDKu…
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Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come nature.com/articles/s41586-0…

Ku limits RNA-induced innate immunity to allow Alu expansion in primates

Nature - Studies on the essentiality of Ku in human cells reveal that Ku interacts with diverse double-stranded RNA molecules, including antisense Alu, and enables tolerance of Alu sequence...

nature.com
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Our amazing group for #Recombination25! It’s been an fantastic few days of science, networking, and collaborations🥳 Lets celebrate in style at tonight’s gala dinner! 🎉💃
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Wei Wu retweeted
ASBMB@ASBMB14 Apr 2025
Happening Now in the Skyline Ballroom: Andre Nussenzweig is presenting his lecture, "Maintaining genome stability." asbmb.org/asbmb-today/people… #ASBMB25
Andre Nussenzweig delivers his award lecture on genome stability at the 2025 ASBMB Annual Meeting.

ALT Andre Nussenzweig delivers his award lecture on genome stability at the 2025 ASBMB Annual Meeting.

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We're incredibly excited to share our new method, Paired-Damage-seq, out @naturemethods today! This technique allows us to jointly analyze oxidative DNA damage and SSBs with RNA, all at the single-cell level (1/5). nature.com/articles/s41592-0…

Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability

Nature Methods - This work presents an in situ labeling-by-repair strategy, Paired-Damage-seq, to achieve joint profiling of oxidative and single-stranded DNA damage alongside gene expression in...

nature.com
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Learn how homology search might work in 3D genome! We combine very fast CRISPR and Hi C to look at 3D genome changes during DNA repair and found that break anchored DNA extrusion by cohesin can help search for homologous sequences.
Alberto Marin@AlbertoMarinG112 Feb 2025
1/n Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv! biorxiv.org/content/10.1101/…

Cohesin drives chromatin scanning during the RAD51-mediated homology search

Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce de novo formation of chromatin loops, with the break positioned at the loop...

biorxiv.org
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